Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    3,5-Dicaffeoyl-epi-quinic acid
    Information
    CAS No. 879305-14-3 Price
    Catalog No.CFN91944Purity>=98%
    Molecular Weight516.45Type of CompoundPhenylpropanoids
    FormulaC25H24O12Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Universit?t Basel (Switzerland)
  • Institute of Bioorganic Chemist... (Poland)
  • University of Malaya (Malaysia)
  • University of Vienna (Austria)
  • Sant Gadge Baba Amravati Univer... (India)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Complutense University of Madrid (Spain)
  • Mahidol University (Thailand)
  • China Medical University (Taiwan)
  • Biotech R&D Institute (USA)
  • Charles Sturt University (Denmark)
  • More...
  • Package
    Featured Products
    3,6'-Disinapoyl sucrose

    Catalog No: CFN90578
    CAS No: 139891-98-8
    Price: $138/20mg
    Angustifoline

    Catalog No: CFN92233
    CAS No: 550-43-6
    Price: $490/5mg
    Glychionide A

    Catalog No: CFN92280
    CAS No: 119152-50-0
    Price: $318/5mg
    Platycoside M1

    Catalog No: CFN92267
    CAS No: 917482-67-8
    Price: $468/5mg
    Febrifugine

    Catalog No: CFN92302
    CAS No: 24159-07-7
    Price: $388/20mg
    Neochlorogenic acid

    Catalog No: CFN97472
    CAS No: 906-33-2
    Price: $118/20mg
    Astragalin

    Catalog No: CFN98733
    CAS No: 480-10-4
    Price: $138/20mg

    3,5-Dicaffeoyl-epi-quinic acid

    3,5-Dicaffeoyl-epi-quinic acid
    Product Name 3,5-Dicaffeoyl-epi-quinic acid
    CAS No.: 879305-14-3
    Catalog No.: CFN91944
    Molecular Formula: C25H24O12
    Molecular Weight: 516.45 g/mol
    Purity: >=98%
    Type of Compound: Phenylpropanoids
    Physical Desc.: Powder
    Targets: TNF-伪 | IL Receptor | JNK | Caspase | p38MAPK | Histamine Receptor
    Source: The herbs of Lonicera japonica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Enzyme Microb Technol.2019, 122:64-73
  • Clin Transl Oncol.2019, 10.1007
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • Org Biomol Chem.2017, 15(31):6483-6492
  • BMC Complement Med Ther. 2020, 20(1):94.
  • Foods.2020, 9(10):1348.
  • Food and Chemical Toxicology2020, 111221
  • Drug Test Anal.2018, 10(10):1579-1589
  • Anat Rec2018, 24264
  • Food Chem.2019, 279:80-87
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Phenylpropanoids Compound Library
  • TNF-α Inhibitor Library
  • p38MAPK Inhibitor Library
  • JNK Inhibitor Library
  • IL Receptor Inhibitor Library
  • Histamine Receptor Inhibitor Library
  • Caspase Inhibitor Library
  • Biological Activity
    Description: 3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
    Targets: TNF-α | IL Receptor | JNK | Caspase | p38MAPK | Histamine Receptor
    In vitro:
    Immunopharmacol Immunotoxicol. 2018 Feb;40(1):52-58.
    Anti-inflammatory effects of Artemisia scoparia and its active constituent, 3,5-dicaffeoyl-epi-quinic acid against activated mast cells.[Pubmed: 29172841 ]
    Artemisia scoparia Waldst. et Kit. (AS) has been used to treat inflammation, urticaria and hepatitis. However, the scientific studies of AS and its active compound for inflammatory reactions in activated human mast cell line, HMC-1 cells have not yet been elucidated.
    METHODS AND RESULTS:
    Here, we isolated 3,5-Dicaffeoyl-epi-quinic acid (DEQA) from AS butanol fraction. The anti-inflammatory effect of AS and its new active compound, DEQA was examined in HMC-1 cells by studying the following markers: phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced thymic stromal lymphopoietin (TSLP), tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 secretion and mRNA expression by ELISA and RT-PCR, respectively. Furthermore, mechanism related to anti-inflammatory was examined by Western blotting. We reported that AS and its new active compound, DEQA significantly reduced TSLP, TNF-α, IL-1β and IL-6 production levels through the reduction of caspase-1 activity. The mRNA expression of these inflammatory cytokine was also reduced via blocking nuclear factor-κB nuclear translocation by AS and DEQA. In addition, AS significantly reduced phosphorylated-c-Jun N-terminal kinase level and DEQA significantly reduced both phosphorylated-c-Jun N-terminal kinase and -p38 mitogen-activated protein kinase levels.
    CONCLUSIONS:
    Therefore, these results indicated that AS and its active compound, DEQA may improve mast cell-mediated inflammatory diseases.
    In vivo:
    Clin Exp Dermatol. 2018 May 8.
    Therapeutic effects of Artemisia scoparia Waldst. et Kitaib in a murine model of atopic dermatitis.[Pubmed: 29740850 ]
    Artemisia scoparia Waldst. et Kitaib (AS) (Oriental wormwood, known as Bissuk in Korea) is a plant used in cosmetic and pharmaceutical treatments. However, the effect of AS on atopic dermatitis (AD) has not been described. To examine the inhibitory effect of AS on AD using a murine model.
    METHODS AND RESULTS:
    We applied either AS, the butanol-extracted fraction of AS (Bu-OH) or 3,5-Dicaffeoyl-epi-quinic acid (DEQA, a major component of Bu-OH) topically for 3 weeks to 2,4-dinitrofluorobenzene (DNFB)-induced skin lesions in BALB/c mice. AS, Bu-OH and DEQA suppressed the clinical symptoms of DNFB-induced skin lesions and he associated scratching behaviour. Numbers of inflammatory cells infiltrating skin lesions were significantly reduced by AS or Bu-OH application but not by DEQA. In addition, AS significantly suppressed serum levels of histamine and IgE, while Bu-OH significantly suppressed serum levels of histamine, IgE, thymic stromal lymphopoietin (TSLP), interleukin (IL)-4 and IL-6, and DEQA significantly suppressed serum levels of histamine, IgE, TSLP and IL-4 in DNFB-induced AD mice. In skin lesions, AS and Bu-OH significantly reduced inflammatory cytokines, whereas DEQA did not. AS, Bu-OH and DEQA all significantly suppressed caspase-1 activities.
    CONCLUSIONS:
    These results demonstrate the anti-AD effects of AS, Bu-OH and DEQA, and suggest that all three have therapeutic potential.
    3,5-Dicaffeoyl-epi-quinic acid Description
    Source: The herbs of Lonicera japonica
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    (3E,5E,11E)-tridecatriene-7,9-diyn...

    Catalog No: CFN95191
    CAS No: N/A
    Price: $318/5mg
    Selina-4(15),7(11)-dien-8-one

    Catalog No: CFN95078
    CAS No: 54707-47-0
    Price: $288/10mg
    Silychristin B

    Catalog No: CFN95160
    CAS No: 879325-58-3
    Price: $318/5mg
    Parishin G

    Catalog No: CFN95324
    CAS No: 952283-93-1
    Price: $318/10mg
    Gynosaponin TN2

    Catalog No: CFN95331
    CAS No: 77658-95-8
    Price: $318/5mg
    Euphorbia factor L25

    Catalog No: CFN95339
    CAS No: 303174-98-3
    Price: $368/5mg
    3,4-O-dimethylcedrusin

    Catalog No: CFN95026
    CAS No: 166021-14-3
    Price: $388/10mg
    (1E)-3-methoxy-8,12-epoxygermacra-...

    Catalog No: CFN95219
    CAS No: 1393342-06-7
    Price: $413/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9363 mL 9.6815 mL 19.363 mL 38.7259 mL 48.4074 mL
    5 mM 0.3873 mL 1.9363 mL 3.8726 mL 7.7452 mL 9.6815 mL
    10 mM 0.1936 mL 0.9681 mL 1.9363 mL 3.8726 mL 4.8407 mL
    50 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.7745 mL 0.9681 mL
    100 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.3873 mL 0.4841 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    3,6'-Disinapoyl sucrose

    Catalog No: CFN90578
    CAS No: 139891-98-8
    Price: $138/20mg
    Angustifoline

    Catalog No: CFN92233
    CAS No: 550-43-6
    Price: $490/5mg
    Glychionide A

    Catalog No: CFN92280
    CAS No: 119152-50-0
    Price: $318/5mg
    Platycoside M1

    Catalog No: CFN92267
    CAS No: 917482-67-8
    Price: $468/5mg
    Febrifugine

    Catalog No: CFN92302
    CAS No: 24159-07-7
    Price: $388/20mg
    Neochlorogenic acid

    Catalog No: CFN97472
    CAS No: 906-33-2
    Price: $118/20mg
    Astragalin

    Catalog No: CFN98733
    CAS No: 480-10-4
    Price: $138/20mg