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    Humulene epoxide II
    Information
    CAS No. 19888-34-7 Price
    Catalog No.CFN98008Purity>=98%
    Molecular Weight220.4 Type of CompoundSesquiterpenoids
    FormulaC15H24OPhysical DescriptionSolid
    Download COA    MSDS    SDF    ManualSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Humulene epoxide II

    Humulene epoxide II
    Product Name Humulene epoxide II
    CAS No.: 19888-34-7
    Catalog No.: CFN98008
    Molecular Formula: C15H24O
    Molecular Weight: 220.4 g/mol
    Purity: >=98%
    Type of Compound: Sesquiterpenoids
    Physical Desc.: Solid
    Targets: Antifection
    Source: The rhizomes of Zingiber officinale Roscoe
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Download: COA    MSDS    SDF    Manual
    Similar structural: Comparison (Web)  (SDF)
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  • Evid Based Complement Alternat Med.2020, 2020:8582318.
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antimalaric Compound Library
  • Sesquiterpenoids Compound Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Humulene epoxide II has antimalarial activity.
    Targets: Antifection
    In vitro:
    Nat Prod Res. 2015;29(9):883-6.
    Composition and antioxidant activity of Senecio nudicaulis Wall. ex DC. (Asteraceae): a medicinal plant growing wild in Himachal Pradesh, India.[Pubmed: 25515495]

    METHODS AND RESULTS:
    The composition of essential oil isolated from Senecio nudicaulis Wall. ex DC. growing wild in Himachal Pradesh, India, was analysed, for the first time, by capillary gas chromatography (GC) and GC-mass spectrometry. A total of 30 components representing 95.3% of the total oil were identified. The essential oil was characterised by a high content of oxygenated sesquiterpenes (54.97%) with caryophyllene oxide (24.99%) as the major component. Other significant constituents were Humulene epoxide II (21.25%), α-humulene (18.75%), β-caryophyllene (9.67%), epi-α-cadinol (2.90%), epi-α-muurolol (2.03%), β-cedrene (1.76%), longiborneol (1.76%), 1-tridecene (1.16%) and citronellol (1.13%). The oil was screened for antioxidant activity using DPPH, ABTS and nitric oxide-scavenging assay.
    CONCLUSIONS:
    The oil was found to exhibit significant antioxidant activity by scavenging DPPH, ABTS and nitric oxide radicals with IC50 values of 10.61 ± 0.14 μg mL(- 1), 11.85 ± 0.28 μg mL(- 1) and 11.29 ± 0.42 μg mL(- 1), respectively.
    Molecules. 2015 May 4;20(5):7990-9.
    Chemical Composition and Insecticidal Activity of Essential Oils from Zanthoxylum dissitum Leaves and Roots against Three Species of Storage Pests.[Pubmed: 25946557]
    This work aimed to investigate chemical composition of essential oils obtained from Zanthoxylum dissitum leaves and roots and their insecticidal activities against several stored product pests, namely the cigarette beetle (Lasioderma serricorne), red flour beetle (Tribolium castaneum) and black carpet beetle (Attagenus piceus).
    METHODS AND RESULTS:
    The analysis by GC-MS of the essential oils allowed the identification of 28 and 22 components, respectively. It was found that sesquiterpenoids comprised a fairly high portion of the two essential oils, with percentages of 74.0% and 80.9% in the leaves and roots, respectively. The main constituents identified in the essential oil of Z. dissitum leaves were δ-cadinol (12.8%), caryophyllene (12.7%), β-cubebene (7.9%), 4-terpineol (7.5%) and germacrene D-4-ol (5.7%), while Humulene epoxide II (29.4%), caryophyllene oxide (24.0%), diepicedrene-1-oxide (10.7%) and Z,Z,Z-1,5,9,9-tetramethyl-1,4,7-cycloundecatriene (8.7%) were the major components in the essential oil of Z. dissitum roots.
    CONCLUSIONS:
    The insecticidal activity results indicated that the essential oil of Z. dissitum roots exhibited moderate contact toxicity against three species of storage pests, L. serricorne,T. castaneum and A. piceus, with LD50 values of 13.8, 43.7 and 96.8 µg/adult, respectively.
    Humulene epoxide II Description
    Source: The rhizomes of Zingiber officinale Roscoe
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.5372 mL 22.686 mL 45.3721 mL 90.7441 mL 113.4301 mL
    5 mM 0.9074 mL 4.5372 mL 9.0744 mL 18.1488 mL 22.686 mL
    10 mM 0.4537 mL 2.2686 mL 4.5372 mL 9.0744 mL 11.343 mL
    50 mM 0.0907 mL 0.4537 mL 0.9074 mL 1.8149 mL 2.2686 mL
    100 mM 0.0454 mL 0.2269 mL 0.4537 mL 0.9074 mL 1.1343 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Pharm. Biol., 2004, 42(2):94-7.
    Chemical Constituents and Preliminary Antimalarial Activity of Humiria balsamifera.[Reference: WebLink]

    METHODS AND RESULTS:
    From stems and leaves of Humiria balsamifera St. (Aubl.) Hill (Humiriaceae) were isolated 6 triterpenes [arjunolic acid, 2β,3α-dihydroxy-D:A-friedooleanane, friedelin, α- and β-amyrins and lupeol], a flavonol (quercetin), an isocoumarin (bergenin) a diterpene (phytol), and 2 phytosteroids (sitosterol and stigmasterol)]. Three sesquiterpenoids [caryophyllene oxide (0.9%), Humulene epoxide II (0.3%) and trans-isolongifolenone (0.6%)], a diterpene [phytol (29.4%)] and four aliphatic esters [methyl tetra- (0.3%), hexa- (26.6%) and octadecanoate (0.3%), and ethyl tetradecanoate (26.9%)] were identified by GC/MS. Some crude extracts, arjunolic acid and bergenin, were screened in vivo and/or in vitro for their antimalarial activities against a chloroquine resistant strain. Structures of all isolated compounds were elucidated by spectroscopic analysis, including 2D NMR experiments.
    CONCLUSIONS:
    All isolates, with the exception of the isocoumarin bergenin, and identified compounds as well as antimalarial activities, are described for the first time for this species.
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