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    Taccalonolide A
    Taccalonolide A
    CAS No. 108885-68-3 Price $288 / 10mg
    Catalog No.CFN90596Purity>=98%
    Molecular Weight702.74Type of CompoundSteroids
    FormulaC36H46O14Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Our products had been exported to the following research institutions and universities, And still growing.
  • The Institute of Cancer Research (United Kingdom)
  • Monash University Malaysia (Malaysia)
  • Cancer Research Initatives Found... (Malaysia)
  • Shanghai University of TCM (China)
  • Sapienza University of Rome (Italy)
  • Biotech R&D Institute (USA)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Technical University of Denmark (Denmark)
  • University of Limpopo (South Africa)
  • University of Toulouse (France)
  • Florida A&M University (USA)
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    Biological Activity
    Description: Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects.
    Targets: Bcl-2/Bax | Caspase | P-gp
    Taccalonolide A Description
    Source: The rhizomes of Schizocapsa plantaginea Hance
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    PMID: 29230013

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    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.423 mL 7.115 mL 14.23 mL 28.46 mL 35.575 mL
    5 mM 0.2846 mL 1.423 mL 2.846 mL 5.692 mL 7.115 mL
    10 mM 0.1423 mL 0.7115 mL 1.423 mL 2.846 mL 3.5575 mL
    50 mM 0.0285 mL 0.1423 mL 0.2846 mL 0.5692 mL 0.7115 mL
    100 mM 0.0142 mL 0.0712 mL 0.1423 mL 0.2846 mL 0.3558 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Kinase Assay:
    April 12, 2005
    Taccalonolide microtubule stabilizing agents[Reference: WebLink]
    In accordance with the present invention, there have been identified extracts from a tropical plant that initiate paclitaxel-like microtubule bundling.
    Bioassay-directed purification yields the steroid Taccalonolide A. Taccalonolide, like paclitaxel, initiates the formation of abnormal interphaes and mitotic microtubules. Cells treated with taccalonolide exhibit thick bundles of microtubules that appear to nucleate independent of the microtubule organizing center. Abnormal mitotic spindles consisting of multi-polar spindles are initiated by Taccalonolide And resemble abnormal mitotic spindles found in the presence of paclitaxel. Like paclitaxel, taccalonolide causes the breakdown of the nucleus into micronuclei. Taccalonolide causes G2/M arrest, Bc1-2 phosphorylation and initiates an apoptotic cascade that includes the activation of caspase 3. Taccalonolide is an effective inhibitor of proliferation against both SK-OV-3 and MDA-MB-435 cell with IC50 values of 2.3 μM and 2.1 μM respectively. In contrast to paclitaxel, taccalonolide is effective against the multidrug resistant SKVLB-1 cellline and thus appears to be a poor substrate for P-glycoprotein-mediated transport. Although taccalonolide is almost equipotent with paclitaxel in its effects on cellular microtubules, it is much less potent than paclitaxel in its ability to initiate the polymerization of purified tubulin and microtubule protein.
    Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects.