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    Nuezhenide
    Information
    CAS No. 39011-92-2 Price $218 / 20mg
    Catalog No.CFN98623Purity>=98%
    Molecular Weight686.7 Type of CompoundIridoids
    FormulaC31H42O17Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Nuezhenide Description
    Source: The seeds of Ligustrum lucidum
    Biological Activity or Inhibitors: 1. Nuezhenide significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.
    2. Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect to the seeds of wheat and Chinese cabbage.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4562 mL 7.2812 mL 14.5624 mL 29.1248 mL 36.406 mL
    5 mM 0.2912 mL 1.4562 mL 2.9125 mL 5.825 mL 7.2812 mL
    10 mM 0.1456 mL 0.7281 mL 1.4562 mL 2.9125 mL 3.6406 mL
    50 mM 0.0291 mL 0.1456 mL 0.2912 mL 0.5825 mL 0.7281 mL
    100 mM 0.0146 mL 0.0728 mL 0.1456 mL 0.2912 mL 0.3641 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Nuezhenide References Information
    Citation [1]

    J Agric Food Chem. 2015 Feb 25;63(7):1990-5.

    Phenolic profile characterization of Chemlali olive stones by liquid chromatography-ion trap mass spectrometry.[Pubmed: 25650173]
    Aqueous methanol extracts of Chemlali olive stones were analyzed by reverse phase high-performance liquid chromatography (HPLC) with diode array detection and mass spectrometry [LC-MS/MS]. Oleoside, oleoside 11-methyl ester, Nuezhenide, oleoside 11-methyloleoside, Nuezhenide 11-methyloleoside, oleuropein, and glycosides of tryosol and hydroxytyrosol glycosides were identified in stones of Chemali olives. The antioxidant activity observed for the extract of the olive stones (IC50 = 13.84 μg/mL, TEAC = 0.436 mM) may be due to the high content of phenolic compounds, of which the main compounds are Nuezhenide (325.78 mg/100g), methoxy derivative of Nuezhenide (132.46 mg/100g), and Nuezhenide-11-methyloleoside (82.91 mg/100g). These results suggest the use of olive stones as sources of natural antioxidants.
    Citation [2]

    Planta Med., 2006, 72(1):62-4.

    A new neuroprotective compound of Ligustrum japonicum leaves.[Pubmed: 16450298 ]
    A new secoiridoid glycoside characterized as (8 Z)-Nuezhenide A along with five known glycosides, (8 E)-Nuezhenide, (8 Z)-Nuezhenide, oleoNuezhenide, osmanthuside B and osmanthuside D, were isolated from the n-BuOH fraction of Ligustrum japonicum leaves. All six compounds significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.
    Citation [3]

    Journal of Huzhou Teachers College, 1997(6):40-8.

    Studies on the Chemical Constituents of Germinant Inhibitor in the Fruits of Ligustrum Lucidum Ait.[Reference: WebLink]
    Nuezhenzi is the fruit of Ligustrum Lucidum Ait. that belongs in Olive Family. Germinant inhibition of the fruits had been discovered in recent years, and this effect can be applicable to solve some problems of agricultural production. But no any domestic or foreign articles have been pub-lished that discussed what is the main inhibitory constituent in the fruits. These studies were done by means of tracking activity , and a white powery compound was isolated from the aqueous substance of the fruits by the fractional extraction and purification method . It was identified as Nuezhenide on the basis of physical - chemical properties and IR. UV. and H1NMR. It was proven that the fruits contain several inhibitors and Nuezhenide is the main inhibitory compound. It shows a clear inhibitory effect to the seeds of wheat and Chinese cabbage in 2.5 × 10-3mol or even more during the observed period.