2,4,6-Trihydroxybenzoic acid | CAS:83-30-7

2,4,6-Trihydroxybenzoic acid

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2,4,6-Trihydroxybenzoic acid Description

Source:	The water-extract of Penthorum chinense Pursh
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Kinase Assay:

Cancers, 2019,11(3):427.

The Flavonoid Metabolite 2,4,6-Trihydroxybenzoic Acid Is a CDK Inhibitor and an Anti-Proliferative Agent: A Potential Role in Cancer Prevention.[Reference: WebLink]

Flavonoids have emerged as promising compounds capable of preventing colorectal cancer (CRC) due to their anti-oxidant and anti-inflammatory properties. It is hypothesized that the metabolites of flavonoids are primarily responsible for the observed anti-cancer effects owing to the unstable nature of the parent compounds and their degradation by colonic microflora.
METHODS AND RESULTS:
In this study, we investigated the ability of one metabolite, 2,4,6-Trihydroxybenzoic acid (2,4,6-THBA) to inhibit Cyclin Dependent Kinase (CDK) activity and cancer cell proliferation. Using in vitro kinase assays, we demonstrated that 2,4,6-THBA dose-dependently inhibited CDKs 1, 2 and 4 and in silico studies identified key amino acids involved in these interactions. Interestingly, no significant CDK inhibition was observed with the structurally related compounds 3,4,5-trihydroxybenzoic acid (3,4,5-THBA) and phloroglucinol, suggesting that orientation of the functional groups and specific amino acid interactions may play a role in inhibition. We showed that cellular uptake of 2,4,6-THBA required the expression of functional SLC5A8, a monocarboxylic acid transporter. Consistent with this, in cells expressing functional SLC5A8, 2,4,6-THBA induced CDK inhibitory proteins p21Cip1 and p27Kip1 and inhibited cell proliferation.
CONCLUSIONS:
These findings, for the first time, suggest that the flavonoid metabolite 2,4,6-THBA may mediate its effects through a CDK- and SLC5A8-dependent pathway contributing to the prevention of CRC.

Structure Identification:

China Journal of Chinese Materia Medica, 2001, 26(4):260-262.

Studies on chemical constitutents from Penthorum chinense Pursh.[Reference: WebLink]

To study the chemical constituents of Penthorum chinense.
METHODS AND RESULTS:
Silica gel and macroporous resin were used as adsorbent for isolation and purification. The chemical structures were elucidated by spectral analysis and chemical methods.Three compounds were isolated from the water-extract of P. chinense. The structures were identified as 5-hydroxy-flavanone-7-O-β-D-glucoside (Ⅰ), 2,4,6-Trihydroxybenzoic acid (Ⅱ) and quercetin(Ⅲ), respectively.
CONCLUSIONS:
Compounds Ⅰ and Ⅱ were isolated from this plant for the first time.

CAS No.	83-30-7	Price	$30 / 20mg
Catalog No.	CFN70208	Purity	>=98%
Molecular Weight	170.1	Type of Compound	Phenols
Formula	C₇H₆O₅	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison

Product Name	2,4,6-Trihydroxybenzoic acid
CAS No.:	83-30-7
Catalog No.:	CFN70208
Molecular Formula:	C₇H₆O₅
Molecular Weight:	170.1 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Targets:	CDK \| p21
Source:	The water-extract of Penthorum chinense Pursh
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$30 / 20mg
Download:	COA MSDS
Similar structural:	Comparison

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library p21 Inhibitor Library CDK Inhibitor Library

Description:	2,4,6-Trihydroxybenzoic acid may mediate its effects through a CDK- and SLC5A8-dependent pathway contributing to the prevention of colorectal cancer.
Targets:	CDK \| p21

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.8789 mL	29.3945 mL	58.7889 mL	117.5779 mL	146.9724 mL
5 mM	1.1758 mL	5.8789 mL	11.7578 mL	23.5156 mL	29.3945 mL
10 mM	0.5879 mL	2.9394 mL	5.8789 mL	11.7578 mL	14.6972 mL
50 mM	0.1176 mL	0.5879 mL	1.1758 mL	2.3516 mL	2.9394 mL
100 mM	0.0588 mL	0.2939 mL	0.5879 mL	1.1758 mL	1.4697 mL

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CFN89132	Bellidifolin	2798-25-6	274.22	C₁₄H₁₀O₆
CFN91789	Polygalasaponin II	162857-62-7	959.12	C₄₈H₇₈O₁₉
CFN95059	Lucidumol A	217476-73-8	472.7	C₃₀H₄₈O₄