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Gnemonol B
Gnemonol B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Gnemonol B
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CAS No.: 462636-74-4
Catalog No.: CFN92442
Molecular Formula: C56H42O12
Molecular Weight: 907.0 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The herbs of Gnetum montanum
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Gnemonol B exhibits strong antibacterial activity against vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA).
Targets: Antifection
Gnemonol B Description
Source: The herbs of Gnetum montanum
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.1025 mL 5.5127 mL 11.0254 mL 22.0507 mL 27.5634 mL
5 mM 0.2205 mL 1.1025 mL 2.2051 mL 4.4101 mL 5.5127 mL
10 mM 0.1103 mL 0.5513 mL 1.1025 mL 2.2051 mL 2.7563 mL
50 mM 0.0221 mL 0.1103 mL 0.2205 mL 0.441 mL 0.5513 mL
100 mM 0.011 mL 0.0551 mL 0.1103 mL 0.2205 mL 0.2756 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Biocontrol Sci. 2007 Mar;12(1):7-14.
Antibacterial activity of stilbene oligomers against vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) and their synergism with antibiotics.[Pubmed: 17408003]

METHODS AND RESULTS:
Two resveratrol trimers, Gnemonol B isolated from Gnetum gnemon and gnetin E obtained from the Gnetum species, were found to exhibit strong antibacterial activities against vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). The MIC values of Gnemonol B against five strains of VRE and nine strains of MRSA were 12.5 and 6.25 microg/ml, respectively. The MIC values of gnetin E against five strains of VRE and nine strains of MRSA ranged from 12.5 to 25microg/ml. These compounds also showed synergistic effects when used in combination with commercially available antibiotics according to the evaluation method using FIC indices.
CONCLUSIONS:
These findings suggested that the application of the test compounds alone or in combination with antibiotics might be useful in controlling and treating VRE and MRSA infections.
CFN95093Caraganaphenol A174916-31-5923.0C56H42O13
CFN92530Kobophenol A124027-58-3925.0C56H44O13
CFN95042Carasinol B777857-86-0925.0C56H44O13
CFN93787(-)-Ampelopsin HN/A907.0C56H42O12
CFN97068alpha-Viniferin62218-13-7678.7 C42H30O9
CFN98469Caraphenol A354553-35-8676.7 C42H28O9
CFN97082Viniferol D625096-18-6680.7 C42H32O9
CFN96132Mulberrofuran C77996-04-4580.6C34H28O9
CFN92788Mulberrofuran G87085-00-5562.6C34H26O8
CFN96253Mulberrofuran G pentaacetate99217-75-1772.8C44H36O13
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