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    Polyporenic acid C
    Information
    CAS No. 465-18-9 Price $333 / 5mg
    Catalog No.CFN92739Purity>=98%
    Molecular Weight482.7Type of CompoundTriterpenoids
    FormulaC31H46O4Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Polyporenic acid C Description
    Source: The root of Wolfiporia cocos (Schw.) Ryv.
    Biological Activity or Inhibitors: 1. Polyporenic acid C shows inhibitory activity against human collagenase.
    2. Polyporenic acid C induces apoptosis through the death receptor-mediated apoptotic pathway where the activation of caspase-8 leads to the direct cleavage of execution caspases without the involvement of the mitochondria.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

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    doi: 10.3390/molecules22111829.

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0717 mL 10.3584 mL 20.7168 mL 41.4336 mL 51.792 mL
    5 mM 0.4143 mL 2.0717 mL 4.1434 mL 8.2867 mL 10.3584 mL
    10 mM 0.2072 mL 1.0358 mL 2.0717 mL 4.1434 mL 5.1792 mL
    50 mM 0.0414 mL 0.2072 mL 0.4143 mL 0.8287 mL 1.0358 mL
    100 mM 0.0207 mL 0.1036 mL 0.2072 mL 0.4143 mL 0.5179 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Polyporenic acid C References Information
    Citation [1]

    Mol Carcinog. 2009 Jun;48(6):498-507.

    Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells.[Pubmed: 18973184]
    We investigated the effect of Polyporenic acid C (PPAC), a lanostane-type triterpenoid from P. cocos, on the growth of A549 nonsmall cell lung cancer cells (NSCLC). The results demonstrate that Polyporenic acid C significantly reduced cell proliferation via induction of apoptosis as evidenced by sub-G1 analysis, annexin V-FITC staining, and increase in cleavage of procaspase-8, -3, and poly(ADP-ribose)-polymerase (PARP). However, unlike our previously reported lanostane-type triterpenoid, pachymic acid, treatment of cells with Polyporenic acid C was not accompanied by disruption of mitochondrial membrane potential and increase in cleavage of procaspase-9. Further, Polyporenic acid C-induced apoptosis was inhibited by caspase-8 and pan caspase inhibitors but not by a caspase-9 inhibitor. Taken together, the results suggest that Polyporenic acid C induces apoptosis through the death receptor-mediated apoptotic pathway where the activation of caspase-8 leads to the direct cleavage of execution caspases without the involvement of the mitochondria. Furthermore, suppressed PI3-kinase/Akt signal pathway and enhanced p53 activation after Polyporenic acid C treatment suggests this to be an additional mechanism for apoptosis induction. Together, these results encourage further studies of Polyporenic acid C as a promising candidate for lung cancer therapy.