ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Acta Physiologiae Plantarum.2014 10.Molecules.2013 Nov 14;18(11):14105-21. Polytechnic University of Catalonia2016Arch Biochem Biophys. 2018 Jan 15;J Biochem Mol Toxicol. 2017 Jun 7
LWT - Food Science and Technology2017 Jan.Scientific Reports2015 August 26 J Ethnopharmacol. 2017 Jan 20;Int J Mol Med.2015 Dec 28.Microchemical JournalMarch 2018;
Int. J. of Food Properties08 Feb 2017;Yakugaku Zasshi.2018 Jan 30;Universidade Estadual Paulista2017;Evidence-Based Comp. & Alter. Med.Dec. 27, 2015
Our products had been exported to the following research institutions and universities, And still growing.
Universidad Industrial de Santan... (Colombia)University of Limpopo (South Africa)Chulalongkorn University (Thailand)University of Leipzig (Germany)
University of Padjajaran (Indonesia)University of Dicle (Turkey)Nicolaus Copernicus Uniwersity (Poland)Kyoto University (Japan)
Seoul National University of Sci... (Korea)Cancer Research Initatives Found... (Malaysia)Chiang Mai University (Thailand)
||Paederosidic acid has significant anti-tumor, anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain, and it up-regulates expressions of GAD 65, may be a promising future therapeutic agent for treatment of epilepsy.|
||Bcl-2/Bax | Caspase | Akt | JNK | GABA Receptor|
|Chem Biol Interact. 2017 May 1;269:33-40. |
|Antitumor activity of paederosidic acid in human non-small cell lung cancer cells via inducing mitochondria-mediated apoptosis.[Pubmed: 28185768]|
|This study was aimed to investigate antitumor activity of Paederosidic acid (PA) in human non-small cell lung cancer cells and explore the related mechanisms. |
METHODS AND RESULTS:
The anti-proliferative effects of PA on A549 cells were evaluated by MTT method and the IC50 values were calculated. Furthermore, the PA-induced apoptosis in A549 cells was determined by fluorescence microscope via staining with DAPI and by flow cytometer via staining with FITC conjugated Annexin V/PI. The expression of apoptosis-related or signaling proteins was investigated by Western blotting. Our results demonstrated that PA showed significant anti-tumor activity on lung cancer in vitro; the mechanisms were involved in inducing mitochondria-mediated apoptosis via up-regulation of caspase-3, caspase-8, caspase-9, Bid, Bax, down-regulation of Bcl-2 and stimulating the release of Cyto-C from mitochondria. In addition, JNK phosphorylation levels significantly increased concomitantly with decrease in Akt phosphorylation after treatment with PA in A549 cells. However, JNK siRNA-transfected cells diminished PA-induced caspase-3, 8 and 9, Bid and Bax activaton while enhanced the Bcl-2 activation.
Collectively, these results indicated that PA-induced JNK activation played an important functional role in apoptosis.
|Pharmacol Biochem Behav. 2013 Oct;111:97-101. |
|Anticonvulsant and sedative effects of paederosidic acid isolated from Paederia scandens (Lour.) Merrill. in mice and rats.[Pubmed: 24029464]|
|This study was designed to evaluate the anticonvulsant and sedative effects of Paederosidic acid isolated from Paederia scandens (Lour.) Merrill. in mice and rats. |
METHODS AND RESULTS:
In the present study, anticonvulsant activities of Paederosidic acid were evaluated by maximal electroshock and pentylenetetrazole-induced seizures in male mice. Then, pentobarbital sodium-induced sleeping time and locomotor activity tests in mice were used to evaluate the sedative effects of Paederosidic acid. Finally, the mechanism of Paederosidic acid was explored by evaluating the contents of Glu and GABA in the brain, and Western blot was used to measure GAD65 expression in the mouse brain. Paederosidic acid (5, 10, 20, and 40 mg/kg, ip) had significant anticonvulsant and sedative effects. Moreover, Paederosidic acid increased brain gamma-aminobutyric acid and decreased glutamic acid in the brain, and it up-regulated expressions of GAD 65.
In conclusion, our results suggest that Paederosidic acid may be a promising future therapeutic agent for treatment of epilepsy.
Paederosidic acid Description
||The herbs of Paederia scandens (Lour.) Merr
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.