ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
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More articles cited ChemFaces products.
Auburn, Alabama2015 Aug 1Faculty of Chem. & Nat. Resource Eng.Jul. 2014Mol. & Cell. ToxicologySep. 2017;J Bone Miner Res. 2017 Jul 26.J Drug Target.2016 Feb 24:1-28.
Anal Bioanal Chem.2018 Feb;J Nat Prod. 2017 Apr 28;Int J Mol Sci. 2017 May 11;Free Radic Biol Med.2016 Jun 25;97:307-319. US20170000760 A1Jan 5, 2017
Biochem Pharmacol. 2017 Apr 15;Advance Publication2015 Aug 18Tropical J. of Pha. ResearchNo 3 (2017) Food Chem. 2017 Apr 15;
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||Ethyl vanillate is a strong hydrogen peroxide scavenger, it may serve as an adjunct therapy for the treatment of vitiligo, although changes in pigmentation are mild clinically. Ethyl vanillate may be useful in selected cases of disseminated coccidioidomycosis.|
|Calif Med. 1954 May;80(5):349-56. |
|Disseminated coccidioidomycosis; treatment with ethyl vanillate; a preliminary report.[Pubmed: 13150209]|
METHODS AND RESULTS:
Ethyl vanillate, previously reported to be useful in the treatment of disseminated histoplasmosis, was administered to eight patients with disseminated coccidioidomycosis.
Therapeutically effective concentrations of Ethyl vanillate were obtained in only three patients, but, in them, the disease was apparently arrested. Failures occurred with patients who were too ill to tolerate the large amounts of Ethyl vanillate required to attain a therapeutic concentration in the blood. The principal difficulties of administering Ethyl vanillate are (a) the large doses required and (b) the lack of a parenterally administrable form of the drug.
Ethyl vanillate, although not universally applicable, may be useful in selected cases of disseminated coccidioidomycosis and should be given further trial.
|Iran J Med Sci. 2015 Nov; 40(6): 478–484. |
|Evaluation of the Efficacy of Topical Ethyl Vanillate in Enhancing the Effect of Narrow Band Ultraviolet B against Vitiligo: A Double Blind Randomized, Placebo-Controlled Clinical Trial.[Pubmed: 26538775]|
Vitiligo is an acquired disease of skin that presents with depigmented patches due to lack of melanocytes in the epidermis. Accumulation of toxic free radicals like hydrogen peroxide in the epidermis may be responsible for melanocytes death. Since Ethyl vanillate (vanillic acid ethyl ester) is a strong hydrogen peroxide scavenger, it may be effective against vitiligo. This study was carried out to evaluate the effect of Ethyl vanillate cream on vitiligo patients receiving phototherapy.
METHODS AND RESULTS:
A double-blind placebo-controlled clinical trial using Ethyl vanillate cream 20% was performed on 30 cases of generalized stable vitiligo (randomly selected) who were receiving phototherapy in the outpatient clinic of Faghihi Hospital (Shiraz, Iran). The patients randomly applied Ethyl vanillate on an assigned lesion (left or right side of the body) and placebo on the opposite side lesion (almost the same size and location) twice a day for 3 months, while receiving a narrow band ultraviolet B (NB-UVB) 2-3 times weekly. Photos were taken at the beginning of the trial and at the end of 4(th), 8(th), and 12(th) weeks. Then, images were compared with the photos from the beginning of the trial based on VASI score.
There was a significant change in pigmentation after applying Ethyl vanillate compared with baseline in medication side (P=0.002), but no significant change in placebo side (P=0.066). Additionally, there was a significant difference between medication and placebo sides in pigmentation (P=0.005).
Ethyl vanillate may serve as an adjunct therapy for the treatment of vitiligo, although changes in pigmentation are mild clinically.
Ethyl vanillate Description
||The herbs of Cymbopogon javanensis
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.