Natural Products
alpha-Cyperone
| Catalog No. | CFN99703 |  |
| CAS No. | 473-08-5 | |
| Molecular Weight: | 218.33 | |
| Molecular Formula | C15H22O | |
| DBs | [PubChem]:274950450 [ChEMBL]:80919 [PCIDB]:12759 |
Standard InChI:
InChI=1S/C15H22O/c1-10(2)12-5-7-15(4)8-6-14(16)11(3)13(15)9-12/h12H,1,5-9H2,2-4H3/t12-,15+/m1/s1
Biological Activity
Alpha-cyperone, a major active compound of Cyperus rotundus, has anti-inflammatory effects with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFκB pathway in LPS-stimulated RAW 264.7 cells.[1]
In the presence of subinhibitory concentrations of alpha-cyperone, Hla production was markedly inhibited, and alpha-cyperone protects lung cells from Hla-induced injury , indicate that alpha-cyperone is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium, it may provide the basis for a new strategy to combat S. aureus pneumonia.[2]
Alpha-cyperone inhibits the expression of inflammatory and coagulant mediators via mitogen-activated protein kinase (MAPKs) and NF-kappa B signaling pathways, it may contribute to future research on the action mechanisms , as well as therapy for inflammation- or coagulation-related diseases.[3]
Product
References
[1] Jung S H, Su J K, Jun B G, et al. J Ethnopharmacol, 2013, 147(1):208-14.
[2] Luo M. J Microbiol Biotech. 2012, 22(8):1170-6.
[3] Fan, Qiao-Jia, Jiang, et al. Immunopharm Immunot, 2013, 35(2):215-24.
[4] Liang C, Luo Y, Zhong Z, et al. J Chinese Medicinal Materials, 2004, 27(8):578-9.
Product Use Citation
