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    Natural Products
    N1,N5,N10-(Z)-tri-p-coumaroylspermidine
    N1,N5,N10-(Z)-tri-p-coumaroylspermidine
    Information
    CAS No. 131086-78-7 Price $388 / 5mg
    Catalog No.CFN95253Purity>=98%
    Molecular Weight583.7Type of CompoundAlkaloids
    FormulaC34H37N3O6Physical DescriptionOil
    Download     COA    MSDSSimilar structuralComparison (Web)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $446.2 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    N1,N5,N10-(Z)-tri-p-coumaroylspermidine

    N1,N5,N10-(Z)-tri-p-coumaroylspermidine
    Product Name N1,N5,N10-(Z)-tri-p-coumaroylspermidine
    CAS No.: 131086-78-7
    Catalog No.: CFN95253
    Molecular Formula: C34H37N3O6
    Molecular Weight: 583.7 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Oil
    Source: The herbs of Helianthus annuus L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $388 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Bull. Pharm. Sci., Assiut University2020, 43(2):149-155.
  • Phytomedicine.2015, 22(11):1027-36
  • Ind Crops Prod.2014, 62:173-178
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
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  • Front Endocrinol (Lausanne).2020, 11:568436.
  • J of Ana. Chem.2019, 74(11):1113-1121
  • Molecules.2020, 25(18),4089.
  • International Food Research Journal2018, 25(6):2560-2571
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Alkaloids Compound Library
  • Biological Activity
    Description: N1,N5,N10-(Z)-tri-p-coumaroylspermidine shows weak inhibition effect on [3H]-5-HT reuptake in rat brain synaptosomes.
    In vitro:
    Journal of Shanxi Medical University, 2015.
    Isolation and purification of coumaroylspermidines from Carthamus tinctorius L. and their inhibition effects on [~3H]-5-HT reuptake.[Reference: WebLink]
    To isolate and purify coumaroylspermidines from Carthamus tinctorius L.,and to investigate their inhibition effects on [3H]-5-HT reuptake and the photoisomerization behavior of coumaroylspermidines.
    METHODS AND RESULTS:
    Coumaroyl spermidines were isolated and purified by medium pressure flash chromatography,Sephadex LH-20 column chromatographies and preparative HPLC. The chemical structures were identified by ESI-MS and1H-NMR. The inhibition effects of coumaroylspermidines on [3H]-5-HT reuptake in rat brain synaptosomes were studied by classical method. Photoisomerization behaviors of coumaroylspermidines were investigated by HPLC. Results Four coumaroylspermidines were isolated and identified as N1,N5,N10-(Z)-tri-p-coumaroylspermidine(1), N1,N5-( Z)-N10-( E)-tri-p-coumaroylspermidine(2),N1( E)-N5-( Z)-N10-( E)-tri-p-coumaroylspermidine(3),N1,N5,N10-( E)-tri-pcoumaroylspermidine(4). Coumaroylspermidine 2 and 3 showed better inhibition effects on [3H]-5-HT reuptake in rat brain synaptosomes,while coumaroylspermidine 1 showed weaker inhibition effect. The photoisomerization behavior studies showed that the four coumaroylspermidines transformed into each other under sunlight and finally reached an equilibrium state.
    CONCLUSIONS:
    Coumaroylspermidines could have inhibition effects on 5-HT reuptake and the inhibition effects could be different for different isomers. Coumaroylspermidines are unstable and could show photoisomerization behavior under sunlight.
    N1,N5,N10-(Z)-tri-p-coumaroylspermidine Description
    Source: The herbs of Helianthus annuus L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7132 mL 8.566 mL 17.1321 mL 34.2642 mL 42.8302 mL
    5 mM 0.3426 mL 1.7132 mL 3.4264 mL 6.8528 mL 8.566 mL
    10 mM 0.1713 mL 0.8566 mL 1.7132 mL 3.4264 mL 4.283 mL
    50 mM 0.0343 mL 0.1713 mL 0.3426 mL 0.6853 mL 0.8566 mL
    100 mM 0.0171 mL 0.0857 mL 0.1713 mL 0.3426 mL 0.4283 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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