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    Dictamnine
    Information
    CAS No. 484-29-7 Price $178 / 20mg
    Catalog No.CFN99783Purity>=98%
    Molecular Weight199.21Type of CompoundAlkaloids
    FormulaC12H9NO2Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Dictamnine Description
    Source: The root barks of Dictamnus dasycarpus Turcz.
    Biological Activity or Inhibitors: 1. Dictamnine,a natural plant product, has anti-microbial activity against bacteria and fungi.
    2. Dictamnine induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration ,in which mitochondria and caspase were not involved.
    3. Dictamnine was enhanced by DHA, induced A549 cell apoptosis via a caspase-dependent pathway .
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.0198 mL 25.0991 mL 50.1983 mL 100.3966 mL 125.4957 mL
    5 mM 1.004 mL 5.0198 mL 10.0397 mL 20.0793 mL 25.0991 mL
    10 mM 0.502 mL 2.5099 mL 5.0198 mL 10.0397 mL 12.5496 mL
    50 mM 0.1004 mL 0.502 mL 1.004 mL 2.0079 mL 2.5099 mL
    100 mM 0.0502 mL 0.251 mL 0.502 mL 1.004 mL 1.255 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Dictamnine References Information
    Citation [1]

    Asian Pac J Cancer Prev. 2013;14(10):5895-900.

    Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells.[Pubmed: 24289596]
    Dictamnine (Dic) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells and dihydroartemisinin (DHA) also has potent anticancer activity on various tumour cell lines. This report explores the molecular mechanisms by which Dictamnine treatment and combination treatment with DHA and Dictamnine cause apoptosis in human lung adenocarcinoma A549 cells. Dictamnine treatment induced concentration- and time-dependent cell death. FCM analysis showed that Dictamnine induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dictamnine-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis. Combination treatment with DHA and Dictamnine dramatically increased the apoptotic cell death compared to Dic alone. Interestingly, pretreatment with z-DQMD-fmk significantly attenuated DHA and Dictamnine co-induced apoptosis, implying that caspase-3 plays an important role in Dictamnine and DHA co-induced cell apoptosis. Collectively, we found that Dictamnine induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which mitochondria and caspase were not involved and DHA enhanced Dictamnine induced A549 cell apoptosis via a caspase-dependent pathway.
    Citation [2]

    J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Dec 30;942-943:1-8.

    Pharmacokinetics, tissue distribution and excretion study of dictamnine, a major bioactive component from the root bark of Dictamnus dasycarpus Turcz. (Rutaceae).[Pubmed: 24200865]
    Dictamnine is an herbal ingredient isolated from the root bark of Dictamnus dasycarpus Turcz. (Rutaceae). The present study was aimed at the development of an ultra-high performance liquid chromatography-tandem mass spectrometry method to quantify the concentration of Dictamnine in rat plasma and tissues for the in vivo pharmacokinetics, tissue distribution and excretion study. Biological samples were processed with protein precipitation. Skimmianine was chosen as internal standard. The chromatographic separation was carried out on a Thermo Syncronis C18 column (2.1mm×50mm, 1.7μm) with an isocratic mobile phase consisting of methanol and 0.1% formic acid water (75:25, v/v). The detection was accomplished by using positive ion electrospray ionization in multiple reaction monitoring (MRM) mode. The MS/MS ion transitions were monitored at m/z 200.0→129.0 for Dictamnine and 260.3→227.1 for IS, respectively. An excellent linearity was observed over the concentration range from 0.5 to 250ng/mL. The lower limit of quantification (LLOQ) was 0.5ng/mL for Dictamnine. The developed method was rapid, accurate, and highly sensitive and selective. It was successfully applied to the in vivo pharmacokinetics, tissue distribution and excretion study of Dictamnine in rats after oral or intravenous administration of Dictamnine.
    Citation [3]

    J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jun 1;928:44-51.

    Simultaneous determination of limonin, dictamnine, obacunone and fraxinellone in rat plasma by a validated UHPLC-MS/MS and its application to a pharmacokinetic study after oral administration of Cortex Dictamni extract.[Pubmed: 23611843]
    A rapid and selective ultra high performance liquid chromatography-tandem mass spectrometry method was developed for the simultaneous determination of four major ingredients in Cortex Dictamni extract, including limonin, Dictamnine, obacunone and fraxinellone in rats plasma. Nimodipine was used as the internal standard. Following extraction by methyl tert-butyl ether, the analytes were separated on a Thermo Syncronis C18 column by a gradient elution within a runtime of 9min. The mobile phase consisted of A (methanol) and B (2mmol/L ammonium acetate in water). The detection was accomplished by using positive ion electrospray ionization in multiple reaction monitoring mode. The method was linear for all analytes over investigated range with all correlation coefficients greater than 0.998. The lower limits of quantification were 9.18ng/mL for limonin, 12.0ng/mL for Dictamnine, 16.05ng/mL for obacunone and 4.59ng/mL for fraxinellone. The intra- and inter-day precision (RSD%) was within 10% and the accuracy (RE%) ranged from -12.9% to 9.7%. This rapid and sensitive method was fully validated and successfully applied to the pharmacokinetic study of limonin, Dictamnine, obacunone and fraxinellone in the rat plasma after oral administration of Cortex Dictamni extract.
    Citation [4]

    Yeast. 2008 Sep;25(9):631-41.

    Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine.[Pubmed: 18727144]
    Dictamnine, a natural plant product, has been reported to have antimicrobial activity against bacteria and fungi; however, the Dictamnine response mechanisms of microorganisms are still poorly understood. We have shown that Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml. Commercial oligonucleotide microarrays were used to determine the global transcriptional response of S. cerevisiae triggered by treatment with Dictamnine. We interpreted our microarray data using the hierarchical clustering tool, T-profiler. Several major transcriptional responses were induced by Dictamnine. The first was the induced environmental stress response, mainly under the control of the Msn2p and Msn4p transcription factors, and the repressed environmental stress response in genes containing the PAC (RNA polymerase A and C box) and rRPE (ribosomal RNA processing element) motifs. The second was the Upc2p-mediated response involved in lipid biosynthesis. The third comprised the PDR3- and RPN4-mediated responses involved in multidrug resistance (MDR). Finally, the TBP-mediated response was induced with Dictamnine treatment. TBP is an essential general transcription factor involved in directing the transcription of genes. Quantitative real-time RT-PCR was performed on selected genes to verify the microarray results. Furthermore, morphological transitions during Dictamnine exposure to S. cerevisiae L1190 (MATa/alpha) were examined, using confocal laser microscopy.