ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Clematomandshurica saponin B
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $1,188.3 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
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Clematomandshurica saponin B
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manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
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Fax:
+86-27-84254680
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Phytomedicine.2018, 41:62-66Biochemistry.2018, 57(40):5886-5896Evid Based Complement Alternat Med.2016, 2016:4357656Aquaculture2019, 510:392-399J Sci Food Agric.2017, 97(5):1656-1662Plant Sci.2020, 301:110656.FASEB J.2019, 33(2):2026-2036Molecules2021, 26(1),230Mol Cell.2017, 68(4):673-685Biol Pharm Bull.2018, 41(11):1685-1693
Related Screening Libraries
| Description: |
Clematomandshurica saponin B shows significant inhibitory activity on cyclooxygenase-2 (IC50 = 2.58 microM). |
| Targets: |
COX-2 |
Clematomandshurica saponin B Description
| Source: |
The roots and rhizomes of Clematis mandshurica. |
| Solvent: |
DMSO, Pyridine, Methanol, Ethanol, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
0.504 mL |
2.52 mL |
5.0401 mL |
10.0801 mL |
12.6002 mL |
| 5 mM |
0.1008 mL |
0.504 mL |
1.008 mL |
2.016 mL |
2.52 mL |
| 10 mM |
0.0504 mL |
0.252 mL |
0.504 mL |
1.008 mL |
1.26 mL |
| 50 mM |
0.0101 mL |
0.0504 mL |
0.1008 mL |
0.2016 mL |
0.252 mL |
| 100 mM |
0.005 mL |
0.0252 mL |
0.0504 mL |
0.1008 mL |
0.126 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| J Nat Prod. 2006 Nov;69(11):1591-5. | | Triterpene saponins from clematis mandshurica.[Pubmed: 17125227 ] |
METHODS AND RESULTS:
Four new triterpene saponins, clematomandshurica saponin A, Clematomandshurica saponin B,clematomandshurica saponin C, clematomandshurica saponin D (1-4), together with three known saponins (5-7) have been isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of their spectroscopic evidence and hydrolysis.
CONCLUSIONS:
Clematomandshurica saponin A and Clematomandshurica saponin B showed significant inhibitory activity on cyclooxygenase-2 (IC50 = 2.66 and 2.58 microM, respectively). |
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