|Description:||1. Isochlorogenic acid A has antiviral activity.|
2. Isochlorogenic acid A has antioxidant activity.
3. Isochlorogenic acid A has hepatoprotective and potent anti-hepatitis B activities.
|Targets:||HBV | HO-1|
|Source:||The flowerbud of Lonicera japonica Thunb.|
|Solvent:||DMSO, Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||1.9363 mL||9.6815 mL||19.363 mL||38.7259 mL||48.4074 mL|
|5 mM||0.3873 mL||1.9363 mL||3.8726 mL||7.7452 mL||9.6815 mL|
|10 mM||0.1936 mL||0.9681 mL||1.9363 mL||3.8726 mL||4.8407 mL|
|50 mM||0.0387 mL||0.1936 mL||0.3873 mL||0.7745 mL||0.9681 mL|
|100 mM||0.0194 mL||0.0968 mL||0.1936 mL||0.3873 mL||0.4841 mL|
J Ethnopharmacol. 2012 Oct 31;144(1):190-4.
|Hepatoprotective and antiviral properties of isochlorogenic acid A from Laggera alata against hepatitis B virus infection.[Pubmed: 22982394]|
|Isochlorogenic acid A was verified to possess the potent anti-hepatitis B activity. The anti-HBV target of Isochlorogenic acid A is probably associated with blocking the translation step of the HBV replication. Overexpression of HO-1 may contribute to the anti-HBV activity of Isochlorogenic acid A by reducing the stability of the HBV core protein and thus blocking the refill of nuclear HBV cccDNA. Additionally, the hepatoprotective effect of Isochlorogenic acid A could be achieved by its antioxidative property and induction of HO-1.|
PLoS One. 2014 Sep 2;9(9):e106254.
|The activity-integrated method for quality assessment of reduning injection by on-line DPPH-CE-DAD.[Pubmed: 25181475]|
|A sensitive on-line DPPH-CE-DAD method was developed and validated for both screening and determining the concentration of seven antioxidants of Reduning injection. The pH and concentrations of buffer solution, SDS, β-CD and organic modifier were studied for the detection of DPPH and seven antioxidants. By on-line mixing DPPH and sample solution, a DPPH-CE method for testing the antioxidant activity of the complex matrix was successfully established and used to screen the antioxidant components of Reduning injection. Then, antioxidant components including caffeic acid, Isochlorogenic acid A, isochlorogenic acid B, isochlorogenic acid C, chlorogenic acid, neochlorogenic acid and cryptochlorogenic acid were quantified by the newly established CE-DAD method.|