- ChemFaces is a professional high-purity natural products manufacturer.
- Product Intended Use
- 1. Reference standards
- 2. Pharmacological research
- 3. Inhibitors
ChemFaces products have been cited in many studies from excellent and top scientific journals
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Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $7.0 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
- Foods.2020, 9(10):1348.
- Biomedicines.2022, 10(5):1170
- Arch Biochem Biophys.2020, 687:108384.
- Evid Based Complement Alternat Me...2021...
- Molecules.2019, 24(6):E1177
- Chem Biol Interact.2016, 258:59-68
- Antioxidants (Basel).2020, 9(11):1121.
- Phytother Res.2019, 33(3):676-689
- Agriculture2022, 12(2),227.
- Antioxidants (Basel).2021, 10(9):1435.
- Molecules.2018, 23(7):E1659
- Sci Rep.2017, 7:467-479
- Biomed Pharmacother.2021, 137:111362.
- Int Immunopharmacol.2019, 71:22-31
- Molecules.2020, 25(18):4283.
- Food Quality and Safety2018, 2:213-219
- J Chromatogr Sci.2015, 53(5):824-9
- Biosci Biotechnol Biochem....2020...
- Oncotarget.2017, 8(53):90925-90947
- Cell Physiol Biochem....2017...
- J Ethnopharmacol.2020, 254:112733.
- China Pharmacy2015, 26(27)
- Sci Rep.2021, 11(1):14180.
Our products had been exported to the following research institutions and universities, And still growing.
- Instituto Politécnico de Bragan?a (Portugal)
- University of Zurich (Switzerland)
- Sapienza University of Rome (Italy)
- University of Eastern Finland (Finland)
- The University of Newcastle (Australia)
- Max-Planck-Insitut (Germany)
- Hamdard University (India)
- Deutsches Krebsforschungszentrum (Germany)
- Aarhus University (Denmark)
- Shanghai University of TCM (China)
- Martin Luther University of Hal... (Germany)
- Foods.2021, 10(12):2929.
- The Journal of Phytopharmacology2020, 9(1): 1-4
- Chem Biol Interact.2020, 328:109200.
- Plant Methods.2017, 13:108
- J Food Biochem.2019, 43(9):e12970
- Integr Med Res.2021, 10(3):100723.
- Foods.2020, 9(10):1348.
- Applied Biological Chemistry2020, 63:33(2020)
- J Nat Prod.2018, 81(4):966-975
- Int J Mol Sci. 2014, 15(5):8443-57
Related Screening Libraries
|| Reference standards.|
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Plant Physiol Biochem, 2017:359-368. |
|Structural and kinetic studies of a novel nerol dehydrogenase from Persicaria minor, a nerol-specific enzyme for citral biosynthesis.[Reference: WebLink]|
|Geraniol degradation pathway has long been elucidated in microorganisms through bioconversion studies, yet weakly characterised in plants; enzyme with specific nerol-oxidising activity has not been reported. A novel cDNA encodes nerol dehydrogenase (PmNeDH) was isolated from Persicaria minor.
METHODS AND RESULTS:
The recombinant PmNeDH (rPmNeDH) is a homodimeric enzyme that belongs to MDR (medium-chain dehydrogenases/reductases) superfamily that catalyses the first oxidative step of geraniol degradation pathway in citral biosynthesis. Kinetic analysis revealed that rPmNeDH has a high specificity for allylic primary alcohols with backbone ≤10 carbons. rPmNeDH has ∼3 fold higher affinity towards nerol (cis-3,7-Dimethyl-2,6-octadien-1-ol) than its trans-isomer, geraniol. To our knowledge, this is the first alcohol dehydrogenase with higher preference towards nerol, suggesting that nerol can be effective substrate for citral biosynthesis in P. minor. The rPmNeDH crystal structure (1.54 Å) showed high similarity with enzyme structures from MDR superfamily. Structure guided mutation was conducted to describe the relationships between substrate specificity and residue substitutions in the active site. Kinetics analyses of wild-type rPmNeDH and several active site mutants demonstrated that the substrate specificity of rPmNeDH can be altered by changing any selected active site residues (Asp280, Leu294 and Ala303). Interestingly, the L294F, A303F and A303G mutants were able to revamp the substrate preference towards geraniol. Furthermore, mutant that exhibited a broader substrate range was also obtained.
This study demonstrates that P. minor may have evolved to contain enzyme that optimally recognise cis-configured nerol as substrate. rPmNeDH structure provides new insights into the substrate specificity and active site plasticity in MDR superfamily.