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Cleomiscosin C
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Product Name Cleomiscosin C
Price:
CAS No.: 84575-10-0
Catalog No.: CFN97400
Molecular Formula: C21H20O9
Molecular Weight: 416.4 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The herbs of Buxus sinica.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cleomiscosin C has antioxidant activity, it protects against the oxidative modification of apoB-100 induced by either Cu2+ or HOCl ( IC50s of 23.6 and 3.9 microM, respectively), suggests that it could be beneficial in preventing LDL oxidation in atherosclerotic lesions. Cleomiscosins A, B and C exhibit liver-protective properties.
Targets: SOD | LDL
In vitro:
Arch Pharm Res. 2007 Mar;30(3):275-81.
Antioxidant activity of cleomiscosins A and C isolated from Acer okamotoanum.[Pubmed: 17424931]
Phytochemical investigation of Acer okamotoanum leaf and twig led to the isolation of two coumarinolignans, cleomiscosin A (1) and Cleomiscosin C (2).
METHODS AND RESULTS:
Here, we found that 2 dose-dependently inhibits LDL oxidation mediated by either catalytic copper ions (Cu2+) or free radicals generated with the azo compound 2,2'-azobis-(2-amidinopropane)dihydro-chloride (AAPH) with IC50s of 29.5 and 11.9 microM, respectively. By electrophoretic analysis, we also observed that Cleomiscosin C protects apolipoprotein B-100 (apoB-100) against Cu2+-induced fragmentation (65.3% inhibition at 5 microM). Furthermore, fluorescence analyses clearly indicated that both 1 and 2 protect against the oxidative modification of apoB-100 induced by either Cu2+ or HOCl (1, IC50s of 13.4 and 8.1 microM, respectively; 2, IC50s of 23.6 and 3.9 microM, respectively).
CONCLUSIONS:
These findings suggest that 1 and Cleomiscosin C could be beneficial in preventing LDL oxidation in atherosclerotic lesions.
Cleomiscosin C Description
Source: The herbs of Buxus sinica.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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PMID: 32004475

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doi: 10.1016/j.molcel.2017.10.022.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4015 mL 12.0077 mL 24.0154 mL 48.0307 mL 60.0384 mL
5 mM 0.4803 mL 2.4015 mL 4.8031 mL 9.6061 mL 12.0077 mL
10 mM 0.2402 mL 1.2008 mL 2.4015 mL 4.8031 mL 6.0038 mL
50 mM 0.048 mL 0.2402 mL 0.4803 mL 0.9606 mL 1.2008 mL
100 mM 0.024 mL 0.1201 mL 0.2402 mL 0.4803 mL 0.6004 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Med. 2011 Jan;65(1):191-3.
Aromatic compounds and their antioxidant activity of Acer saccharum.[Pubmed: 20686865]

METHODS AND RESULTS:
A new lignan glycoside, 5-(3″,4″-dimethoxy-phenyl)-3-hydroxy-3-(4'-hydroxy-3'-methoxybenzyl)-4-hydroxymethyl-dihydrofuran-2-one 4'-O-α-L: -rhamnopyranoside (1), with seven known compounds, compound 2, koaburside, icariside E(4), Cleomiscosin C, cleomiscosin D, scopoletin, and 5'-demethylaquillochin, were isolated from the EtOH extract of the wood of Acer saccharum (Aceraceae). Their structures were determined by 1D and 2D nuclear magnetic resonance (NMR) and mass spectroscopy analysis. All of the isolated compounds, 1-8, were tested for their antioxidant activity in superoxide dismutase (SOD)-like assay.
Tetrahedron, 1985, 41(1):209-14.
Structures of cleomiscosins, coumarinolignoids of cleome viscosa seeds.[Reference: WebLink]

METHODS AND RESULTS:
Structures of cleomiscosin A, cleomiscosin B and Cleomiscosin C, three new coumarino-lignoids isolated from the seeds of Cleome viscosa Linné, have been established as 1a, 2a and 1f irrespectively, on the basis of spectral and chemical evidence.
CONCLUSIONS:
The compounds exhibited liver-protective properties.
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