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    Natural Products
    2-Deacetoxytaxinine B
    Information
    CAS No. 191547-12-3 Price
    Catalog No.CFN99887Purity>=98%
    Molecular Weight606.7 Type of CompoundDiterpenoids
    FormulaC35H42O9Physical DescriptionPowder
    Download COA    MSDS    SDF    ManualSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    2-Deacetoxytaxinine B

    2-Deacetoxytaxinine B
    Product Name 2-Deacetoxytaxinine B
    CAS No.: 191547-12-3
    Catalog No.: CFN99887
    Molecular Formula: C35H42O9
    Molecular Weight: 606.7 g/mol
    Purity: >=98%
    Type of Compound: Diterpenoids
    Physical Desc.: Powder
    Source: The barks of Taxus chinensis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Download: COA    MSDS    SDF    Manual
    Similar structural: Comparison (Web)  (SDF)
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  • Sci Rep.2015, 5:13194
  • J Pharm Biomed Anal2016, 118:183-194
  • Phytother Res.2019, 33(7):1784-1793
  • Biomedicines.2022, 10(5):1170
  • Heliyon2020, 6(6):e04337.
  • Molecules 2022, 27(3),960.
  • Pharmaceutics.2021, 13(7):1028.
  • Biomolecules.2019, 9(11):E696
  • Mol Med Rep.2022, 25(1):8.
  • J Food Biochem.2021, 45(7):e13774.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-platelet aggregation Compound Library
  • Diterpenoids Compound Library
  • Biological Activity
    Description: 2-Deacetoxytaxinine B is a strongly inhibitor against U46619-induced aggregation, it shows strong inhibitory effects against arachidonic acid (AA)-induced aggregation.
    In vitro:
    Thromb Res. 2010 Jun;125(6):e281-4.
    A comparative optical aggregometry study of antiplatelet activity of taxanes from Taxus cuspidata.[Pubmed: 20170941]
    Platelets are highly reactive components of the circulatory system. The cytoskeleton of a platelet is an important structure for platelet aggregation as stimulated by several agonists. An anticancer agent, taxol, has been suggested to exert platelet anti-aggregating activity by stabilizing microtubules during the aggregation process.
    METHODS AND RESULTS:
    An activity-guided fractionation was performed with a methanol extract of the leaves and twigs of Taxus cuspidata to isolate taxanes with platelet anti-aggregating effects. Compounds 1 to 7 - taxinine (1), taxinine A (2), taxinine B (3), 2-Deacetoxytaxinine B (4), taxacin (5), taxchinin B (6), and taxol (7) - were obtained as the antiplatelet components of this plant. These taxane compounds present the possibility of securing new antiplatelet compounds which differ from currently available antiplatelet agents in chemical structure and possibly in mechanisms of action.
    CONCLUSIONS:
    All compounds showed stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA) (IC(50): 14.4, 64.5, 35.5, 16.0, 21.9, 28.6 and 48.2 versus 63.0microM) or U46619 (IC(50): 34.8, 24.9, 36.2, 35.0, 46.9, 71.9 and 68.7 versus 340microM). Compounds 1, 3, 4 and 5, with a cinnamoyl group at the C(5) position, showed strong inhibitory effects against AA-induced aggregation compared to compound 2 (with an -OH group at C(5)) or compounds with an oxetane ring at C(4),(5), such as compounds 6 and 7. All of the seven compounds were 5-13-fold more strongly inhibitory than ASA against U46619-induced aggregation.
    2-Deacetoxytaxinine B Description
    Source: The barks of Taxus chinensis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6483 mL 8.2413 mL 16.4826 mL 32.9652 mL 41.2065 mL
    5 mM 0.3297 mL 1.6483 mL 3.2965 mL 6.593 mL 8.2413 mL
    10 mM 0.1648 mL 0.8241 mL 1.6483 mL 3.2965 mL 4.1207 mL
    50 mM 0.033 mL 0.1648 mL 0.3297 mL 0.6593 mL 0.8241 mL
    100 mM 0.0165 mL 0.0824 mL 0.1648 mL 0.3297 mL 0.4121 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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