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More articles cited ChemFaces products.
Antiviral Res.2013 Jun;98(3):386-93.Evid Based Complement Alternat Med. 2017:6360836.Phytochemistry Letters22 Dec. 2016Mediators Inflamm.2016:7216912. J. Soc. Cosmet. Sci. KoreaJune 2016
Anal Bioanal Chem. 2016 Jun;408(15)Tea Res. Ins. Of ChinaJuly 13, 2017;J. Acta Agr. Scandinavica17 Apr 2017J Breast Cancer2015 Jun;18(2):112-118.Anal Bioanal Chem.2018 Feb;
US20170000760 A1Jan 5, 2017Biochem Biophys Res Commun. 2018 Jan 1;Mol Cells.2015 Sep 30;38(9):765-72.Biol Pharm Bull.2017;40(6)
Our products had been exported to the following research institutions and universities, And still growing.
Universidade Federal de Goias (U... (Brazil)Seoul National University of Sci... (Korea)Leibniz-Institut für Pflanzenbi... (Germany)University of Madras (India)
University of East Anglia (United Kingdom)Siksha O Anusandhan University (India)University of Pretoria (South Africa)Indian Institute of Science (India)
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|| Valepotriates, a new class of cytotoxic and antitumor agents, they are very potent cytotoxic agents for the HTC hepatoma cells. Valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety. Valepotriate fraction can have sedative effects and affect behavioral parameters related to recognition memory.|
|Planta Med. 1981 Jan;41(1):21-8. |
|Valepotriates, a new class of cytotoxic and antitumor agents.[Pubmed: 7232547 ]|
METHODS AND RESULTS:
The following Valepotriates: valtrate and didrovaltrate, isolated from the roots of VALERIANA WALLICHII D. C., as well as baldrinal, a degradation product of the valtrate, were tested for their cytotoxic and antitumor activities, respectively IN VITRO on cultured rat hepatoma cells (HTC line), and IN VIVO, on female mice KREBS II ascitic tumors.
It appears that the three Valepotriates are very potent cytotoxic agents for the HTC hepatoma cells, and that the didrovaltrate induces a perceptible high per cent definitive remissions of the KREBS II ascitic tumors.
|Evid Based Complement Alternat Med. 2010 Jan 4. |
|A Valepotriate Fraction of Valeriana glechomifolia Shows Sedative and Anxiolytic Properties and Impairs Recognition But Not Aversive Memory in Mice.[Pubmed: 20047889]|
|Plants of the genus Valeriana (Valerianaceae) are used in traditional medicine as a mild sedative, antispasmodic and tranquilizer in many countries.
METHODS AND RESULTS:
This study was undertaken to explore the neurobehavioral effects of systemic administration of a Valepotriate extract fraction of known quantitative composition of Valeriana glechomifolia (endemic of southern Brazil) in mice. Adult animals were treated with a single intraperitoneal injection of Valepotriate fraction (VF) in the concentrations of 1, 3 or 10 mg kg(-1), or with vehicle in the pre-training period before each behavioral test. During the exploration of an open field, mice treated with 10 mg kg(-1) of Valepotriate fraction showed reduced locomotion and exploratory behavior. Although overall habituation sessions for locomotion and exploratory behavior among vehicle control and doses of Valepotriate fraction were not affected, comparison between open-field and habituation sessions within each treatment showed that Valepotriate fraction administration at 1 and 10 mg kg(-1) impaired habituation. In the elevated plus-maze test, mice treated with Valepotriate fraction (10 mg kg(-1)) showed a significant increase in the percentage of time spent in the open arms without significant effects in the number of total arm entries. Valepotriate fraction at 3 mg kg(-1) produced an impairment of novel-object recognition memory. In contrast, Valepotriate fraction did not affect fear-related memory assessed in an inhibitory avoidance task.
The results indicate that Valepotriate fraction can have sedative effects and affect behavioral parameters related to recognition memory.
|Phytother Res. 2002 Nov;16(7):650-4. |
|Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study.[Pubmed: 12410546]|
|The aim of the present study was to carry out a controlled pilot study on the putative anxiolytic effect of Valepotriates.
METHODS AND RESULTS:
Thirty-six outpatients with generalized anxiety disorder (DSM III-R), after a 2-week wash-out, were randomized to one of the following three treatments for 4 weeks (n = 12 per group): Valepotriates (mean daily dose: 81.3 mg), diazepam (mean daily dose: 6.5 mg), or placebo. A parallel, double-blind, flexible-dose, placebo-controlled design was employed. No significant difference was observed among the three groups at baseline or in the change from baseline on the Hamilton anxiety scale (HAM-A) or in the trait part of the state-trait anxiety inventory (STAI-trait). Moreover, the three groups presented a significant reduction in the total HAM-A scores. On the other hand, only the diazepam and Valepotriates groups showed a significant reduction in the psychic factor of HAM-A. The diazepam group also presented a significant reduction of the STAI-trait.
Although the principal analysis (HAM-A between group comparison) found negative results (probably due to the small sample size in each group), the preliminary data obtained in the present study suggest that the Valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety.
However, since the number of subjects per group was very small, the present results must be viewed as preliminary.
Thus, further studies addressing this issue are warranted.
||The roots of Valeriana officinalis L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
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* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Nat Prod. 1985 Jan-Feb;48(1):17-21. |
|Valepotriate production of normal and colchicine-treated cell suspension cultures of Valeriana wallichii.[Pubmed: 4009183]|
Colchicine-treated suspension cultures of Valeriana wallichii produce higher amounts of Valepotriates than did the respective untreated cultures.
METHODS AND RESULTS:
The ability to produce Valepotriates in the treated culture remains in the absence of colchicine even if the chromosome status returns to normal. When the colchicine treatment is repeated, a further increase in Valepotriate production can be obtained. Besides known Valepotriates, a series of fourteen new compounds, hitherto not described for the parent plant, were isolated from the cell suspension culture.
Eight of them are also found in plant parts in minor amounts, but six seem to be present only in tissue cultures of V. wallichii.