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    Valepotriate
    Information
    CAS No. 18296-44-1 Price $298 / 20mg
    Catalog No.CFN90205Purity>=98%
    Molecular Weight422.47Type of CompoundIridoids
    FormulaC22H30NO8Physical DescriptionOil
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Valepotriates, a new class of cytotoxic and antitumor agents, they are very potent cytotoxic agents for the HTC hepatoma cells. Valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety. Valepotriate fraction can have sedative effects and affect behavioral parameters related to recognition memory.
    In vitro:
    Planta Med. 1981 Jan;41(1):21-8.
    Valepotriates, a new class of cytotoxic and antitumor agents.[Pubmed: 7232547 ]

    METHODS AND RESULTS:
    The following Valepotriates: valtrate and didrovaltrate, isolated from the roots of VALERIANA WALLICHII D. C., as well as baldrinal, a degradation product of the valtrate, were tested for their cytotoxic and antitumor activities, respectively IN VITRO on cultured rat hepatoma cells (HTC line), and IN VIVO, on female mice KREBS II ascitic tumors.
    CONCLUSIONS:
    It appears that the three Valepotriates are very potent cytotoxic agents for the HTC hepatoma cells, and that the didrovaltrate induces a perceptible high per cent definitive remissions of the KREBS II ascitic tumors.
    In vivo:
    Evid Based Complement Alternat Med. 2010 Jan 4.
    A Valepotriate Fraction of Valeriana glechomifolia Shows Sedative and Anxiolytic Properties and Impairs Recognition But Not Aversive Memory in Mice.[Pubmed: 20047889]
    Plants of the genus Valeriana (Valerianaceae) are used in traditional medicine as a mild sedative, antispasmodic and tranquilizer in many countries.
    METHODS AND RESULTS:
    This study was undertaken to explore the neurobehavioral effects of systemic administration of a Valepotriate extract fraction of known quantitative composition of Valeriana glechomifolia (endemic of southern Brazil) in mice. Adult animals were treated with a single intraperitoneal injection of Valepotriate fraction (VF) in the concentrations of 1, 3 or 10 mg kg(-1), or with vehicle in the pre-training period before each behavioral test. During the exploration of an open field, mice treated with 10 mg kg(-1) of Valepotriate fraction showed reduced locomotion and exploratory behavior. Although overall habituation sessions for locomotion and exploratory behavior among vehicle control and doses of Valepotriate fraction were not affected, comparison between open-field and habituation sessions within each treatment showed that Valepotriate fraction administration at 1 and 10 mg kg(-1) impaired habituation. In the elevated plus-maze test, mice treated with Valepotriate fraction (10 mg kg(-1)) showed a significant increase in the percentage of time spent in the open arms without significant effects in the number of total arm entries. Valepotriate fraction at 3 mg kg(-1) produced an impairment of novel-object recognition memory. In contrast, Valepotriate fraction did not affect fear-related memory assessed in an inhibitory avoidance task.
    CONCLUSIONS:
    The results indicate that Valepotriate fraction can have sedative effects and affect behavioral parameters related to recognition memory.
    Phytother Res. 2002 Nov;16(7):650-4.
    Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study.[Pubmed: 12410546]
    The aim of the present study was to carry out a controlled pilot study on the putative anxiolytic effect of Valepotriates.
    METHODS AND RESULTS:
    Thirty-six outpatients with generalized anxiety disorder (DSM III-R), after a 2-week wash-out, were randomized to one of the following three treatments for 4 weeks (n = 12 per group): Valepotriates (mean daily dose: 81.3 mg), diazepam (mean daily dose: 6.5 mg), or placebo. A parallel, double-blind, flexible-dose, placebo-controlled design was employed. No significant difference was observed among the three groups at baseline or in the change from baseline on the Hamilton anxiety scale (HAM-A) or in the trait part of the state-trait anxiety inventory (STAI-trait). Moreover, the three groups presented a significant reduction in the total HAM-A scores. On the other hand, only the diazepam and Valepotriates groups showed a significant reduction in the psychic factor of HAM-A. The diazepam group also presented a significant reduction of the STAI-trait.
    CONCLUSIONS:
    Although the principal analysis (HAM-A between group comparison) found negative results (probably due to the small sample size in each group), the preliminary data obtained in the present study suggest that the Valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety. However, since the number of subjects per group was very small, the present results must be viewed as preliminary. Thus, further studies addressing this issue are warranted.
    Valepotriate Description
    Source: The roots of Valeriana officinalis L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.367 mL 11.8352 mL 23.6703 mL 47.3406 mL 59.1758 mL
    5 mM 0.4734 mL 2.367 mL 4.7341 mL 9.4681 mL 11.8352 mL
    10 mM 0.2367 mL 1.1835 mL 2.367 mL 4.7341 mL 5.9176 mL
    50 mM 0.0473 mL 0.2367 mL 0.4734 mL 0.9468 mL 1.1835 mL
    100 mM 0.0237 mL 0.1184 mL 0.2367 mL 0.4734 mL 0.5918 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Cell Research:
    J Nat Prod. 1985 Jan-Feb;48(1):17-21.
    Valepotriate production of normal and colchicine-treated cell suspension cultures of Valeriana wallichii.[Pubmed: 4009183]
    Colchicine-treated suspension cultures of Valeriana wallichii produce higher amounts of Valepotriates than did the respective untreated cultures.
    METHODS AND RESULTS:
    The ability to produce Valepotriates in the treated culture remains in the absence of colchicine even if the chromosome status returns to normal. When the colchicine treatment is repeated, a further increase in Valepotriate production can be obtained. Besides known Valepotriates, a series of fourteen new compounds, hitherto not described for the parent plant, were isolated from the cell suspension culture.
    CONCLUSIONS:
    Eight of them are also found in plant parts in minor amounts, but six seem to be present only in tissue cultures of V. wallichii.