ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Ind Crops Prod.2014, 62:173-178Tumour Biol.2015, 36(9):7027-34Acta Pharm Sin B.2015, 5(4):323-9.J Pharm Biomed Anal.2016, 129:50-59J Ethnopharmacol.2016, 194:219-227Braz J Med Biol Res. 2016, 49(7)Nutrients.2017, 10(1)Acta horticulturae2017, 1158:257-268
African J. Agricultural Research ...2017...J Ethnopharmacol.2017, 209:305-316BMC Pharmacol Toxicol.2018, 19(1):5Front Cell Infect Microbiol.2018, 8:292J Cancer.2019, 10(23):5843-5851J Chromatogr B Analyt Technol Bio...2019...Molecules.2019, 24(24):E4536Pak J Pharm Sci.2019, 32(6):2879-2885
FASEB J.2019, 33(8):9685-9694Nutrients2020, 12(3):811.Nutrients.2020, 12(5):1242.Int J Mol Sci.2020, 21(22):8816. Bioorg Med Chem.2020, 28(12):115553.Horticulturae2021, 7(1),5.Evid Based Complement Alternat Me...2021...
Our products had been exported to the following research institutions and universities, And still growing.
University of Lodz (Poland)Ateneo de Manila University (Philippines)Mahidol University (Thailand)University of British Columbia (Canada)
University of Amsterdam (Netherlands)Hamdard University (India)Monash University (Australia)Lund University (Sweden)
University of Wollongong (Australia)The Australian National University (Australia)Calcutta University (India)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Int J Mol Sci.2019, 20(21):E5488Anat Rec2018, 24264Oncotarget.2017, 9(3):4161-4172Mediators Inflamm. 2016, 2016:6189590ACS Synth Biol.2020, 9(9):2282-2290.Braz J Med Biol Res. 2016, 49(7)Front Plant Sci.2020, 10:1705J Bone Miner Res.2017, 32(12):2415-2430J Biochem Mol Toxicol.2020, 34(7):e22489.J Biol Chem.2014, 289(3):1723-31
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Alkaloids Compound Library
||The herbs of Rauvolfia verticillata
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Org Chem. 2014 Nov 7;79(21):10030-48. |
|General strategy for synthesis of C-19 methyl-substituted sarpagine/macroline/ajmaline indole alkaloids including total synthesis of 19(S),20(R)-dihydroperaksine, 19(S),20(R)-dihydroperaksine-17-al, and peraksine.[Pubmed: 25247616]|
METHODS AND RESULTS:
A detailed account of the development of a general strategy for synthesis of the C-19 methyl-substituted alkaloids including total synthesis of 19(S),20(R)-dihydroPeraksine-17-al (1), 19(S),20(R)-dihydroPeraksine (2), and Peraksine (6) is presented. Efforts directed toward the total synthesis of macrosalhine chloride (5) are also reported. Important to success is the sequence of chemical reactions which include a critical haloboration reaction, regioselective hydroboration, and controlled oxidation (to provide sensitive enolizable aldehydes at C-20). In addition, the all-important Pd-catalyzed α-vinylation reaction has been extended to a chiral C-19 alkyl-substituted substrate for the first time.
Synthesis of the advanced intermediate 64 completes an improved formal total synthesis of talcarpine (26) and provides a starting point for synthesis of macroline-related alkaloids 27-31.
Similarly, extension of this synthetic strategy in the ring A oxygenated series should provide easy access to the northern hemisphere 32b of the bisindoles angustricraline, alstocraline, and foliacraline (Figure 4 ).
|J Ethnopharmacol. 1984 Jun;11(1):99-117. |
|Stem bark alkaloids of Rauvolfia caffra.[Pubmed: 6471882]|
METHODS AND RESULTS:
Thirty two alkaloids were isolated from the stem bark of Rauvolfia caffra and 28 were identified. The alkaloids represented corynane (3), strictamine (1), sarpagan (4), akuammicine (2), pleiocarpamine (1), indolenine (1), dihydroindole (6), Peraksine (3), heteroyohimbine (2), hydroxyheteroyohimbine (2), oxindole (1), 2-acyl-indole (1), suaveoline (3) and yohimbine (2) types. The anhydronium base serpentine was detected but not isolated.
The principal alkaloids were ajmaline and norajmaline (dihydroindoles), ajmalicinine and ajmalicine (heteroyohimbines), geissoschizol (E-seco indole) and pleiocarpamine and the heteroyohimbine derived alkaloids were predominantly normal configuration compounds.
The biosynthetic and ethnopharmacological significance of the alkaloids is discussed.