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2,4,6-Trihydroxybenzoic acid
2,4,6-Trihydroxybenzoic acid
Information
CAS No. 83-30-7 Price $30 / 20mg
Catalog No.CFN70208Purity>=98%
Molecular Weight170.1Type of CompoundPhenols
FormulaC7H6O5Physical DescriptionPowder
Download COA    MSDSSimilar structuralComparison
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    2,4,6-Trihydroxybenzoic acid

    2,4,6-Trihydroxybenzoic acid
    Product Name 2,4,6-Trihydroxybenzoic acid
    CAS No.: 83-30-7
    Catalog No.: CFN70208
    Molecular Formula: C7H6O5
    Molecular Weight: 170.1 g/mol
    Purity: >=98%
    Type of Compound: Phenols
    Physical Desc.: Powder
    Targets: CDK | p21
    Source: The water-extract of Penthorum chinense Pursh
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $30 / 20mg
    Download: COA    MSDS
    Similar structural: Comparison
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    product package
  • Molecules.2019, 24(6):E1155
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
    Biological Activity
    Description: 2,4,6-Trihydroxybenzoic acid may mediate its effects through a CDK- and SLC5A8-dependent pathway contributing to the prevention of colorectal cancer.
    Targets: CDK | p21
    2,4,6-Trihydroxybenzoic acid Description
    Source: The water-extract of Penthorum chinense Pursh
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.8789 mL 29.3945 mL 58.7889 mL 117.5779 mL 146.9724 mL
    5 mM 1.1758 mL 5.8789 mL 11.7578 mL 23.5156 mL 29.3945 mL
    10 mM 0.5879 mL 2.9394 mL 5.8789 mL 11.7578 mL 14.6972 mL
    50 mM 0.1176 mL 0.5879 mL 1.1758 mL 2.3516 mL 2.9394 mL
    100 mM 0.0588 mL 0.2939 mL 0.5879 mL 1.1758 mL 1.4697 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Cancers, 2019,11(3):427.
    The Flavonoid Metabolite 2,4,6-Trihydroxybenzoic Acid Is a CDK Inhibitor and an Anti-Proliferative Agent: A Potential Role in Cancer Prevention.[Reference: WebLink]
    Flavonoids have emerged as promising compounds capable of preventing colorectal cancer (CRC) due to their anti-oxidant and anti-inflammatory properties. It is hypothesized that the metabolites of flavonoids are primarily responsible for the observed anti-cancer effects owing to the unstable nature of the parent compounds and their degradation by colonic microflora.
    METHODS AND RESULTS:
    In this study, we investigated the ability of one metabolite, 2,4,6-Trihydroxybenzoic acid (2,4,6-THBA) to inhibit Cyclin Dependent Kinase (CDK) activity and cancer cell proliferation. Using in vitro kinase assays, we demonstrated that 2,4,6-THBA dose-dependently inhibited CDKs 1, 2 and 4 and in silico studies identified key amino acids involved in these interactions. Interestingly, no significant CDK inhibition was observed with the structurally related compounds 3,4,5-trihydroxybenzoic acid (3,4,5-THBA) and phloroglucinol, suggesting that orientation of the functional groups and specific amino acid interactions may play a role in inhibition. We showed that cellular uptake of 2,4,6-THBA required the expression of functional SLC5A8, a monocarboxylic acid transporter. Consistent with this, in cells expressing functional SLC5A8, 2,4,6-THBA induced CDK inhibitory proteins p21Cip1 and p27Kip1 and inhibited cell proliferation.
    CONCLUSIONS:
    These findings, for the first time, suggest that the flavonoid metabolite 2,4,6-THBA may mediate its effects through a CDK- and SLC5A8-dependent pathway contributing to the prevention of CRC.
    Structure Identification:
    China Journal of Chinese Materia Medica, 2001, 26(4):260-262.
    Studies on chemical constitutents from Penthorum chinense Pursh.[Reference: WebLink]
    To study the chemical constituents of Penthorum chinense.
    METHODS AND RESULTS:
    Silica gel and macroporous resin were used as adsorbent for isolation and purification. The chemical structures were elucidated by spectral analysis and chemical methods.Three compounds were isolated from the water-extract of P. chinense. The structures were identified as 5-hydroxy-flavanone-7-O-β-D-glucoside (Ⅰ), 2,4,6-Trihydroxybenzoic acid (Ⅱ) and quercetin(Ⅲ), respectively.
    CONCLUSIONS:
    Compounds Ⅰ and Ⅱ were isolated from this plant for the first time.
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