• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Polyporenic acid C
    Information
    CAS No. 465-18-9 Price $333 / 5mg
    Catalog No.CFN92739Purity>=98%
    Molecular Weight482.7Type of CompoundTriterpenoids
    FormulaC31H46O4Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Auckland (New Zealand)
  • Utrecht University (Netherlands)
  • Martin Luther University of Hall... (Germany)
  • Chinese University of Hong Kong (China)
  • Research Unit Molecular Epigenet... (Germany)
  • Ateneo de Manila University (Philippines)
  • Medizinische Universit?t Wien (Austria)
  • Auburn University (USA)
  • Calcutta University (India)
  • Charles University in Prague (Czech Republic)
  • University of Limpopo (South Africa)
  • More...
  • Package
    Featured Products
    3-O-Feruloylquinic acid

    Catalog No: CFN92393
    CAS No: 1899-29-2
    Price: $488/5mg
    Syringaresinol-di-O-glucoside

    Catalog No: CFN90458
    CAS No: 66791-77-3
    Price: $288/20mg
    Narcissoside

    Catalog No: CFN99773
    CAS No: 604-80-8
    Price: $188/20mg
    3,6'-Disinapoyl sucrose

    Catalog No: CFN90578
    CAS No: 139891-98-8
    Price: $138/20mg
    Scopolin

    Catalog No: CFN98887
    CAS No: 531-44-2
    Price: $168/20mg
    Biological Activity
    Description: 1. Polyporenic acid C shows inhibitory activity against human collagenase.
    2. Polyporenic acid C induces apoptosis through the death receptor-mediated apoptotic pathway where the activation of caspase-8 leads to the direct cleavage of execution caspases without the involvement of the mitochondria.
    Targets: PARP | Caspase | PI3K | Akt | p53
    Polyporenic acid C Description
    Source: The root of Wolfiporia cocos (Schw.) Ryv.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Hamaudol

    Catalog No: CFN95115
    CAS No: 735-46-6
    Price: $318/5mg
    Iridin

    Catalog No: CFN96557
    CAS No: 491-74-7
    Price: $188/20mg
    4,5-Dimethoxycanthin-6-one

    Catalog No: CFN99847
    CAS No: 18110-87-7
    Price: $333/5mg
    1,3,6-Trihydroxy-2-methylanthraqui...

    Catalog No: CFN95095
    CAS No: 87686-87-1
    Price: $218/10mg
    Pinoresinol

    Catalog No: CFN98775
    CAS No: 487-36-5
    Price: $268/20mg
    Iristectorin A

    Catalog No: CFN95037
    CAS No: 37744-61-9
    Price: $333/5mg
    Sibiricose A5

    Catalog No: CFN90645
    CAS No: 107912-97-0
    Price: $138/20mg
    Kaempferol 3-O-beta-(6''-p-coumaro...

    Catalog No: CFN95089
    CAS No: 111957-48-3
    Price: $338/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0717 mL 10.3584 mL 20.7168 mL 41.4336 mL 51.792 mL
    5 mM 0.4143 mL 2.0717 mL 4.1434 mL 8.2867 mL 10.3584 mL
    10 mM 0.2072 mL 1.0358 mL 2.0717 mL 4.1434 mL 5.1792 mL
    50 mM 0.0414 mL 0.2072 mL 0.4143 mL 0.8287 mL 1.0358 mL
    100 mM 0.0207 mL 0.1036 mL 0.2072 mL 0.4143 mL 0.5179 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Polyporenic acid C References Information
    Citation [1]

    Mol Carcinog. 2009 Jun;48(6):498-507.

    Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells.[Pubmed: 18973184]
    We investigated the effect of Polyporenic acid C (PPAC), a lanostane-type triterpenoid from P. cocos, on the growth of A549 nonsmall cell lung cancer cells (NSCLC). The results demonstrate that Polyporenic acid C significantly reduced cell proliferation via induction of apoptosis as evidenced by sub-G1 analysis, annexin V-FITC staining, and increase in cleavage of procaspase-8, -3, and poly(ADP-ribose)-polymerase (PARP). However, unlike our previously reported lanostane-type triterpenoid, pachymic acid, treatment of cells with Polyporenic acid C was not accompanied by disruption of mitochondrial membrane potential and increase in cleavage of procaspase-9. Further, Polyporenic acid C-induced apoptosis was inhibited by caspase-8 and pan caspase inhibitors but not by a caspase-9 inhibitor. Taken together, the results suggest that Polyporenic acid C induces apoptosis through the death receptor-mediated apoptotic pathway where the activation of caspase-8 leads to the direct cleavage of execution caspases without the involvement of the mitochondria. Furthermore, suppressed PI3-kinase/Akt signal pathway and enhanced p53 activation after Polyporenic acid C treatment suggests this to be an additional mechanism for apoptosis induction. Together, these results encourage further studies of Polyporenic acid C as a promising candidate for lung cancer therapy.