ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Phytomedicine.2015, 22(4):498-503Appl Microbiol Biotechnol....2016...Mediators Inflamm.2016, 2016:7216912J Basic Clin Physiol Pharmacol....2016...Srinagarind Medical Journal2017, 32(1)Korean j.of Pharm.2017, 70-76PLoS One.2018, 13(3):e0193386The Pharmaceutical Society of Jap...2018...
Evid Based Complement Alternat Me...2018...J Cell Mol Med.2018, 22(9):4236-4242Korean J of Medicinal Crop Scienc...2018...Molecules.2018, 23(12):E3103Molecules.2018, 23(9):E2121Phytomedicine.2018, 41:62-66J Nat Med.2018, 72(3):734-744Saf Health Work.2019, 10(2):196-204
Chem Biol Interact.2019, 298:1-7J Enzyme Inhib Med Chem....2019...Korean J of Crop Science2019, 452-458Comput Biol Chem.2019, 83:107096Front Plant Sci.2020, 10:1705Int J Pharmacol2020, 16:1-9J Ethnopharmacol.2020, 249:112381
Our products had been exported to the following research institutions and universities, And still growing.
Korea Institute of Oriental Med... (Korea)VIT University (India)Copenhagen University (Denmark)Universidade Federal de Santa C... (Brazil)
Guangzhou Institutes of Biomedi... (China)Colorado State University (USA)VIB Department of Plant Systems... (Belgium)Julius Kühn-Institut (Germany)
University of Pretoria (South Africa)University of Hertfordshire (United Kingdom)Kazusa DNA Research Institute (Japan)
Related Screening Libraries
||Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway, and can be further developed as a promising drug for the treatment of inflammation-related diseases such as atherosclerosis.|
||TNF-α | p38 MAPK | ERK | JAK | STAT|
|China Natural Drugs (English Version), 2019. |
|Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway.[Reference: WebLink]|
|Macrophages play an important role in inflammation, and excessive and chronic activation of macrophages leads to systemic inflammatory diseases, such as atherosclerosis and rheumatoid arthritis.|
METHODS AND RESULTS:
In this paper, we explored the anti-inflammatory effect of Broussonin E, a novel phenolic compound isolated from the barks of Broussonetia kanzinoki, and its underlying molecular mechanisms. We discovered that Broussonin E could suppress the LPS-induced pro-inflammatory production in RAW264.7 cells, involving TNF-α, IL-1β, IL-6, COX-2 and iNOS. And Broussonin E enhanced the expressions of anti-inflammatory mediators such as IL-10, CD206 and arginase-1(Arg-1) in LPS-stimulated RAW264.7 cells. Further, we demonstrated that Broussonin E inhibited the LPS-stimulated phosphorylation of ERK and p38 MAPK. Moreover, we found that Broussonin E could activate janus kinase(JAK) 2, signal transducer and activator of transcription(STAT) 3. Downregulated pro-inflammatory cytokines and upregulated anti-inflammatory factors by Broussonin E were abolished by using the inhibitor of JAK2-STAT3 pathway, WP1066.
Taken together, our results showed that Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway, and can be further developed as a promising drug for the treatment of inflammation-related diseases such as atherosclerosis.
Broussonin E Description
||The branches of Broussonetia papyrifera.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.