4beta-Carboxy-19-nortotarol | CAS:55102-39-1

4beta-Carboxy-19-nortotarol

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Product Name	4beta-Carboxy-19-nortotarol
Price:
CAS No.:	55102-39-1
Catalog No.:	CFN96167
Molecular Formula:	C₂₀H₂₈O₃
Molecular Weight:	316.4 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The heartwoods of Podocarpus macrophyllus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not generation of superoxide anion.

Targets:

NADPH-oxidase

In vitro:

Planta Med., 1997, 63(3):213-5.

Antioxidative action of diterpenoids from Podocarpus nagi.[Pubmed: 9225601 ]

METHODS AND RESULTS:
Diterpenoids, totarol (1), totaradiol (2), 19-hydroxytotarol (3), totaral (4), 4beta-Carboxy-19-nortotarol (5), sugiol (6), isolated from Podocarpus nagi, were evaluated as antioxidants. Microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH were inhibited by these terpenoids. They inhibited linoleic acid autoxidation but not generation of superoxide anion. Totarol (1) protected mitochondrial respiratory enzyme activities against NADPH induced oxidative injury.
CONCLUSIONS:
Totarane diterpenes from P. nagi were shown to be effective to protect biological systems and function against various oxidative stresses.

4beta-Carboxy-19-nortotarol Description

Source:	The heartwoods of Podocarpus macrophyllus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Diterpenoids Compound Library NADPH-oxidase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1606 mL	15.8028 mL	31.6056 mL	63.2111 mL	79.0139 mL
5 mM	0.6321 mL	3.1606 mL	6.3211 mL	12.6422 mL	15.8028 mL
10 mM	0.3161 mL	1.5803 mL	3.1606 mL	6.3211 mL	7.9014 mL
50 mM	0.0632 mL	0.3161 mL	0.6321 mL	1.2642 mL	1.5803 mL
100 mM	0.0316 mL	0.158 mL	0.3161 mL	0.6321 mL	0.7901 mL

CFN97733	Totarol	511-15-9	286.46	C₂₀H₃₀O
CFN98610	Totaradiol	3772-56-3	302.5	C₂₀H₃₀O₂
CFN96167	4beta-Carboxy-19-nortotarol	55102-39-1	316.4	C₂₀H₂₈O₃
CFN96140	Nagilactone C	24338-53-2	362.4	C₁₉H₂₂O₇
CFN96150	Nagilactone B	19891-51-1	364.4	C₁₉H₂₄O₇
CFN89100	Hispidanin B	1616080-84-2	656.89	C₄₂H₅₆O₆