ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
Isonardosinone
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $144.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Molecules 2022, 27(3),1047.Korean Herb. Med. Inf....2020...Exp Parasitol.2015, 153:160-4Evid Based Complement Alternat Me...2018...Universidade Estadual Paulista...2017...Mol Cells.2015, 38(9):765-72Antioxidants (Basel).2021, 10(8):1300. Cell Biochem Funct.2018, 36(6):303-311
Food Chem.2022, 373(Pt B):131364.Cancers (Basel).2021, 13(17):4327.Nutr Res Pract.2020, 14(5):478-489.Front Cell Dev Biol.2021, 9:588093.Anal Bioanal Chem. 2016, 408(15)Molecules.2019, 24(7):E1290Applied Biological Chem. 2020, 26(63).Plants (Basel).2021, 10(11):2525.
Int J Mol Sci.2019, 20(11):E2734Natural Product Communications...2020...Int J Mol Sci.2021, 22(17):9400. Molecules.2020, 25(11):2599. Integr Cancer Ther.2018, 17(3):832-843Antioxidants (Basel).2020, 9(4):326. Research Square2020, doi: 10.21203.
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Our products had been exported to the following research institutions and universities, And still growing.
University of Illinois at Chicago (USA)Cornell University (USA)University of Malaya (Malaysia)Kamphaengphet Rajabhat University (Thailand)
Charles Sturt University (Denmark)University of Limpopo (South Africa)Periyar University (India)University of Hawaii Cancer Center (USA)
University of Bonn (Germany)Kitasato University (Japan)University of Wisconsin-Madison (USA)
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Isonardosinone
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manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
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Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Food Chem.2019, 275:746-753Wageningen University & Research2018, January 2018Front Aging Neurosci.2019, 11:230Dicle Tip Dergisi2020, 47(2),423-430.J Agric Food Chem.2017, 65(13):2670-2676Nutr Metab (Lond).2019, 16:31Korean J Dent Mater.2018, 45(2):139-146Oncol Lett.2020, 20(4):122.Bioorg Med Chem.2018, 26(14):4201-4208Eur J Pharmacol.2021, 899:174010.
Related Screening Libraries
| Description: |
Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-κB- and MAPK-mediated inflammatory pathways. |
| Targets: |
NF-κB | MAPK |
| In vitro: |
| Inflammation. 2018 Aug;41(4):1215-1228. | | Nardosinone-Type Sesquiterpenes from the Hexane Fraction of Nardostachys jatamansi Attenuate NF-κB and MAPK Signaling Pathways in Lipopolysaccharide-Stimulated BV2 Microglial Cells.[Pubmed: 29616391 ] |
METHODS AND RESULTS:
Four nardosinone-type sesquiterpenes, nardosinone, Isonardosinone, kanshone E, and kanshone B, were isolated from the hexane fraction of Nardostachys jatamansi (Valerianaceae) methanol extract. The structures of these compounds were mainly established by analyzing the data obtained from nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). In this study, we investigated their anti-neuroinflammatory effects in lipopolysaccharide (LPS)-induced BV2 microglial cells. The results showed that nardosinone-type sesquiterpenes inhibited the production of pro-inflammatory mediators, such as nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-induced BV2 microglial cells. These inhibitory effects were correlated with the downregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, these sesquiterpenes also attenuated the mRNA expression of pro-inflammatory cytokines including interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) in LPS-induced BV2 microglial cells. During the evaluation of the signaling pathways involved in these anti-neuroinflammatory effects, western blot analysis and DNA-binding activity assay revealed that the suppression of inflammatory reaction by these sesquiterpenes was mediated by the inactivation of nuclear factor-kappa B (NF-κB) pathway. These sesquiterpenes also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways in LPS-stimulated BV2 microglial cells.
CONCLUSIONS:
Taken together, these four nardosinone-type sesquiterpenes inhibited NF-κB- and MAPK-mediated inflammatory pathways, demonstrating their potential role in the treatment of neuroinflammation conditions. |
|
Isonardosinone Description
| Source: |
The rhizomes and roots of Nardostachys chinensis. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.7836 mL |
18.9179 mL |
37.8358 mL |
75.6716 mL |
94.5895 mL |
| 5 mM |
0.7567 mL |
3.7836 mL |
7.5672 mL |
15.1343 mL |
18.9179 mL |
| 10 mM |
0.3784 mL |
1.8918 mL |
3.7836 mL |
7.5672 mL |
9.4589 mL |
| 50 mM |
0.0757 mL |
0.3784 mL |
0.7567 mL |
1.5134 mL |
1.8918 mL |
| 100 mM |
0.0378 mL |
0.1892 mL |
0.3784 mL |
0.7567 mL |
0.9459 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
