| In vitro: |
| J Nat Prod. 2007 Jul;70(7):1207-9. | | Prenylated xanthones from the root bark of Cudrania tricuspidata.[Pubmed: 17608532] |
METHODS AND RESULTS:
Four new prenylated xanthones, cudratricusxanthones J-M (1-4), were isolated from the CH2Cl2-soluble extract of the root bark of Cudrania tricuspidata, along with four known prenylated xanthones, isocudraxanthone K (5), cudraxanthone C (6), cudratricusxanthone A (7), and Cudraxanthone L (8), and three known prenylated flavonoids, cudraflavone A (9), cudraflavanone A (10), and cudraflavone B (11).
CONCLUSIONS:
The structures of compounds 1-4 were elucidated using spectroscopic methods. Cudratricusxanthone A (7), cudraflavanone A (10), and cudraflavone B (11) showed moderate inhibitory effects on mouse brain monoamine oxidase (MAO) with IC50 values of 88.3, 89.7, and 80.0 microM, respectively. | | Arch Pharm Res. 2005 Jan;28(1):44-8. | | Hepatoprotective constituents of Cudrania tricuspidata.[Pubmed: 15742807] |
METHODS AND RESULTS:
Phytochemical investigation of the MeOH extract of the root barks of Cudrania tricuspidata Bureau (Moraceae), as guided by hepatoprotective activity in vitro, furnished four isoprenylated xanthones, cudratricusxanthone A (1), Cudraxanthone L (2), cudratricusxanthone E (3), and macluraxanthone B (4).
CONCLUSIONS:
All of these compounds showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Compounds 1, 2, and 4 also exhibited the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells. |
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