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    Natural Products
    cis-3,7-Dimethyl-2,6-octadien-1-ol
    cis-3,7-Dimethyl-2,6-octadien-1-ol
    Information
    CAS No. 106-25-2 Price $30 / 20mg
    Catalog No.CFN70013Purity>=98%
    Molecular Weight154.2Type of CompoundMonoterpenoids
    FormulaC10H18OPhysical DescriptionOil
    Download COA    MSDSSimilar structuralComparison
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $7.0 / In-stock
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    cis-3,7-Dimethyl-2,6-octadien-1-ol

    cis-3,7-Dimethyl-2,6-octadien-1-ol
    Product Name cis-3,7-Dimethyl-2,6-octadien-1-ol
    CAS No.: 106-25-2
    Catalog No.: CFN70013
    Molecular Formula: C10H18O
    Molecular Weight: 154.2 g/mol
    Purity: >=98%
    Type of Compound: Monoterpenoids
    Physical Desc.: Oil
    Source:
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $30 / 20mg
    Download: COA    MSDS
    Similar structural: Comparison
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
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    Description: Reference standards.
    cis-3,7-Dimethyl-2,6-octadien-1-ol Description
    Source:
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.4851 mL 32.4254 mL 64.8508 mL 129.7017 mL 162.1271 mL
    5 mM 1.297 mL 6.4851 mL 12.9702 mL 25.9403 mL 32.4254 mL
    10 mM 0.6485 mL 3.2425 mL 6.4851 mL 12.9702 mL 16.2127 mL
    50 mM 0.1297 mL 0.6485 mL 1.297 mL 2.594 mL 3.2425 mL
    100 mM 0.0649 mL 0.3243 mL 0.6485 mL 1.297 mL 1.6213 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Plant Physiol Biochem, 2017:359-368.
    Structural and kinetic studies of a novel nerol dehydrogenase from Persicaria minor, a nerol-specific enzyme for citral biosynthesis.[Reference: WebLink]
    Geraniol degradation pathway has long been elucidated in microorganisms through bioconversion studies, yet weakly characterised in plants; enzyme with specific nerol-oxidising activity has not been reported. A novel cDNA encodes nerol dehydrogenase (PmNeDH) was isolated from Persicaria minor.
    METHODS AND RESULTS:
    The recombinant PmNeDH (rPmNeDH) is a homodimeric enzyme that belongs to MDR (medium-chain dehydrogenases/reductases) superfamily that catalyses the first oxidative step of geraniol degradation pathway in citral biosynthesis. Kinetic analysis revealed that rPmNeDH has a high specificity for allylic primary alcohols with backbone ≤10 carbons. rPmNeDH has ∼3 fold higher affinity towards nerol (cis-3,7-Dimethyl-2,6-octadien-1-ol) than its trans-isomer, geraniol. To our knowledge, this is the first alcohol dehydrogenase with higher preference towards nerol, suggesting that nerol can be effective substrate for citral biosynthesis in P. minor. The rPmNeDH crystal structure (1.54 Å) showed high similarity with enzyme structures from MDR superfamily. Structure guided mutation was conducted to describe the relationships between substrate specificity and residue substitutions in the active site. Kinetics analyses of wild-type rPmNeDH and several active site mutants demonstrated that the substrate specificity of rPmNeDH can be altered by changing any selected active site residues (Asp280, Leu294 and Ala303). Interestingly, the L294F, A303F and A303G mutants were able to revamp the substrate preference towards geraniol. Furthermore, mutant that exhibited a broader substrate range was also obtained.
    CONCLUSIONS:
    This study demonstrates that P. minor may have evolved to contain enzyme that optimally recognise cis-configured nerol as substrate. rPmNeDH structure provides new insights into the substrate specificity and active site plasticity in MDR superfamily.
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