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    7-Amino-4-methylcoumarin
    7-Amino-4-methylcoumarin
    Information
    CAS No. 106562-32-7 Price
    Catalog No.CFN90420Purity>=98%
    Molecular Weight233.22Type of CompoundCoumarins
    FormulaC12H11NO4Physical DescriptionCryst.
    Download     COA    MSDSSimilar structuralComparison (Web)
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    7-Amino-4-methylcoumarin Description
    Source: The herbs of Guazuma ulmifolia
    Biological Activity or Inhibitors: 1. 7-Amino-4-methylcoumarin is more suitable as a substrate for enteropeptidase than GD(4)K-NA.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.2878 mL 21.439 mL 42.878 mL 85.7559 mL 107.1949 mL
    5 mM 0.8576 mL 4.2878 mL 8.5756 mL 17.1512 mL 21.439 mL
    10 mM 0.4288 mL 2.1439 mL 4.2878 mL 8.5756 mL 10.7195 mL
    50 mM 0.0858 mL 0.4288 mL 0.8576 mL 1.7151 mL 2.1439 mL
    100 mM 0.0429 mL 0.2144 mL 0.4288 mL 0.8576 mL 1.0719 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    7-Amino-4-methylcoumarin References Information
    Citation [1]

    BMB Rep. 2011 Jul;44(7):458-61.

    A fluorogenic method for measuring enteropeptidase activity: spectral shift in the emission of GD4K-conjugated 7-amino-4-methylcoumarin.[Pubmed: 21777516]
    We used shift in the emission spectrum of GD(4)K-conjugated 7-Amino-4-methylcoumarin (GD(4)K-AMC) as a fluorogenic method to measure enteropeptidase activity. The kinetic analysis revealed that enteropeptidase has a K(M) of 0.025 mM and a k(cat) of 65 sec(-1) for 7-Amino-4-methylcoumarin, whereas it has a K(M) of 0.5 to 0.6 mM and a k(cat) of 25 sec(-1) for GD(4)K-NA. The optimum pH of 7-Amino-4-methylcoumarin hydrolysis was pH 8.0. Our data indicate that 7-Amino-4-methylcoumarin is more suitable as a substrate for enteropeptidase than GD(4)K-NA.