Canadine | CAS:5096-57-1 | Manufacturer ChemFaces

Canadine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Canadine has antioxidant activity with low-toxic effect.

Targets:

P450 (e.g. CYP17)

In vitro:

Bioorg Med Chem. 2008 Apr 1;16(7):3641-51.

Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects.[Pubmed: 18295494]

METHODS AND RESULTS:
The cytotoxic effects of four alkaloids, berberine, Canadine, anonaine, and antioquine were evaluated using three different cell cultures, a primary culture (rat hepatocytes) and two cell lines (HepG2 and HeLa). Our results indicate that berberine, anonaine, and antioquine possess a significant the cytotoxic effect. In contrast, Canadine does not possess cytotoxic effect at concentrations tested here. A molecular modeling study indicates that the quaternary nitrogen, the aromatic polycyclic and planar structure of berberine could be the pharmacophoric patron to produce the cytotoxic effect. In parallel our results demonstrated that Canadine possess a significant antioxidant activity. Stereoelectronic aspects of this alkaloid were found to be closely related to those displayed by alpha-tocopherol and its water-soluble analogue trolox.
CONCLUSIONS:
The antioxidant activities of Canadine, combined with its low-toxic effect, indicated that the potential of this alkaloid as a novel class of antioxidant agent is very interesting and deserves further research.

Canadine Description

Source:	The bulbs of Corydalis yanhusuo
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

FEBS Lett. 2014 Jan 3;588(1):198-204.

Cloning and characterization of canadine synthase involved in noscapine biosynthesis in opium poppy.[Pubmed: 24316226]

Noscapine biosynthesis in opium poppy is thought to occur via N-methylCanadine, which would be produced through 9-O-methylation of (S)-scoulerine, methylenedioxy bridge formation on (S)-tetrahydrocolumbamine, and N-methylation of (S)-Canadine. Only scoulerine 9-O-methyltransferase has been functionally characterized.
METHODS AND RESULTS:
We report the isolation and characterization of a cytochrome P450 (CYP719A21) from opium poppy that converts (S)-tetrahydrocolumbamine to (S)-Canadine. Recombinant CYP719A21 displayed strict substrate specificity and high affinity (Km=4.63±0.71 μM) for (S)-tetrahydrocolumbamine. Virus-induced gene silencing of CYP719A21 caused a significant increase in (S)-tetrahydrocolumbamine accumulation and a corresponding decrease in the levels of putative downstream intermediates and noscapine in opium poppy plants.

Product Name	Canadine
Price:
CAS No.:	5096-57-1
Catalog No.:	CFN98810
Molecular Formula:	C₂₀H₂₁NO₄
Molecular Weight:	339.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The bulbs of Corydalis yanhusuo
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Alkaloids Compound Library P450 (e.g. CYP17) Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9464 mL	14.7319 mL	29.4638 mL	58.9275 mL	73.6594 mL
5 mM	0.5893 mL	2.9464 mL	5.8928 mL	11.7855 mL	14.7319 mL
10 mM	0.2946 mL	1.4732 mL	2.9464 mL	5.8928 mL	7.3659 mL
50 mM	0.0589 mL	0.2946 mL	0.5893 mL	1.1786 mL	1.4732 mL
100 mM	0.0295 mL	0.1473 mL	0.2946 mL	0.5893 mL	0.7366 mL

CFN90188	D-Tetrahydropalmatine	3520-14-7	355.41	C₂₁H₂₅NO₄
CFN90416	Tetrahydrocoptisine	7461-02-1	323.12	C₁₉H₁₇NO₄
CFN96656	Stylopine hydrochloride	96087-21-7	359.81	C₁₉H₁₈ClNO₄
CFN90457	L-Stepholidine	16562-13-3	327.37	C₁₉H₂₁NO₄
CFN96330	Scoulerine	6451-73-6	327.4	C₁₉H₂₁NO₄
CFN90506	Tetrahydroberberine	522-97-4	339.38	C₂₀H₂₁O₄N
CFN90945	Cheilanthifoline	483-44-3	325.36	C₁₉H₁₉NO₄
CFN90507	Tetrahydroepiberberine	38853-67-7	339.15	C₂₀H₂₁NO₄
CFN97021	Corypalmine	6018-40-2	341.4	C₂₀H₂₃NO₄
CFN90582	(-)-Isocorypalmine	483-34-1	341.4	C₂₀H₂₃NO₄