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    Natural Products
    Dioscoreside C
    Dioscoreside C
    Information
    CAS No. 344912-80-7 Price $318 / 5mg
    Catalog No.CFN95345Purity>=98%
    Molecular Weight1061.2Type of CompoundSteroids
    FormulaC52H84O22Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $598.2 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Dioscoreside C

    Dioscoreside C
    Product Name Dioscoreside C
    CAS No.: 344912-80-7
    Catalog No.: CFN95345
    Molecular Formula: C52H84O22
    Molecular Weight: 1061.2 g/mol
    Purity: >=98%
    Type of Compound: Steroids
    Physical Desc.: Powder
    Source: The rhizomes of Dioscorea panthaica
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $318 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Yakugaku Zasshi.2018, 138(4):571-579
  • Exp Ther Med.2019, 18(6):4388-4396
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • Life Sci.2018, 209:498-506
  • Sci Rep.2018, 8(1):12970
  • J Sci Food Agric.2018, 98(3):1153-1161
  • Acta Agriculturae Scandinavica2015, 381-383
  • Current Pharmaceutical Analysis2017, 13(5)
  • Molecules.2018, 23(2)
  • PLoS One.2018, 13(11):e0208055
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Cytotoxic Compound Library
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  • Biological Activity
    Description: Dioscoreside C showed mild cytotoxicity against the cancer cell lines, A375, L929, and HeLa, in a dose-dependent manner.
    In vitro:
    Planta Med . 2001 Dec;67(9):853-7
    Two new steroidal saponins from the rhizomes of Dioscorea panthaica and their cytotoxic activity[Pubmed: 11745024]
    Two new steroidal saponins, dioscoresides C (1) and D (2), along with a new natural product, pregnadienolone 3-O-beta-gracillimatriose (3), and two known compounds, pregnadienolone 3-O-beta-chacotrioside (4) and pseudoprotodioscin (5), were isolated from the rhizomes of Dioscorea panthaica Prain et Burkill. On the basis of extensive NMR studies and chemical evidence, dioscoresides C and D were determined to be 26-O-beta-D-glucopyranosyl-3 beta,26-dihydroxy-23(S)-methoxy-25(R)-furosta-5,20(22)-dien-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucopyranoside and 26-O-beta-D-glucopyranosyl-3 beta,26-dihydroxy-20,22-seco-25(R)-furosta-5-en-20,22-dine-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1--> 4)]-beta-D-glucopyranoside. These compounds showed mild cytotoxicity against the cancer cell lines, A375, L929, and HeLa, in a dose-dependent manner.
    Dioscoreside C Description
    Source: The rhizomes of Dioscorea panthaica
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9423 mL 4.7116 mL 9.4233 mL 18.8466 mL 23.5582 mL
    5 mM 0.1885 mL 0.9423 mL 1.8847 mL 3.7693 mL 4.7116 mL
    10 mM 0.0942 mL 0.4712 mL 0.9423 mL 1.8847 mL 2.3558 mL
    50 mM 0.0188 mL 0.0942 mL 0.1885 mL 0.3769 mL 0.4712 mL
    100 mM 0.0094 mL 0.0471 mL 0.0942 mL 0.1885 mL 0.2356 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Isolation and identification of steroidal saponins from Dioscorea panthaica Prain et Burkill
    Yao Xue Xue Bao . 2001 Jan;36(1):42-5.[Pubmed: 12579859]
    Aim: To investigate the chemical constituents of the rhizomes of Dioscorea panthaica Prain et Burkill and look for new active compounds. Methods: The compounds were isolated with silica gel and HPLC, and their structures were elucidated on the basis of chemical evidences and spectral analysis (IR, ESI-MS, 1HNMR, 13CNMR, DEPT, 1H-1H COSY, HMQC, HMBC, NOESY). Results: Three steroidal saponins were isolated from the rhizomes of Dioscorea panthaica. They were elucidated as 26-O-beta-D-glucopyranosyl-3 beta, 26-diol-23(S)-methoxy-25(R)-delta 5,20(22)-diene-furosta-3-O-[alpha-L-rhamnopyranosyl-(1-->2)- O-alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucopyranoside (I), pseudoprotodioscin (II), 26-O-beta-D-glucopyranosyl-3 beta, 26-diol-25 (R)-delta 5,20(22)-diene-furosta-3-O-alpha-L-rhamnopyranosyl- (1-->2)-O-beta-D-glucopyranoside (III). Conclusion: Compound I is a new steroidal saponin and was named as Dioscoreside C. Compound II and III were obtained from this genus for the first time.
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