ChemFaces is a professional high-purity natural products manufacturer.
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Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $652.6 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Ind Crops Prod.2014, 62:173-178Food Science and Biotechnology...2015...Analytical sci. & Tech2016, 186-193Acta Physiologiae Plantarum2016, 38:7Pharmacognosy Magazine...2017...Evid Based Complement Alternat Me...2017...Universite de Bordeaux...2017...Phytomedicine.2017, 24:77-86
J of L. Chroma.&Related Tech...2017...Hum Exp Toxicol.2017, 36(11):1169-1176BMC Complement Altern Med....2018...Biosci Rep.2018, 38(4)Plant Cell Physiol.2018, 59(1):128-141Pathogens.2018, 7(3):E62Front Pharmacol.2018, 9:756Nat Commun.2019, 10(1):5169
Analytical methods2019, 11(6)J Pharm Biomed Anal.2019, 164:119-127Journal of Oil Palm Research...2019...Pest Manag Sci.2019, 75(9):2530-2541Sci Rep.2019, 9(1):4342Oxid Med Cell Longev2019, 9056845:13Evid-Based Compl Alt2020, 7202519:13
Our products had been exported to the following research institutions and universities, And still growing.
University of Queensland (Australia)Mendel University in Brno (Czech Republic)University of Maryland (USA)Ain Shams University (Egypt)
Shanghai Institute of Biochemis... (China)Heidelberg University (Germany)Institute of Pathophysiology Me... (Austria)Institute of Bioorganic Chemist... (Poland)
Almansora University (Egypt)Uniwersytet Jagielloński w Kra... (Poland)Sant Gadge Baba Amravati Univer... (India)
Related Screening Libraries
||Polyporenic acid C shows inhibitory activity against human collagenase. Polyporenic acid C induces apoptosis through the death receptor-mediated apoptotic pathway where the activation of caspase-8 leads to the direct cleavage of execution caspases without the involvement of the mitochondria. |
||PARP | Caspase | PI3K | Akt | p53|
|Mol Carcinog. 2009 Jun;48(6):498-507. |
|Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells.[Pubmed: 18973184]|
|Lung cancer continues to be the leading cause of cancer-related mortality worldwide. This warrants the search for new and effective agents against lung cancer. We and others have recently shown that lanostane-type triterpenoids isolated from the fungal species Poria cocos (P. cocos) can inhibit cancer growth. However, the mechanisms responsible for the anticancer effects of these triterpenoids remain unclear. |
METHODS AND RESULTS:
In this study, we investigated the effect of Polyporenic acid C (PPAC), a lanostane-type triterpenoid from P. cocos, on the growth of A549 nonsmall cell lung cancer cells (NSCLC). The results demonstrate that PPAC significantly reduced cell proliferation via induction of apoptosis as evidenced by sub-G1 analysis, annexin V-FITC staining, and increase in cleavage of procaspase-8, -3, and poly(ADP-ribose)-polymerase (PARP). However, unlike our previously reported lanostane-type triterpenoid, pachymic acid, treatment of cells with PPAC was not accompanied by disruption of mitochondrial membrane potential and increase in cleavage of procaspase-9. Further, PPC-induced apoptosis was inhibited by caspase-8 and pan caspase inhibitors but not by a caspase-9 inhibitor. Taken together, the results suggest that PPAC induces apoptosis through the death receptor-mediated apoptotic pathway where the activation of caspase-8 leads to the direct cleavage of execution caspases without the involvement of the mitochondria. Furthermore, suppressed PI3-kinase/Akt signal pathway and enhanced p53 activation after PPAC treatment suggests this to be an additional mechanism for apoptosis induction.
Together, these results encourage further studies of PPAC as a promising candidate for lung cancer therapy.
Polyporenic acid C Description
||The roots of Wolfiporia cocos (Schw.) Ryv.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.