Screening Libraries
| Cat. | Size | Price | Stock | |
| P20494 | 1mg/well * 17 Compounds | Inquiry | In stock | Contact Us |
| P20494 | 100uL/well (10mM solution) * 17 Compounds | Inquiry | In stock |
| manager@chemfaces.com | |
| Tel | (0086)-27-8423-7683 |
| Shelf Life | (0086)-27-84254680 |
| Manufacturer | Wuhan ChemFaces Biochemical Co., Ltd. |
| Container | 96 Well Format Sample |
| Storage | Protected from air and light, refrigerate or freeze(2-8 °) |
| Shelf Life | 24 months (2-8 °) |
| Intended Use | For research use only. Not for human use. Not sell to patients |
| 1. The products in the ChemFaces screening libraries are all from plants. |
| 2. The biological activities or pharmacological activities of all the ChemFaces products are derived from the databases of all over the world the latest literatures, you can according to the product manuals on our website to access the relevant literatures, hope that our informations can give some inspirations and help to your research. |
| 3.The collections of unique natural products, which include antioxidants, anti-inflammatory, antibacterial, anticancer, and ect. Can be used for high throughput screening (HTS) and high content screening (HCS), is to help you carry out new drug screening, the emergence of new indications and other professional tools. |
| 4.Structurally diverse, medicinally active, and cell permeable, NMR and HPLC validated to ensure high purity. |
| 5. ChemFaces offers customized bioactive screening libraries , whereby you choose the specific compounds you want in the library, the quantities, plate map, concentration, and format (dry/solid or DMSO solution). |
| Catalog No. | Information |
| CFN99748 | (+)-Bicuculline (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.It is effective in vitro against spore germination of some plant pathogenic fungi, it can significantly inhibit spore germination of all the fungi at concentrations of 100-1000 ppm. |
| CFN99745 | (+)-Corynoline Corynoline is a reversible and noncompetitive inhibitor of acetylcholinesterase(AChE) with the IC50 value of 30.6 microM, which exhibits the potent anti-inflammatory and/or immunosuppressive activity, the potent inhibitory activity of corynoline for the ICAM-1/LFA-1 adhesion and would be important on developing the clinically usable drugs for the inflammatory diseases. |
| CFN99553 | Tetrahydropalmatine Tetrahydropalmatine, a plant alkaloid used as an ingredient in dietary supplement products, is a potent and selective D1 receptor antagonist. Tetrahydropalmatine shows a promyogenic effect by upregulation of p38MAPK, Akt resulting in enhanced MyoD activation, it can effectively protect endothelial cells against γ-irradiation injury. Tetrahydropalmatine has a potential as a therapeutic candidate to prevent fibrosis and improve muscle regeneration and repair and applied to the prevention of endothelial cell dysfunctions associated with ionizing irradiation-induced lung injury. |
| CFN99399 | Protopine Protopine acts as a potent inhibitor of thromboxane synthesis and PAF with hepatoprotective, antidepressant, antioxidant, antispasmodic and relaxant properties. Protopine is also a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Protopine blocks phosphorylation of mitogen-activated protein kinases (MAP kinases) and also blocks activation of a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). |
| CFN98564 | Epiberberine Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean); it also exhibits predominant cholinesterases (ChEs) inhibitory effects with IC(50) values ranging between 0.44-1.07 microM for AChE and 3.32-6.84 microM for BChE. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte differentiation. Epiberberine also ha anti-alzheimer and antioxidant activities. |
| CFN98493 | Jatrorrhizine Jatrorrhizine has neuroprotective, antioxidative, anti-inflammatory, antihypercholesterolemic, and anti-hyperglycemia effects.Jatrorrhizine is expected to be developed as a new gastric prokinetic drug, it is metabolized by human CYP1A2 and multiple UGT1A isoforms. It has inhibitory activities against the expression of inducible NO syntase (iNOS) and cyclooxygenase-2 (COX-2), and can improve the utilization and excretion of cholesterol by up-regulating the mRNA and protein expression of LDLR and CYP7A1. |
| CFN98459 | Palmatine Palmatine shows significant antidepressant-like, anti-hyperlipidemia, hepatoprotective, and antioxidant effects, it inhibited MAO-A, I(K) and I(CRAC) activity, and activated the AhR-CYP1A pathway. Palmatine shows the strong toxic action on T. thermophila BF5 growth, it is toxic to insects and vertebrates and inhibited the multiplication of bacteria, fungi and viruses, it is active at the alpha 2-receptor ( IC50 of 956 nM). |
| CFN90431 | Dihydroberberine Dihydroberberine has anti-tumor activity. It also improves in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents, thus is potential therapeutic reagents for type 2 diabetes treatment. |
| CFN90196 | Corydaline Corydaline is an acetylcholinesterase inhibitor, is also an inhibitor of CYP2C19 and CYP2C9. Corydaline has antiallergic, and antinociceptive activities. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastric accommodation. |
| CFN99749 | Acetylcorynoline Acetylcorynoline has anti-inflammatory properties, it also has potential to improve parkinson's disease, it may exert its effects by decreasing egl-1 expression to suppress apoptosis pathways and by increasing rpn5 expression to enhance the activity of proteasomes. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. It has protective action against experimental liver injury in mice. |
