Natural Products
Alstonine
| Catalog No. | CFN97709 |  |
| CAS No. | 642-18-2 | |
| Molecular Weight: | 349.4 | |
| Molecular Formula | C21H21N2O3 | |
| DBs | [PubChem]:274952787 [ChEMBL]:2612 [PCIDB]: |
Standard InChI:
InChI=1S/C21H20N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-8,11-12,15-16H,9-10H2,1-2H3/p+1/t12-,15-,16-/m0/s1
Biological Activity
Alstonine has antipsychotic-like effects, can prevent MK801-induced working memory deficit and is also effective in counteracting MK801-induced hyperlocomotion and social interaction deficit , indicating its potential benefit for cognitive deficits now seen as a core symptom in the disease; 5-HT 2A/C receptors are central to the antipsychotic-like effects of alstonine, consistently seen in mouse models relevant to the three dimensions of schizophrenia symptoms.[1]
Alstonine is a potential fluorescent marker for tiny tumor detection and imaging.[2]
Product
References
[1] Linck V M, Bessa M M, Herrmann A P, et al. Prog Neuro-Psychoph, 2012, 36(1):29-33.
[2] Vodinh T. Proc Spie, 1997, 2976:332-40.
[3] Huang P, Li W J, He B T. Chinese journal of experimental formulas of Chinese medicine, 2014, 20 (1) : 66-9.
Product Use Citation
