Infractin | CAS:91147-07-8 | Manufacturer ChemFaces

Infractin

$Infractin$

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Infractin Description

Source:	The barks of Picrasma quassioides
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Liebigs Annalen der Chemie, 1993, 1993(2).

Synthesis of Manzamine C, Infractine and 6‐Hydroxyinfractine.[Reference: WebLink]

METHODS AND RESULTS:
Manzamine C (1), a β‐carboline alkaloid with antitumor activity isolated from the marine sponge Haliclona sp. was synthesized. The dilithium derivative of 5‐hexynoic acid (6) was alkylated with 7 to give after esterification the methyl 10‐hydroxy‐5‐decynoate (8). The tosylate of 8 was converted into the azide 9 which could be selectively hydrogenated with Lindlar palladium catalyst to give the amino ester 10. Saponification of 10 and acylation with (Boc)2O yielded 11, which was converted with pentafluorophenol into 12. Removal of the Boc group in 12 gave an amino ester as intermediate, which cyclized immediately under high dilution conditions to give the lactam 13 in high yield. Reduction of 13 with LiAlH4 produced the macrocyclic amine 4. The β‐carboline part of 1 was prepared by condensation of N‐benzyltryptamine 14 with the formylacetic acid equivalent 15 to give 16. Dehydrogenation of 16 with Pd‐on‐carbon catalyst led to the orthoester 17, which could be converted into the methyl ester 5 in high overall yield. The 4‐(dimethylamino)pyridine‐catalyzed substitution of the methyl ester function in 5 by the amine 4 gave the amide 29. The analogous reaction of 5 with pyrrolidine or with azacyclotridecane yielded 30 and 31. Reduction of these three amides with LiAlH4 produced 1, 2 and 3.
CONCLUSIONS:
The spectroscopic properties of 1 were identical with those of natural manzamine C. – Condensation of 14 or N‐benzyl‐5‐(benzyloxy)tryptamine (19) with aldehyde 18 yielded the products 20 and 21, which could be dehydrogenated to furnish 22 and 23. From these the methyl esters 24 and 25 with properties identical to those of the known β‐carboline alkaloids Infractine and 6‐hydroxyInfractine could be obtained.

Product Name	Infractin
Price:
CAS No.:	91147-07-8
Catalog No.:	CFN92747
Molecular Formula:	C₁₅H₁₄N₂O₂
Molecular Weight:	254.3 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The barks of Picrasma quassioides
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.9324 mL	19.6618 mL	39.3236 mL	78.6473 mL	98.3091 mL
5 mM	0.7865 mL	3.9324 mL	7.8647 mL	15.7295 mL	19.6618 mL
10 mM	0.3932 mL	1.9662 mL	3.9324 mL	7.8647 mL	9.8309 mL
50 mM	0.0786 mL	0.3932 mL	0.7865 mL	1.5729 mL	1.9662 mL
100 mM	0.0393 mL	0.1966 mL	0.3932 mL	0.7865 mL	0.9831 mL

CFN91399	Tetrahydroharmine	17019-01-1	216.3	C₁₃H₁₆N₂O
CFN91136	Harmidol hydrochloride	6028-07-5	236.7	C₁₂H₁₃ClN₂O
CFN98385	Harmaline	304-21-2	214.3	C₁₃H₁₄N₂O
CFN91937	Harmalacidine	26579-69-1	216.24	C₁₂H₁₂N₂O₂
CFN91825	Harmol	487-03-6	198.2	C₁₂H₁₀N₂O
CFN90341	Harmine hydrochloride	343-27-1	248.71	C₁₃H₁₂N₂O.HCl
CFN98676	Harmine	442-51-3	212.3	C₁₃H₁₂N₂O
CFN90347	Hydroxyevodiamine	1238-43-3	319.36	C₁₉H₁₇N₃O₂
CFN90464	Vincamine	1617-90-9	354.44	C₂₁H₂₆N₂O₃
CFN90467	Vinpocetine	42971-09-5	350.45	C₂₂H₂₆N₂O₂