ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Process Biochemistry2019, 85:106-115Toxins (Basel).2020, 12(4):210. Appl. Sci. 2021, 11(22),10569J Ethnopharmacol.2019, 236:31-41Int J Mol Sci.2020, 21(9):3144.Eur J Pharmacol.2022, 917:174744.Sci Rep.2021, 11(1):10931.Pharmaceutics.2022, 14(5):945.
South African J of Botany...2020...Environ Toxicol.2020, doi: 10.1002Evid Based Complement Alternat Me...2021...Appl Biol Chem2019, 62:46J Med Food.2016, 19(12):1155-1165Molecules 2021, 26(4),1092.J Sep Sci.2019, 42(21):3352-3362J of Physics Conference Series...2019...
Molecules.2019, 24(10):E1930Pharmaceutics.2022, 14(3):564.J Korean Society of Food Science ...2021...Comp. & Mathematical Methods in M...2022...J Chromatogr Sci.2015, 53(5):824-9Kasetsart University2022, ethesis.1144.Pharmacol Res.2020, 161:105205.
Our products had been exported to the following research institutions and universities, And still growing.
Johannes Gutenberg University M... (Germany)Pennsylvania State University (USA)Universiti Putra Malaysia(UPM) (Malaysia)Tokyo Woman's Christian University (Japan)
Fraunhofer-Institut für Moleku... (Germany)University of Melbourne (Australia)Sant Gadge Baba Amravati Univer... (India)Universidad de Antioquia (Colombia)
Warszawski Uniwersytet Medyczny (Poland)Universite Libre de Bruxelles (Belgium)The Ohio State University (USA)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Sci Rep.2015, 5:13194J Pharm Biomed Anal2016, 118:183-194Phytother Res.2019, 33(7):1784-1793Biomedicines.2022, 10(5):1170Heliyon2020, 6(6):e04337.Molecules 2022, 27(3),960.Pharmaceutics.2021, 13(7):1028. Biomolecules.2019, 9(11):E696Mol Med Rep.2022, 25(1):8.J Food Biochem.2021, 45(7):e13774.
Related Screening Libraries
||2-Deacetoxytaxinine B is a strongly inhibitor against U46619-induced aggregation, it shows strong inhibitory effects against arachidonic acid (AA)-induced aggregation.|
|Thromb Res. 2010 Jun;125(6):e281-4. |
|A comparative optical aggregometry study of antiplatelet activity of taxanes from Taxus cuspidata.[Pubmed: 20170941]|
|Platelets are highly reactive components of the circulatory system. The cytoskeleton of a platelet is an important structure for platelet aggregation as stimulated by several agonists. An anticancer agent, taxol, has been suggested to exert platelet anti-aggregating activity by stabilizing microtubules during the aggregation process.
METHODS AND RESULTS:
An activity-guided fractionation was performed with a methanol extract of the leaves and twigs of Taxus cuspidata to isolate taxanes with platelet anti-aggregating effects. Compounds 1 to 7 - taxinine (1), taxinine A (2), taxinine B (3), 2-Deacetoxytaxinine B (4), taxacin (5), taxchinin B (6), and taxol (7) - were obtained as the antiplatelet components of this plant. These taxane compounds present the possibility of securing new antiplatelet compounds which differ from currently available antiplatelet agents in chemical structure and possibly in mechanisms of action.
All compounds showed stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA) (IC(50): 14.4, 64.5, 35.5, 16.0, 21.9, 28.6 and 48.2 versus 63.0microM) or U46619 (IC(50): 34.8, 24.9, 36.2, 35.0, 46.9, 71.9 and 68.7 versus 340microM). Compounds 1, 3, 4 and 5, with a cinnamoyl group at the C(5) position, showed strong inhibitory effects against AA-induced aggregation compared to compound 2 (with an -OH group at C(5)) or compounds with an oxetane ring at C(4),(5), such as compounds 6 and 7. All of the seven compounds were 5-13-fold more strongly inhibitory than ASA against U46619-induced aggregation.
2-Deacetoxytaxinine B Description
||The barks of Taxus chinensis
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.