ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Org Biomol Chem. 2017 Jul 25.Phytother Res. 2016 Dec;Proc Natl Acad Sci U S A. 2016 Jul 26;Sci Rep. 2018 Jan 11;SBRAS2016(12)
Tumour Biol.2015 Apr 12.J. Agric. Food Chem.,2015, 63 (44), 9869–9878Food Research InternationalApr. 2018;Oncology LettersJan. 25, 2018;Evid Based Complement Alternat Med. 2016 May 24;
Mol. & Cell. ToxicologySep. 2017;Molecules 2016, 21(6), 739;2016 Jun 14;21(6). PLoS One. 2015 May 15.J Agric Food Chem.2018 Jan 10;
Our products had been exported to the following research institutions and universities, And still growing.
The Institute of Cancer Research (United Kingdom)Monash University Malaysia (Malaysia)Cancer Research Initatives Found... (Malaysia)Shanghai University of TCM (China)
Sapienza University of Rome (Italy)Biotech R&D Institute (USA)Centrum Menselijke Erfelijkheid (Belgium)Technical University of Denmark (Denmark)
University of Limpopo (South Africa)University of Toulouse (France)Florida A&M University (USA)
|| Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant
since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects.
||Bcl-2/Bax | Caspase | P-gp|
Taccalonolide A Description
||The rhizomes of Schizocapsa plantaginea Hance
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|April 12, 2005 |
|Taccalonolide microtubule stabilizing agents[Reference: WebLink]|
|In accordance with the present invention, there have been identified extracts from a tropical plant that initiate paclitaxel-like microtubule bundling. |
METHODS AND RESULTS:
Bioassay-directed purification yields the steroid Taccalonolide A. Taccalonolide, like paclitaxel, initiates the formation of abnormal interphaes and mitotic microtubules. Cells treated with taccalonolide exhibit thick bundles of microtubules that appear to nucleate independent of the microtubule organizing center. Abnormal mitotic spindles consisting of multi-polar spindles are initiated by Taccalonolide And resemble abnormal mitotic spindles found in the presence of paclitaxel. Like paclitaxel, taccalonolide causes the breakdown of the nucleus into micronuclei. Taccalonolide causes G2/M arrest, Bc1-2 phosphorylation and initiates an apoptotic cascade that includes the activation of caspase 3. Taccalonolide is an effective inhibitor of proliferation against both SK-OV-3 and MDA-MB-435 cell with IC50 values of 2.3 μM and 2.1 μM respectively. In contrast to paclitaxel, taccalonolide is effective against the multidrug resistant SKVLB-1 cellline and thus appears to be a poor substrate for P-glycoprotein-mediated transport. Although taccalonolide is almost equipotent with paclitaxel in its effects on cellular microtubules, it is much less potent than paclitaxel in its ability to initiate the polymerization of purified tubulin and microtubule protein.
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects.