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Sparteine
Sparteine
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CAS No. 90-39-1 Price $70 / 20mg
Catalog No.CFN70216Purity>=98%
Molecular Weight234.3Type of CompoundAlkaloids
FormulaC15H26N2Physical DescriptionPowder
Download COA    MSDSSimilar structuralComparison
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    Sparteine

    Sparteine
    Product Name Sparteine
    CAS No.: 90-39-1
    Catalog No.: CFN70216
    Molecular Formula: C15H26N2
    Molecular Weight: 234.3 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Source: The herbs of Parochetus communis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $70 / 20mg
    Download: COA    MSDS
    Similar structural: Comparison
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    product package
  • J Med Food.2016, 19(12):1155-1165
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
    Biological Activity
    Description: Sparteine is a strong inhibitor of mephenytoin p-hydroxylation.
    Sparteine Description
    Source: The herbs of Parochetus communis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
    5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
    10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
    50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
    100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Pharmacogenetics, 1993, 3(5):256-263.
    Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.[Reference: WebLink]

    METHODS AND RESULTS:
    Human liver preparations were used to screen various drugs for their capability of binding to mephenytoin p-hydroxylase and Sparteine monooxygenase, two cytochrome P-450-catalyzed activities that are independently heritable. For this screening, any indication of competitive inhibition by the drug was interpreted as an indication of binding. Among 64 drugs and alkaloids tested, 24 compounds caused inhibition of mephenytoin p-hydroxylation but the inhibition was weak in most cases; by contrast, 40 of the 64 compounds inhibited Sparteine oxidation, the inhibition being potent in many cases. The only fairly strong inhibitors of mephenytoin p-hydroxylation were the alkaloid papaverine and the monoamine oxidase inhibitors tranylcypromine and nialamide.
    CONCLUSIONS:
    The results of these inhibition studies confirm the independence of the two monogenic defects observed in different populations. Metabolism is possibly altered in poor metabolizers of mephenytoin with fewer drugs than in poor metabolizers of Sparteine.
    Structure Identification:
    Pure & Applied Chemistry, 1994, 66(7):1479--1486.
    Enantioselective synthesis via sparteine-induced asymmetric deprotonation.[Reference: WebLink]

    METHODS AND RESULTS:
    The deprotonation of achiral alkyl carbamates with sec-butyllithium/(-)-Sparteine proceeds with a high degree of chiral recognition to form substituted alcohols usually with ≥ 95 % ee after reaction with electrophiles followed by de-protection. The stereoselection is kinetically controlled and a qualitative transition state model is proposed. Some studies, concerning the discrimination between both enantiomers of stereogenic alkyl carbamates and on its utilization for the kinetic resolution are reported. The competition between external and internal competition was investigated in few cases.
    CONCLUSIONS:
    Finally, we disclose a short report on the enantio¬selective electrophilic substitution of 1-methylindene; here the origin of stereo-selection is an thermodynamically driven epimerization of diastereomeric indenyllithium Sparteine complexes.
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