Science | Nature | Cell | View More
Natural Products
Anwulignan
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Anwulignan
Price: $70 / 20mg
CAS No.: 107534-93-0
Catalog No.: CFN98539
Molecular Formula: C20H24O4
Molecular Weight: 328.41 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The fruits of Schisandra sphenanthera.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $18.0 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Ain Shams University (Egypt)
  • Subang Jaya Medical Centre (Malaysia)
  • Aveiro University (Portugal)
  • University of Madras (India)
  • The Institute of Cancer Research (United Kingdom)
  • Shanghai Institute of Organic C... (China)
  • Donald Danforth Plant Science C... (USA)
  • Calcutta University (India)
  • Indian Institute of Science (India)
  • Johannes Gutenberg University M... (Germany)
  • Molecular Biology Institute of ... (Spain)
  • More...
Package
Featured Products
Quercetin 3-O-neohesperidoside

Catalog No: CFN91148
CAS No: 32453-36-4
Price: $318/10mg
Daidzein

Catalog No: CFN98774
CAS No: 486-66-8
Price: $30/20mg
6beta-Hydroxystigmast-4-en-3-one

Catalog No: CFN98496
CAS No: 36450-02-9
Price: $ /
D-(+)-Glucose

Catalog No: CFN99769
CAS No: 50-99-7
Price: $30/20mg
Calycosin-7-O-beta-D-glucoside

Catalog No: CFN99141
CAS No: 20633-67-4
Price: $80/20mg
Chrysin

Catalog No: CFN98741
CAS No: 480-40-0
Price: $40/20mg
Calceolarioside B

Catalog No: CFN90647
CAS No: 105471-98-5
Price: $238/20mg
Obtusifolin

Catalog No: CFN90394
CAS No: 477-85-0
Price: $268/20mg
Deapi-platycodin D

Catalog No: CFN90472
CAS No: 78763-58-3
Price: $268/10mg
Elemicin

Catalog No: CFN90685
CAS No: 487-11-6
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Anwuligan has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities. (+)-Anwulignan has inhibitory effects on platelets aggregation induced by adenosine diphosphate (ADP) and platelet activating factor(PAF) in vitro.
Targets: PAFR | Antifection
In vitro:
Journal of Shanghai Medica, 2005, 32(4):467-70.
Effects of heteroclitin D, schisanhenol and ( + )-anwulignan on platelet aggregation.[Reference: WebLink]
To investigate the effects of three lignans: heteroclitin D (HD), schisanhenol (SAL) and ( + )-Anwulignan(AN) with different skeletons from Schisandraceae medicinal plants on platelet aggregation.
METHODS AND RESULTS:
At concentrations 0.05-25 mg/L of the three lignans, rabbit platelet aggregation induced by adenosine diphosphate (ADP) and platelet activating factor(PAF) were studied by Born's turbidimetry, the maximum time of platelet aggregation and platelet aggregation at 1,3,5 min were also observed. 1 HD and SAL inhibited the ADP- and PAF-induced platelet aggregation in a concentration-dependant manner. The inhibitory effect of AN was weak. 2 ADP-induced platelet aggregation at 1, 3,5 min were inhibited by HD and SAL in a similar manner. At 5 mg/L,AN inhibited platelet aggregation at 3 and 5 min significantly;The PAF-induced platelet aggregation at 1,3,5 min, the inhibition of HD at 1,3 min and of SAL at 3,5 min were more potent. 3 HD, SAL and AN had no effects on maximum time of ADP- and PAF-induced platelet aggregation.
CONCLUSIONS:
HD,SAL and AN have inhibitory effects on platelets aggregation induced by ADP and PAF in vitro. The inhibitory effect of HD is the most potent and could be one of the important active components from Kadsura medicinal plants.
In vivo:
Chin Med . 2011 Mar 4;6:10.
Effects of a multi-herbal extract on type 2 diabetes[Pubmed: 21375727]
Abstract Background: An aqueous extract of multi-hypoglycemic herbs of Panax ginseng C.A.Meyer, Pueraria lobata, Dioscorea batatas Decaisne, Rehmannia glutinosa, Amomum cadamomum Linné, Poncirus fructus and Evodia officinalis was investigated for its anti-diabetic effects in cell and animal models. Methods: Activities of PPARγ agonist, anti-inflammation, AMPK activator and anti-ER stress were measured in cell models and in db/db mice (a genetic animal model for type 2 diabetes). Results: While the extract stimulated PPARγ-dependent luciferase activity and activated AMPK in C2C12 cells, it inhibited TNF-α-stimulated IKKβ/NFkB signaling and attenuated ER stress in HepG2 cells. The db/db mice treated with the extract showed reduced fasting blood glucose and HbA1c levels, improved postprandial glucose levels, enhanced insulin sensitivity and significantly decreased plasma free fatty acid, triglyceride and total cholesterol. Conclusion: The aqueous extract of these seven hypoglycemic herbs demonstrated many therapeutic effects for the treatment of type 2 diabetes in cell and animal models.
Anwulignan Description
Source: The fruits of Schisandra sphenanthera.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Verbasoside

Catalog No: CFN95015
CAS No: 61548-34-3
Price: $318/5mg
Quasipanaxatriol

Catalog No: CFN95248
CAS No: 171903-78-9
Price: $413/5mg
12-Acetoxy ganoderic acid D

Catalog No: CFN95535
CAS No: N/A
Price: $318/5mg
Silychristin B

Catalog No: CFN95160
CAS No: 879325-58-3
Price: $318/5mg
Tembetarine

Catalog No: CFN95542
CAS No: 18446-73-6
Price: $318/5mg
New compound 16

Catalog No: CFN95465
CAS No: N/A
Price: $413/5mg
Mahuannin B

Catalog No: CFN95554
CAS No: 82796-37-0
Price: $318/5mg
Lathyranoic acid A

Catalog No: CFN95325
CAS No: 850560-44-0
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.045 mL 15.2249 mL 30.4497 mL 60.8995 mL 76.1244 mL
5 mM 0.609 mL 3.045 mL 6.0899 mL 12.1799 mL 15.2249 mL
10 mM 0.3045 mL 1.5225 mL 3.045 mL 6.0899 mL 7.6124 mL
50 mM 0.0609 mL 0.3045 mL 0.609 mL 1.218 mL 1.5225 mL
100 mM 0.0304 mL 0.1522 mL 0.3045 mL 0.609 mL 0.7612 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Se Pu. 2009 May;27(3):313-7.
Selection of mobile phases for the determination of gamma-schisandrin and multi-active constituents in Schisandra chinensis and its preparations by high performance liquid chromatography.[Pubmed: 19803136]

METHODS AND RESULTS:
The systems of mobile phase for the determination of gamma-schisandrin in Schisandra chinensis and its preparations were developed by high performance liquid chromatography (HPLC). The separation was performed on a Shim-pack VP-ODS column (250 mm x 4.6 mm, 5 microm) at 30 degrees C, the detection wavelength was set at 285 nm and the flow rate was 1.0 mL/min. Retention times and separation were investigated in mixed solution of three reference substances (gamma-schisandrin, Anwulignan, and deoxyschizandrin) and methanol extract of Schisandra chinensis by different systems and proportions of mobile phases to select optimal conditions for the determination of gamma-schisandrin. The results showed that the complete separation of gamma-schisandrin and Anwulignan was difficult in the systems of methanol-water and methanol-acetic acid-water. The separation of gamma-schisandrin, Anwulignan and deoxyschizandrin can be completed in the systems of acetonitrile-methanol-water and acetonitrile-acetic acid-water when their proportions were suitable. The mobile phase of acetonitrile-methanol-water (17:58:25, v/v/v) was selected for the determination of deoxyschizandrin, gamma-schisandrin and Anwulignan in Schisandra chinensis and Hugan tablets.
CONCLUSIONS:
The determination results of the three substances were satisfactory with the relative standard deviations (n = 4) ranged from 0.95% to 5.8%, and the average recoveries ranged from 94.50% to 105.6%. The efficiency of separation and the results of determination were satisfactory for the real samples.
Quercetin 3-O-neohesperidoside

Catalog No: CFN91148
CAS No: 32453-36-4
Price: $318/10mg
Daidzein

Catalog No: CFN98774
CAS No: 486-66-8
Price: $30/20mg
6beta-Hydroxystigmast-4-en-3-one

Catalog No: CFN98496
CAS No: 36450-02-9
Price: $ /
D-(+)-Glucose

Catalog No: CFN99769
CAS No: 50-99-7
Price: $30/20mg
Calycosin-7-O-beta-D-glucoside

Catalog No: CFN99141
CAS No: 20633-67-4
Price: $80/20mg
Chrysin

Catalog No: CFN98741
CAS No: 480-40-0
Price: $40/20mg
Calceolarioside B

Catalog No: CFN90647
CAS No: 105471-98-5
Price: $238/20mg
Obtusifolin

Catalog No: CFN90394
CAS No: 477-85-0
Price: $268/20mg
Deapi-platycodin D

Catalog No: CFN90472
CAS No: 78763-58-3
Price: $268/10mg
Elemicin

Catalog No: CFN90685
CAS No: 487-11-6
Price: $30/20mg
Tags: buy Anwulignan | Anwulignan supplier | purchase Anwulignan | Anwulignan cost | Anwulignan manufacturer | order Anwulignan | Anwulignan distributor