Science | Nature | Cell | View More
Natural Products
2-Deacetoxytaxinine B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 2-Deacetoxytaxinine B
Price:
CAS No.: 191547-12-3
Catalog No.: CFN99887
Molecular Formula: C35H42O9
Molecular Weight: 606.7 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The barks of Taxus chinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of East Anglia (United Kingdom)
  • University of Bordeaux (France)
  • Universidad de Buenos Aires (Argentina)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Fribourg (Switzerland)
  • Universidade da Beira Interior (Germany)
  • Universidad Miguel Hern├índez (Spain)
  • University of Bonn (Germany)
  • Calcutta University (India)
  • Center for protein Engineering ... (Belgium)
  • Chiang Mai University (Thailand)
  • More...
Package
Featured Products
Berberine hydrochloride

Catalog No: CFN99562
CAS No: 633-65-8
Price: $30/20mg
Polyphyllin D

Catalog No: CFN90255
CAS No: 50773-41-6
Price: $118/20mg
Aloin B

Catalog No: CFN90434
CAS No: 28371-16-6
Price: $138/20mg
Robinin

Catalog No: CFN98375
CAS No: 301-19-9
Price: $318/5mg
Malvidin chloride

Catalog No: CFN92035
CAS No: 643-84-5
Price: $398/10mg
Calceolarioside A

Catalog No: CFN98522
CAS No: 84744-28-5
Price: $ /
Cucurbitacin B

Catalog No: CFN99129
CAS No: 6199-67-3
Price: $70/20mg
Napellonine

Catalog No: CFN90393
CAS No: 509-24-0
Price: $218/20mg
Curcumin

Catalog No: CFN98686
CAS No: 458-37-7
Price: $30/20mg
Alpha-caryophyllene

Catalog No: CFN93582
CAS No: 6753-98-6
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 2-Deacetoxytaxinine B is a strongly inhibitor against U46619-induced aggregation, it shows strong inhibitory effects against arachidonic acid (AA)-induced aggregation.
In vitro:
Thromb Res. 2010 Jun;125(6):e281-4.
A comparative optical aggregometry study of antiplatelet activity of taxanes from Taxus cuspidata.[Pubmed: 20170941]
Platelets are highly reactive components of the circulatory system. The cytoskeleton of a platelet is an important structure for platelet aggregation as stimulated by several agonists. An anticancer agent, taxol, has been suggested to exert platelet anti-aggregating activity by stabilizing microtubules during the aggregation process.
METHODS AND RESULTS:
An activity-guided fractionation was performed with a methanol extract of the leaves and twigs of Taxus cuspidata to isolate taxanes with platelet anti-aggregating effects. Compounds 1 to 7 - taxinine (1), taxinine A (2), taxinine B (3), 2-Deacetoxytaxinine B (4), taxacin (5), taxchinin B (6), and taxol (7) - were obtained as the antiplatelet components of this plant. These taxane compounds present the possibility of securing new antiplatelet compounds which differ from currently available antiplatelet agents in chemical structure and possibly in mechanisms of action.
CONCLUSIONS:
All compounds showed stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA) (IC(50): 14.4, 64.5, 35.5, 16.0, 21.9, 28.6 and 48.2 versus 63.0microM) or U46619 (IC(50): 34.8, 24.9, 36.2, 35.0, 46.9, 71.9 and 68.7 versus 340microM). Compounds 1, 3, 4 and 5, with a cinnamoyl group at the C(5) position, showed strong inhibitory effects against AA-induced aggregation compared to compound 2 (with an -OH group at C(5)) or compounds with an oxetane ring at C(4),(5), such as compounds 6 and 7. All of the seven compounds were 5-13-fold more strongly inhibitory than ASA against U46619-induced aggregation.
2-Deacetoxytaxinine B Description
Source: The barks of Taxus chinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
7-Neohesperidosides

Catalog No: CFN95018
CAS No: 28383-41-7
Price: $288/5mg
trans-Cinnamoyl beta-D-glucoside

Catalog No: CFN95497
CAS No: 13080-39-2
Price: $/mg
Cistantubuloside C1

Catalog No: CFN95121
CAS No: 620632-36-2
Price: $298/10mg
Methylgomisin O

Catalog No: CFN95236
CAS No: N/A
Price: $318/5mg
Neoarctin B

Catalog No: CFN95243
CAS No: 155969-67-8
Price: $318/10mg
8,8''-Bibaicalein

Catalog No: CFN95007
CAS No: 135309-02-3
Price: $318/5mg
Peucenidin

Catalog No: CFN95272
CAS No: 33044-93-8
Price: $318/5mg
Silybin A

Catalog No: CFN95149
CAS No: 22888-70-6
Price: $318/20mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6483 mL 8.2413 mL 16.4826 mL 32.9652 mL 41.2065 mL
5 mM 0.3297 mL 1.6483 mL 3.2965 mL 6.593 mL 8.2413 mL
10 mM 0.1648 mL 0.8241 mL 1.6483 mL 3.2965 mL 4.1207 mL
50 mM 0.033 mL 0.1648 mL 0.3297 mL 0.6593 mL 0.8241 mL
100 mM 0.0165 mL 0.0824 mL 0.1648 mL 0.3297 mL 0.4121 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Berberine hydrochloride

Catalog No: CFN99562
CAS No: 633-65-8
Price: $30/20mg
Polyphyllin D

Catalog No: CFN90255
CAS No: 50773-41-6
Price: $118/20mg
Aloin B

Catalog No: CFN90434
CAS No: 28371-16-6
Price: $138/20mg
Robinin

Catalog No: CFN98375
CAS No: 301-19-9
Price: $318/5mg
Malvidin chloride

Catalog No: CFN92035
CAS No: 643-84-5
Price: $398/10mg
Calceolarioside A

Catalog No: CFN98522
CAS No: 84744-28-5
Price: $ /
Cucurbitacin B

Catalog No: CFN99129
CAS No: 6199-67-3
Price: $70/20mg
Napellonine

Catalog No: CFN90393
CAS No: 509-24-0
Price: $218/20mg
Curcumin

Catalog No: CFN98686
CAS No: 458-37-7
Price: $30/20mg
Alpha-caryophyllene

Catalog No: CFN93582
CAS No: 6753-98-6
Price: $40/20mg
Tags: buy 2-Deacetoxytaxinine B | 2-Deacetoxytaxinine B supplier | purchase 2-Deacetoxytaxinine B | 2-Deacetoxytaxinine B cost | 2-Deacetoxytaxinine B manufacturer | order 2-Deacetoxytaxinine B | 2-Deacetoxytaxinine B distributor