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    Maltotetraose
    Maltotetraose
    Information
    CAS No. 34612-38-9 Price $218 / 20mg
    Catalog No.CFN90871Purity>=98%
    Molecular Weight666.6Type of CompoundMiscellaneous
    FormulaC24H42O21Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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    Maltotetraose Description
    Source: From brewpub beer carbohydrates.
    Biological Activity or Inhibitors: 1. Maltotetraose and stachyose are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression of early atherosclerosis development and could be developed as a dietary supplement for cardiovascular health.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5002 mL 7.5008 mL 15.0015 mL 30.003 mL 37.5038 mL
    5 mM 0.3 mL 1.5002 mL 3.0003 mL 6.0006 mL 7.5008 mL
    10 mM 0.15 mL 0.7501 mL 1.5002 mL 3.0003 mL 3.7504 mL
    50 mM 0.03 mL 0.15 mL 0.3 mL 0.6001 mL 0.7501 mL
    100 mM 0.015 mL 0.075 mL 0.15 mL 0.3 mL 0.375 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Maltotetraose References Information
    Citation [1]

    Mol Nutr Food Res. 2016 Sep;60(9):2086-97.

    Inhibition of PDGF-induced migration and TNF-α-induced ICAM-1 expression by maltotetraose from bamboo stem extract (BSE) in mouse vascular smooth muscle cells.[Pubmed: 27067145]
    Expression of intercellular adhesion molecule-1 (ICAM-1) on vascular smooth muscle cells (VSMCs) plays an important role in the progression of atherosclerosis. We investigated the effects of bamboo stem extract (BSE) on motility and ICAM-1 expression by using mouse MOVAS-1 cells. Active constituents of BSE exhibiting an inhibitory activity on TNF-α-induced ICAM1 expression were identified using HPLC.METHODS AND RESULTS: The effects of BSE on platelet-derived growth factor (PDGF)-BB-induced migration, tumor necrosis factor alpha (TNF-α)-induced expression of ICAM-1, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation were investigated. BSE inhibited migration of MOVAS-1 cells and sprout formation by mouse aorta explants. Reverse transcription PCR analysis and promoter reporter assays revealed that BSE suppressed ICAM-1 expression by inhibiting NF-κB activity. In addition, BSE reduced adhesion between VSMCs and monocytes. Several oligosaccharides were identified in BSE. Among the oligosaccharides contained in BSE, Maltotetraose and stachyose were potent inhibitors of TNF-α-induced ICAM-1 expression. We confirmed that Maltotetraose reduced PDGF-induced sprout formation by mouse aorta explants and inhibited TNF-α-induced NF-κB activation and ICAM-1 expression in MOVAS-1 cells. CONCLUSION: The BSE constituent Maltotetraose may be beneficial in the suppression of early atherosclerosis development and could be developed as a dietary supplement for cardiovascular health.
    Citation [2]

    FEBS J. 2005 May;272(10):2416-27.

    Oligosaccharide synthesis in Fibrobacter succinogenes S85 and its modulation by the substrate.[Pubmed: 15885092 ]
    The hydrolytic properties of the isoenzymes of human pancreatic and salivary α-amylase (1,4-glucan 4-glucanohydrolase, EC 3.2.1.1) were studied. The eight pancreatic isoenzymes split glycogen and starch into glucose, maltose, maltotriose, Maltotetraose and oligosaccharides of 5–10 glucose units. Maltotetraose is further digested to lower homologues. The percentage of conversion to these products is dependent on the substrate and varies from one isoenzyme to another. The six salivary isoenzymes split glycogen and starch into maltose, maltotriose, Maltotetraose, pannose and oligosaccharides of 5–10 glucose units. Maltotetraose and pannose are further digested to lower homologues. The percentage of conversion to these products is dependent on the substrate and is specific for each isoenzyme.
    Citation [3]

    Food Chem. 2014 Jan 1;142:152-8.

    Characterisation of brewpub beer carbohydrates using high performance anion exchange chromatography coupled with pulsed amperometric detection.[Pubmed: 24001825 ]
    High performance anion exchange chromatography (HPAEC) coupled with pulsed amperometric detection (PAD) was optimised in order to quantify mannose, maltose, maltotriose, Maltotetraose, maltopentaose, maltohexaose and maltoheptaose content of beer. The method allows the determination of above mentioned oligosaccharides, in a single chromatographic run, without any pre-treatment. Limit of detection and limit of quantification were suitable for beer. Accuracy and repeatability were good for the entire amount considered. Once optimised HPAEC PAD for the specific matrix, the second goal of this research was to verify the possibility to discriminate beers, depending on their style. The carbohydrates content of brewpub commercial beers was very variable, ranging from 19.3 to 1469mg/L (mannose), 34.5 to 2882mg/L (maltose), 141.9 to 20731mg/L (maltotriose), 168.5 to 7650mg/L (Maltotetraose), 20.1 to 2537mg/L (maltopentaose), 22.9 to 3295mg/L (maltohexaose), 8.5 to 2492mg/L (maltoeptaose), even in the same style of beer. However, the carbohydrates content was useful, jointed with other compounds amount, to discriminate different styles of beer. As a matter of fact, principal component analysis put in evidence beer differences considering some fermentation conditions and colour.