Pinosylvin monomethyl ether | CAS:35302-70-6

Pinosylvin monomethyl ether

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Description:

Pinosylvin monomethyl ether (E)-3-Hydroxy-5-methoxystilbene possesses inhibitory activity against several Gram-positive bacteria, including isolates of methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium bovis BCG, and avirulent Bacillusanthracis (Sterne strain), among others.

Targets:

Antifection

In vitro:

Bioorg Med Chem Lett. 2008 Nov 1;18(21):5745-9.

New classes of Gram-positive selective antibacterials: inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis.[Pubmed: 18849164]

METHODS AND RESULTS:
An antimicrobial phenolic stilbene, (E)-3-Hydroxy-5-methoxystilbene, 1 was recently isolated from the leaves of Comptonia peregrina (L.) Coulter and shown to possess inhibitory activity against several Gram-positive bacteria, including isolates of methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium bovis BCG, and avirulent Bacillusanthracis (Sterne strain), among others. These results prompted the design and synthesis of two new classes of compounds, phenoxystyrenes and phenothiostyrenes, as analogs of the natural antimicrobial stilbene. These and additional stilbenoid analogs were synthesized using new, efficient, copper-mediated coupling strategies. Minimum inhibitory concentration (MIC) antimicrobial assays were performed on all compounds prepared.
CONCLUSIONS:
These preliminary structure-activity relationship studies indicated that both new classes of synthetic analogs, as well as the stilbenes, show promising activity against Gram-positive bacteria when at least one phenolic moiety is present, but not when absent. The potencies of the phenolic phenoxystyrenes and phenothiostyrenes were found to be comparable to those of the phenolic stilbenes tested.

Pinosylvin monomethyl ether Description

Source:	The herbs of Jatropha curcas
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Pinosylvin monomethyl ether
Price:	$318 / 10mg
CAS No.:	35302-70-6
Catalog No.:	CFN98466
Molecular Formula:	C₁₅H₁₄O₂
Molecular Weight:	226.3 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Jatropha curcas
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Phenols Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.4189 mL	22.0946 mL	44.1891 mL	88.3783 mL	110.4728 mL
5 mM	0.8838 mL	4.4189 mL	8.8378 mL	17.6757 mL	22.0946 mL
10 mM	0.4419 mL	2.2095 mL	4.4189 mL	8.8378 mL	11.0473 mL
50 mM	0.0884 mL	0.4419 mL	0.8838 mL	1.7676 mL	2.2095 mL
100 mM	0.0442 mL	0.2209 mL	0.4419 mL	0.8838 mL	1.1047 mL

CFN99500	Dihydropinosylvin	14531-52-3	214.3	C₁₄H₁₄O₂
CFN98203	Pinosylvin	22139-77-1	212.3	C₁₄H₁₂O₂
CFN99829	Dihydropinosylvin methyl ether	17635-59-5	228.3	C₁₅H₁₆O₂
CFN98466	Pinosylvin monomethyl ether	35302-70-6	226.3	C₁₅H₁₄O₂
CFN97200	(E)-3-Acetoxy-5-methoxystilbene	71144-78-0	268.3	C₁₇H₁₆O₃
CFN92586	Trans-Pinosylvin dimethyl ether	21956-56-9	240.3	C₁₆H₁₆O₂
CFN97810	Stilbostemin B	162411-67-8	228.29	C₁₅H₁₆O₂
CFN95448	Cajanine	87402-84-4	338.4	C₂₁H₂₂O₄