13-Oxo-9E,11E-octadecadienoic acid | CAS:29623-29-8

13-Oxo-9E,11E-octadecadienoic acid

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Description:

13-Oxo-9E,11E-octadecadienoic acid has antitumor activity.

In vitro:

Journal of Chromatography A, 2017, 1487:162-167.

Screening and analysis of potential anti-tumor components from the stipe of Ganoderma sinense using high-performance liquid chromatography/time-of-flight mass spectrometry with multivariate statistical tool.[Reference: WebLink]

According to Chinese Pharmacopoeia 2015 edition, Ganoderma (Lingzhi) is a species complex that comprise of Ganoderma lucidum and Ganoderma sinense. The bioactivity and chemical composition of G. lucidium had been studied extensively, and it was shown to possess antitumor activities in pharmacological studies. In contrast, G. sinense has not been studied in great detail. Our previous studies found that the stipe of G. sinense exhibited more potent antitumor activity than the pileus.
METHODS AND RESULTS:
To identify the antitumor compounds in the stipe of G. sinense, we studied its chemical components by merging the bioactivity results with liquid chromatography-mass spectrometry-based chemometrics.The stipe of G. sinense was extracted with water, followed by ethanol precipitation and liquid–liquid partition. The resulting residue was fractionated using column chromatography. The antitumor activity of these fractions were analysed using MTT assay in murine breast tumor 4T1 cells, and their chemical components were studied using the LC-QTOF-MS with multivariate statistical tools. The chemometric and MS/MS analysis correlated bioactivity with five known cytotoxic compounds, 4-hyroxyphenylacetate, 9-oxo-(10E,12E)-octadecadienoic acid, 3-phenyl-2-propenoic acid, 13-Oxo-9E,11E-octadecadienoic acid and lingzhine C, from the stipe of G. sinense.
CONCLUSIONS:
To the best of our knowledge, 4-hyroxyphenylacetate, 3-phenyl-2-propenoic acid and lingzhine C are firstly reported to be found in G. sinense. These five compounds will be investigated for their antitumor activities in the future.

13-Oxo-9E,11E-octadecadienoic acid Description

Source:	The leaves of Artemisia argyi
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

CAS No.	29623-29-8	Price	$368 / 5mg
Catalog No.	CFN80102	Purity	>=98%
Molecular Weight	294.43	Type of Compound	Lipids
Formula	C₁₈H₃₀O₃	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison

Product Name	13-Oxo-9E,11E-octadecadienoic acid
CAS No.:	29623-29-8
Catalog No.:	CFN80102
Molecular Formula:	C₁₈H₃₀O₃
Molecular Weight:	294.43 g/mol
Purity:	>=98%
Type of Compound:	Lipids
Physical Desc.:	Powder
Source:	The leaves of Artemisia argyi
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$368 / 5mg
Download:	COA MSDS
Similar structural:	Comparison

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3964 mL	16.982 mL	33.9639 mL	67.9279 mL	84.9098 mL
5 mM	0.6793 mL	3.3964 mL	6.7928 mL	13.5856 mL	16.982 mL
10 mM	0.3396 mL	1.6982 mL	3.3964 mL	6.7928 mL	8.491 mL
50 mM	0.0679 mL	0.3396 mL	0.6793 mL	1.3586 mL	1.6982 mL
100 mM	0.034 mL	0.1698 mL	0.3396 mL	0.6793 mL	0.8491 mL

CFN00089	Homopahutoxin	109777-68-6	414.7	C₂₄H₄₈NO₄+
CFN89446	6-Deoxyisojacareubin	26486-92-0	310.30	C₁₈H₁₄O₅
CFN90749	Rhapontigenin 3'-O-glucoside	94356-22-6	420.4	C₂₁H₂₄O₉
CFN96454	Vibralactone D	1251748-32-9	210.27	C₁₂H₁₈O₃

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
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