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Pyracrenic acid
Pyracrenic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Pyracrenic acid
Price:
CAS No.: 80832-44-6
Catalog No.: CFN89164
Molecular Formula: C39H54O6
Molecular Weight: 618.85 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The aerial roots of Ficus microcarpa.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Pyracrenic acid is a potent elastase inhibitor with an IC50 value of 1.5 mg/mL. Pyracrenic acid shows DPPH radical scavenging activity. It also shows significant cytotoxic activities against human cancer cells COLO 205 and AGS.
In vitro:
Chem Biodivers. 2008 Apr;5(4):565-74.
Cytotoxic triterpenoids from the root bark of Helicteres angustifolia.[Pubmed: 18421748 ]

METHODS AND RESULTS:
Three new triterpenoids, 3beta-acetoxy-27-[(E)-cinnamoyloxy]lup-20(29)-en-28-oic acid methyl ester (1), 3beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]lup-20(29)-en-28-oic acid (2), and 3beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]olean-12-en-28-oic acid methyl ester (3), together with nine known triterpenoids, 4-12, were isolated from the root bark of Helicteres angustifolia. The structures of these compounds were established on the basis of spectroscopic methods including 2D-NMR experiments. All twelve compounds were tested for their cytotoxic activities against human colorectal cancer (COLO 205), human hepatoma (Hep G2), and human gastric cancer (AGS) cell lines in vitro.
CONCLUSIONS:
Among them, compounds 2, 3, 3beta-O-[(E)-coumaroyl]betulinic acid (6), and Pyracrenic acid (7) showed significant cytotoxic activities against human cancer cells COLO 205 and AGS.
Pyracrenic acid Description
Source: The aerial roots of Ficus microcarpa.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6159 mL 8.0795 mL 16.159 mL 32.318 mL 40.3975 mL
5 mM 0.3232 mL 1.6159 mL 3.2318 mL 6.4636 mL 8.0795 mL
10 mM 0.1616 mL 0.808 mL 1.6159 mL 3.2318 mL 4.0398 mL
50 mM 0.0323 mL 0.1616 mL 0.3232 mL 0.6464 mL 0.808 mL
100 mM 0.0162 mL 0.0808 mL 0.1616 mL 0.3232 mL 0.404 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Journal of Medicinal Plant Research, 2009, 3(11):914-920.
Compounds with elastase inhibition and free radical scavenging activities from Callistemon lanceolatus.[Reference: WebLink]

METHODS AND RESULTS:
Bioassay-guided investigation of the stems of Callistemon lanceolatus led to the isolation of five compounds such as betulinic acid (1), Pyracrenic acid (2), arjunolic acid (3), catechin (4), and piceatannol (5). Their structures were elucidated on the basis of spectral studies as well as by comparison with literature data. Elastase inhibition and DPPH radical scavenging activities wereinvestigated for the isolated compounds.
CONCLUSIONS:
Among these, Pyracrenic acid (2) was identified as a potent elastase inhibitor with an IC50 value of 1.5 mg/mL, more active than the control compound, oleanolic acid (IC50 = 3.0 mg/mL). With regard to antioxidative studies, strong to moderate DPPH radical scavenging activities were observed with Pyracrenic acid (2), catechin (4) and piceatanol (5).
Structure Identification:
Zhong Yao Cai. 2012 Jun;35(6):904-8.
Chemical constituents from the aerial roots of Ficus microcarpa.[Pubmed: 23236824]
To study the chemical constituents of the aerial roots of Ficus microcarpa.
METHODS AND RESULTS:
The compounds were isolated and purified by column chromatographic methods on silica gel and Sephadex LH-20. Their structures were elucidated by physicochemical properties and spectral data. RESULTS: 12 compounds were isolated from the 95% ethanol extract. Their structures were idenified as 3beta-hydroxy-11-oxours-12-ene (1), 3beta-acetoxy-11-oxours-12-ene (2), oleanic acid (3), 3beta-hydroxy-oleana-11,13 (18)-dien-28-oic acid (4), betulinic acid (5), Pyracrenic acid (6), platanic acid (7), isowigtheone (8), myrsininone A (9), derrone (10), alpinumisoflavone (11) and caffeic acid methyl ester (12), respectively.
CONCLUSIONS:
Compounds 4, 6, 12 are obtained from this genus for the first time, compounds 1, 7 - 11 are isolated from this plant for the first time.
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