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More articles cited ChemFaces products.
Psychopharmacology (Berl).2020, 10.1007Srinagarind Medical Journal2017, 32(1)Antioxidants.2022, 11(4), 67.J Ethnopharmacol.2016, 194:219-227Current Traditional Medicine, ...2021...Research Square2021, March 3rd.LWT2021, 138:110397.Drug Des Devel Ther.2020, 14:5189-5204.
Front Pharmacol.2017, 8:673Int J Mol Sci.2022, 23(1):538.J Cell Mol Med.2021, 25(5):2645-2654. Molecules.2020, 25(3):734Phytomedicine.2021, 93:153796.Journal of Research in Pharmacy....2022...Antioxidants (Basel)....2021...J Agric Food Chem....2022...
Processes2021, 9(1), 153.Appl. Sci.2022, 12(4), 2032.Academic J of Second Military Med...2018...Plant Direct.2021, 5(4):e00318.Pharmacognosy Journal....2020...Food Addit Contam Part A....2021...Int J Mol Sci.2021, 22(16):8604.
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Molecules.2019, 24(6):E1155Antioxidants (Basel).2021, 10(10):1620.Asian J Beauty Cosmetol2016, 14(3):249-257Cancer Sci.2022, 113(4):1406-1416. LWT-Food Science and Technology2017, 75:488-496Biochemistry.2018, 57(40):5886-5896Molecules. 2013, 18(11):14105-21J Cancer.2019, 10(23):5843-5851Front Microbiol.2021, 12:736780.Int J Mol Sci.2018, 19(9):E2825
Related Screening Libraries
|| 2,4,6-Trihydroxybenzoic acid may mediate its effects through a CDK- and SLC5A8-dependent pathway contributing to the prevention of colorectal cancer.|
||CDK | p21|
2,4,6-Trihydroxybenzoic acid Description
||The water-extract of Penthorum chinense Pursh
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Cancers, 2019,11(3):427. |
|The Flavonoid Metabolite 2,4,6-Trihydroxybenzoic Acid Is a CDK Inhibitor and an Anti-Proliferative Agent: A Potential Role in Cancer Prevention.[Reference: WebLink]|
|Flavonoids have emerged as promising compounds capable of preventing colorectal cancer (CRC) due to their anti-oxidant and anti-inflammatory properties. It is hypothesized that the metabolites of flavonoids are primarily responsible for the observed anti-cancer effects owing to the unstable nature of the parent compounds and their degradation by colonic microflora.
METHODS AND RESULTS:
In this study, we investigated the ability of one metabolite, 2,4,6-Trihydroxybenzoic acid (2,4,6-THBA) to inhibit Cyclin Dependent Kinase (CDK) activity and cancer cell proliferation. Using in vitro kinase assays, we demonstrated that 2,4,6-THBA dose-dependently inhibited CDKs 1, 2 and 4 and in silico studies identified key amino acids involved in these interactions. Interestingly, no significant CDK inhibition was observed with the structurally related compounds 3,4,5-trihydroxybenzoic acid (3,4,5-THBA) and phloroglucinol, suggesting that orientation of the functional groups and specific amino acid interactions may play a role in inhibition. We showed that cellular uptake of 2,4,6-THBA required the expression of functional SLC5A8, a monocarboxylic acid transporter. Consistent with this, in cells expressing functional SLC5A8, 2,4,6-THBA induced CDK inhibitory proteins p21Cip1 and p27Kip1 and inhibited cell proliferation.
These findings, for the first time, suggest that the flavonoid metabolite 2,4,6-THBA may mediate its effects through a CDK- and SLC5A8-dependent pathway contributing to the prevention of CRC.
| China Journal of Chinese Materia Medica, 2001, 26(4):260-262. |
|Studies on chemical constitutents from Penthorum chinense Pursh.[Reference: WebLink]|
|To study the chemical constituents of Penthorum chinense.|
METHODS AND RESULTS:
Silica gel and macroporous resin were used as adsorbent for isolation and purification. The chemical structures were elucidated by spectral analysis and chemical methods.Three compounds were isolated from the water-extract of P. chinense. The structures were identified as 5-hydroxy-flavanone-7-O-β-D-glucoside (Ⅰ), 2,4,6-Trihydroxybenzoic acid (Ⅱ) and quercetin(Ⅲ), respectively.
Compounds Ⅰ and Ⅱ were isolated from this plant for the first time.
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