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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $20.7 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Institute of Food Science & Techn...2021...Nutrients.2021, 13(3):978. Int J Biol Macromol....2020...Pharm Biol.2022, 60(1):2040-2048.Korean J. of Food Sci. and Tech...2016...Molecules.2021, 26(23):7390. Phytomedicine.2019, 57:95-104J Separation Science & Technology...2016...
Asian Journal of Chemistry...2014...Mol Divers.2022, s11030-022-10586-3.Biomedicines.2022, 10(5):1170J Anal Methods Chem.2022, 2022:2229500.Chemistry of Plant Raw Materials...2019...Appl. Sci.2021, 11(24),12080Molecules.2017, 22(11)Chinese J of Tissue Engineering R...2022...
Oncology Letters2018, 4690-4696Drug Chem Toxicol.2020, 1-14. Phytother Res.2019, 33(3):676-689Scientific World Journal....2014...Vietnam J. Chemistry2022, 60(2):211-222JABS2020, 14:2(2020)Food Chem.2019, 279:80-87
Our products had been exported to the following research institutions and universities, And still growing.
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
J Med Food.2016, 19(12):1155-1165In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.Preprints2021, doi:10.20944Int J Mol Sci.2019, 20(16):E4015Journal of Life Science2017, 233-240Plants (Basel).2021, 10(2):278. BMC Complement Altern Med.2019, 19(1):339Food Chem.2019, 278:683-691J Agric Food Chem.2018, 66(1):351-358Processes2021, 9(11),2065.
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
|| Sparteine is a strong inhibitor of mephenytoin p-hydroxylation.|
||The herbs of Parochetus communis
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Pharmacogenetics, 1993, 3(5):256-263. |
|Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.[Reference: WebLink]|
METHODS AND RESULTS:
Human liver preparations were used to screen various drugs for their capability of binding to mephenytoin p-hydroxylase and Sparteine monooxygenase, two cytochrome P-450-catalyzed activities that are independently heritable. For this screening, any indication of competitive inhibition by the drug was interpreted as an indication of binding. Among 64 drugs and alkaloids tested, 24 compounds caused inhibition of mephenytoin p-hydroxylation but the inhibition was weak in most cases; by contrast, 40 of the 64 compounds inhibited Sparteine oxidation, the inhibition being potent in many cases. The only fairly strong inhibitors of mephenytoin p-hydroxylation were the alkaloid papaverine and the monoamine oxidase inhibitors tranylcypromine and nialamide.
The results of these inhibition studies confirm the independence of the two monogenic defects observed in different populations. Metabolism is possibly altered in poor metabolizers of mephenytoin with fewer drugs than in poor metabolizers of Sparteine.
|Pure & Applied Chemistry, 1994, 66(7):1479--1486. |
|Enantioselective synthesis via sparteine-induced asymmetric deprotonation.[Reference: WebLink]|
METHODS AND RESULTS:
The deprotonation of achiral alkyl carbamates with sec-butyllithium/(-)-Sparteine proceeds with a high degree of chiral recognition to form substituted alcohols usually with ≥ 95 % ee after reaction with electrophiles followed by de-protection. The stereoselection is kinetically controlled and a qualitative transition state model is proposed. Some studies, concerning the discrimination between both enantiomers of stereogenic alkyl carbamates and on its utilization for the kinetic resolution are reported. The competition between external and internal competition was investigated in few cases.
Finally, we disclose a short report on the enantio¬selective electrophilic substitution of 1-methylindene; here the origin of stereo-selection is an thermodynamically driven epimerization of diastereomeric indenyllithium Sparteine complexes.
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