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    Isoacteoside
    Information
    CAS No. 61303-13-7 Price $178 / 20mg
    Catalog No.CFN97049Purity>=98%
    Molecular Weight624.6 Type of CompoundPhenylpropanoids
    FormulaC29H36O15Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Isoacteoside Description
    Source: The herb of Pedicularis striata Pall.
    Biological Activity or Inhibitors: 1. Isoacteoside possesses antioxidant property.
    2. Isoacteoside has anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular signal-regulated protein kinase) and nuclear factor-kappa B pathways.
    Solvent: Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.601 mL 8.0051 mL 16.0102 mL 32.0205 mL 40.0256 mL
    5 mM 0.3202 mL 1.601 mL 3.202 mL 6.4041 mL 8.0051 mL
    10 mM 0.1601 mL 0.8005 mL 1.601 mL 3.202 mL 4.0026 mL
    50 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
    100 mM 0.016 mL 0.0801 mL 0.1601 mL 0.3202 mL 0.4003 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Isoacteoside References Information
    Citation [1]

    Immunopharmacol Immunotoxicol. 2015 May 15:1-7.

    Anti-inflammatory effects of isoacteoside from Abeliophyllum distichum.[Pubmed: 25975581]
    Isoacteoside, a dihydroxypheynylethyl glycoside, is a major bioactive component of Abeliophyllum distichum (White Forsythia) which is a deciduous shrub native to the south and central areas of Korea. The present study is designed to evaluate the anti-inflammatory activities and underlying mechanisms of Isoacteoside in human mast cell line, HMC-1 cells. We isolated Isoacteoside from A. distichum. The anti-inflammatory effect of Isoacteoside was investigated in HMC-1 cells by studying the following markers: phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor alpha (TNF-α) secretion and mRNA expression by ELISA and RT-PCR, respectively. In addition, mechanism related to anti-inflammatory was investigated by Western blotting. Isoacteoside significantly suppressed the production and mRNA expression of proinflammatory cytokines including IL-1β, IL-6, IL-8 and TNF-α in PMACI-stimulated HMC-1 cells without cytotoxicity. It was found that anti-inflammatory effects of Isoacteoside are mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular signal-regulated protein kinase) and nuclear factor-kappa B pathways. Taken together, the present findings provide new insights that Isoacteoside may be a promising anti-inflammatory agent for inflammatory disorders.
    Citation [2]

    J Toxicol Environ Health A. 2005 Mar 12;68(5):389-400.

    Antioxidant activity of isoacteoside from Clerodendron trichotomum.[Pubmed: 15799629]
    The antioxidant properties of Isoacteoside, isolated from Clerodendron trichotomum (Verbenaceae), were investigated. This compound scavenged intracellular reactive oxygen species (ROS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and prevented lipid peroxidation. This radical scavenging activity of Isoacteoside protected cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O2). Furthermore, Isoacteoside reduced the apoptotic cells formation induced by H2O2, as demonstrated by the decreased number of sub-G1 hypo-diploid cells and apoptotic cell body formation. However, Isoacteoside increased the activities of cellular antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Taken together, these findings suggest that Isoacteoside, isolated from C. trichotomum, possesses antioxidant properties.