• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Crocin II
    Information
    CAS No. 55750-84-0 Price $188 / 20mg
    Catalog No.CFN99928Purity>=98%
    Molecular Weight814.83Type of CompoundDiterpenoids
    FormulaC38H54O19Physical DescriptionDark red powder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • Melbourne University (Australia)
  • Sapienza University of Rome (Italy)
  • Instytut Nawozów Sztucznych w P... (Poland)
  • Charles University in Prague (Czech Republic)
  • National Cancer Center Research ... (Japan)
  • Kyushu University (Japan)
  • Chiang Mai University (Thailand)
  • The Institute of Cancer Research (United Kingdom)
  • Agricultural Research Organizati... (Israel)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Pretoria (South Africa)
  • More...
  • Package
    Featured Products
    Viscidulin III

    Catalog No: CFN97488
    CAS No: 92519-91-0
    Price: $413/5mg
    Chamaejasmine

    Catalog No: CFN92154
    CAS No: 69618-96-8
    Price: $463/5mg
    meso-Hannokinol

    Catalog No: CFN90864
    CAS No: N/A
    Price: $368/5mg
    Kaempferol 3-O-arabinoside

    Catalog No: CFN97572
    CAS No: 99882-10-7
    Price: $398/5mg
    Salviolone

    Catalog No: CFN92163
    CAS No: 119400-86-1
    Price: $595/5mg
    Biological Activity
    Description: Crocin has antihyperlipidemic, antidepressant , anti-inflammatory and anti-apoptotic effects. It can reduce the protein expression of iNOS and caspase-3, and increase CREB, BDNF and VGF levels in hippocampus.
    Targets: NOS | Caspase
    In vivo:
    Braz.J.Pharm.Sci., 2015, 51(3):637-642
    A preliminary study of the anti-inflammatory and anti-apoptotic effects of crocin against gastric ischemia-reperfusion injury in rats[Reference: WebLink]
    The aim of the present study was to investigate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rats.
    METHODS AND RESULTS:
    Thirty-two male rats were randomly divided into sham, I/R, I/R + crocin pretreatment and crocin alone groups. To induce I/R lesions, the celiac artery was clamped for 30 min, and the clamp was then removed to allow reperfusion for 3 h. Crocin-pretreated rats received crocin (15 mg/kg, i.p.) 30 min prior to the induction of I/R injury. Samples of gastric mucosa were collected to quantify the protein expression of caspase-3, an apoptotic factor, and inducible nitric oxide synthase (iNOS), a pro-inflammatory protein, by Western blot. Pretreatment with crocin decreased the total area of gastric lesions and decreased the protein expression levels of caspase-3 and iNOS induced by I/R injury.
    CONCLUSIONS:
    Our findings showed a protective effect of crocin in gastric mucosa against I/R injury. This effect of crocin was mainly mediated by reducing the protein expression of iNOS and caspase-3.
    Crocin II Description
    Source: The stigma of Crocus sativus L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Dihydrowithaferin A

    Catalog No: CFN91055
    CAS No: 5589-41-3
    Price: $258/5mg
    1,4-Dihydroxy-2-carbomethoxy-3-pre...

    Catalog No: CFN95100
    CAS No: 1415729-43-9
    Price: $318/5mg
    Arjunic acid

    Catalog No: CFN98397
    CAS No: 31298-06-3
    Price: $413/5mg
    Nodakenetin

    Catalog No: CFN98788
    CAS No: 495-32-9
    Price: $268/10mg
    Decursitin D

    Catalog No: CFN95002
    CAS No: 245446-61-1
    Price: $388/5mg
    Glycyrrhisoflavone

    Catalog No: CFN90817
    CAS No: 116709-70-7
    Price: $368/10mg
    Methylnissolin-3-O-glucoside

    Catalog No: CFN93199
    CAS No: 94367-42-7
    Price: $218/20mg
    8-Prenylnaringenin

    Catalog No: CFN92016
    CAS No: 53846-50-7
    Price: $298/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2272 mL 6.1362 mL 12.2725 mL 24.545 mL 30.6812 mL
    5 mM 0.2454 mL 1.2272 mL 2.4545 mL 4.909 mL 6.1362 mL
    10 mM 0.1227 mL 0.6136 mL 1.2272 mL 2.4545 mL 3.0681 mL
    50 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.4909 mL 0.6136 mL
    100 mM 0.0123 mL 0.0614 mL 0.1227 mL 0.2454 mL 0.3068 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Biol Pharm Bull. 2005 Nov;28(11):2106-10.
    Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin.[Pubmed: 16272698]
    The pancreatic lipase inhibitors were isolated from the fructus of Gardenia jasminoides ELLIS, and their antihyperlipidemic activities were measured. Gardeniae fructus (GF) water extract inhibited pancreatic lipase activity.
    METHODS AND RESULTS:
    Crocetin and crocin were isolated from GF water extract as inhibitors of pancreatic lipase with an IC50 value of 2.1 and 2.6 mg/ml (triolein as a substrate). Crocin and crocetin significantly inhibited the increase of serum TG level in corn oil feeding-induced triglyceridemic mice, as well as that of serum triglyceride and total and LDL cholesterol levels in Triton WR-1339-induced hyperlipidemic mice. These compounds also showed hypolipidemic activity in hyperlipidemic mice induced by high cholesterol, high fat or high carbohydrate diets for 5 weeks.
    CONCLUSIONS:
    The results suggest that the hypolipidemic activity of GF and its component crocin may be due to the inhibition of pancreatic lipase and crocin, and its metabolite, crocetin, can improve hyperlipidemia.