Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Polygalaxanthone III
    Information
    CAS No. 162857-78-5 Price $138 / 20mg
    Catalog No.CFN90208Purity>=98%
    Molecular Weight568.39Type of CompoundXanthones
    FormulaC25H28O15Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $64.6 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Universite Libre de Bruxelles (Belgium)
  • Northeast Normal University Cha... (China)
  • Indian Institute of Science (India)
  • National Cancer Institute (USA)
  • Regional Crop Research Institute (Korea)
  • Aarhus University (Denmark)
  • The Vancouver Prostate Centre (... (Canada)
  • Universidade Federal de Santa C... (Brazil)
  • Hamdard University (India)
  • University of East Anglia (United Kingdom)
  • Pennsylvania State University (USA)
  • More...
  • Package
    Featured Products
    Deapi-platycodin D3

    Catalog No: CFN92269
    CAS No: 67884-05-3
    Price: $238/5mg
    Isoacteoside

    Catalog No: CFN97049
    CAS No: 61303-13-7
    Price: $178/20mg
    4-O-Feruloylquinic acid

    Catalog No: CFN92392
    CAS No: 2613-86-7
    Price: $448/5mg
    Ganoderic acid S

    Catalog No: CFN99066
    CAS No: 104759-35-5
    Price: $568/5mg
    Glycitin

    Catalog No: CFN99105
    CAS No: 40246-10-4
    Price: $70/20mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $/mg
    Decursitin D

    Catalog No: CFN95002
    CAS No: 245446-61-1
    Price: $388/5mg

    Polygalaxanthone III

    Polygalaxanthone III
    Product Name Polygalaxanthone III
    CAS No.: 162857-78-5
    Catalog No.: CFN90208
    Molecular Formula: C25H28O15
    Molecular Weight: 568.39 g/mol
    Purity: >=98%
    Type of Compound: Xanthones
    Physical Desc.: Powder
    Targets: P450 (e.g. CYP17)
    Source: The roots of Polygala tenuifolia Willd.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $138 / 20mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Journal of Oil Palm Research2019, 31(2):238-247
  • Neurochem Int.2020, 133:104629
  • University of Limpopo2016, 1777
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Analytical sci. & Tech2016, 186-193
  • Anticancer Res.2018, 38(4):2127-2135
  • Eur J Pharmacol.2020, 889:173589.
  • Adaptive Medicine 2020, 12(1): 4-10
  • Analytical methods2019, 11(6)
  • Phytother Res.2019, 33(3):676-689
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Neuroprotection Compound Library
  • Xanthones Compound Library
  • P450 (e.g. CYP17) Inhibitor Library
  • Biological Activity
    Description: Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.
    Targets: P450 (e.g. CYP17)
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4459-63.
    [Effect of oligosaccharide esters and polygalaxanthone Ill from Polygala tenuifolia willd towards cytochrome P450].[Pubmed: 25850285]

    METHODS AND RESULTS:
    Five compounds (tenuifoliside C, tenuifoliside D, telephiose A, telephiose C and Polygalaxanthone III) from polygala tenuifolia wild were incubated together with CYP probe substrate in human liver microsomes to investigate the inhibitory effect towards CYP450 enzyme. Phenacetin (CYP1A2), coumarin (CYP2A6), paclitaxel (CYP2C8), diclofenac (CYP2C9), S-mepheriytoin (CYP2C19), dextromethorphan (CYP2D6), chlorzoxazone (CYP2E1), midazolam (CYP3A) were selected as the isoforfn specific substrate. And the formation of paracetamol, 7-hydroxycoumarin, 6alpha-hydroxy paclitaxel, 4'-hydroxydiclofenac, dextrorphan, 6-hydroxychlorzoxazone, 1'-hydroxymidazolam, 4'-hydroxymephenytoin were detected respectively to measure the effect towards CYP450 by high-pressure liquid chromatography (HPLC).
    CONCLUSIONS:
    The result shows that five compounds from polygala tenuifolia willd significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1, while showed no effect towards CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A. And IC50 value was 38.73, 54.14, 61.77, 62.22, 50.56 micromol x L(-1), respectively.
    Polygalaxanthone III Description
    Source: The roots of Polygala tenuifolia Willd.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Isochlorogenic acid A

    Catalog No: CFN99118
    CAS No: 2450-53-5
    Price: $108/20mg
    Quercetin 3-O-beta-(6''-p-coumaroy...

    Catalog No: CFN95088
    CAS No: 143061-65-8
    Price: $338/10mg
    Ganoderic acid C6

    Catalog No: CFN92290
    CAS No: 105742-76-5
    Price: $368/10mg
    Cornin

    Catalog No: CFN98160
    CAS No: 548-37-8
    Price: $138/20mg
    Daucoidin A

    Catalog No: CFN95275
    CAS No: 103629-87-4
    Price: $318/5mg
    Juglanin

    Catalog No: CFN96238
    CAS No: 5041-67-8
    Price: $318/5mg
    9-O-Acetyl-fargesol

    Catalog No: CFN95031
    CAS No: 449172-61-6
    Price: $413/5mg
    Gynosaponin TN2

    Catalog No: CFN95331
    CAS No: 77658-95-8
    Price: $318/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7594 mL 8.7968 mL 17.5936 mL 35.1871 mL 43.9839 mL
    5 mM 0.3519 mL 1.7594 mL 3.5187 mL 7.0374 mL 8.7968 mL
    10 mM 0.1759 mL 0.8797 mL 1.7594 mL 3.5187 mL 4.3984 mL
    50 mM 0.0352 mL 0.1759 mL 0.3519 mL 0.7037 mL 0.8797 mL
    100 mM 0.0176 mL 0.088 mL 0.1759 mL 0.3519 mL 0.4398 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Mass Spectrom. 2013 Aug;48(8):904-13.
    A UFLC-MS/MS method with a switching ionization mode for simultaneous quantitation of polygalaxanthone III, four ginsenosides and tumulosic acid in rat plasma: application to a comparative pharmacokinetic study in normal and Alzheimer's disease rats.[Pubmed: 23893636]

    METHODS AND RESULTS:
    A fast, sensitive and reliable ultra fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method has been developed and validated for simultaneous quantitation of Polygalaxanthone III (POL), ginsenoside Rb1 (GRb1), ginsenoside Rd (GRd), ginsenoside Re (GRe), ginsenoside Rg1 (GRg1) and tumulosic acid (TUM) in rat plasma after oral administration of Kai-Xin-San, which plays an important role for the treatment of Alzheimer's disease (AD). The plasma samples were extracted by liquid-liquid extraction using ethyl acetate-isopropanol (1:1, v/v) with salidrdoside as internal standard (IS). Good chromatographic separation was achieved using gradient elution with the mobile phase consisting of methanol and 0.01% acetic acid in water. The tandem mass spectrometric detection was performed in multiple reaction monitoring mode on 4000Q UFLC-MS/MS system with turbo ion spray source in a negative and positive switching ionization mode. The lower limits of quantification were 0.2-1.5 ng/ml for all the analytes. Both intra-day and inter-day precision and accuracy of analytes were well within acceptance criteria (±15%). The mean absolute extraction recoveries of analytes and IS from rat plasma were all more than 60.0%. The validated method has been successfully applied to comparing pharmacokinetic profiles of analytes in normal and AD rat plasma.
    CONCLUSIONS:
    The results indicated that no significant differences in pharmacokinetic parameters of GRe, GRg1 and TUM were observed between the two groups, while the absorption of Polygalaxanthone III and GRd in AD group were significantly higher than those in normal group; moreover, the GRb1 absorbed more rapidly in model group. The different characters of pharmacokinetics might be caused by pharmacological effects of the analytes.
    Deapi-platycodin D3

    Catalog No: CFN92269
    CAS No: 67884-05-3
    Price: $238/5mg
    Isoacteoside

    Catalog No: CFN97049
    CAS No: 61303-13-7
    Price: $178/20mg
    4-O-Feruloylquinic acid

    Catalog No: CFN92392
    CAS No: 2613-86-7
    Price: $448/5mg
    Ganoderic acid S

    Catalog No: CFN99066
    CAS No: 104759-35-5
    Price: $568/5mg
    Glycitin

    Catalog No: CFN99105
    CAS No: 40246-10-4
    Price: $70/20mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $/mg
    Decursitin D

    Catalog No: CFN95002
    CAS No: 245446-61-1
    Price: $388/5mg