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    Screening Libraries
    P-gp Inhibitor Library
    A unique collection of 74 P-gp Inhibitor Library for high throughput screening (HTS), high content screening (HCS) and New drug research
    Cat. Size Price Stock
    T100391mg/well * 74 CompoundsInquiry In stock
    Contact Us
    T10039100uL/well (10mM solution) * 74 CompoundsInquiry In stock
    *You can select compounds, quantities, format (dry/solid or DMSO) and plate map to meet your specific requirement.
    Contact Us
    E-mail manager@chemfaces.com
    Tel (0086)-27-8423-7683
    Shelf Life (0086)-27-84254680
    ManufacturerWuhan ChemFaces Biochemical Co., Ltd.
    Package & Storage
    Container 96 Well Format Sample
    Storage Protected from air and light, refrigerate or freeze(2-8 °)
    Shelf Life 24 months (2-8 °)
    Intended UseFor research use only. Not for human use. Not sell to patients
    Description & Advantages
    1. The products in the ChemFaces screening libraries are all from plants.
    2. The biological activities or pharmacological activities of all the ChemFaces products are derived from the databases of all over the world the latest literatures, you can according to the product manuals on our website to access the relevant literatures, hope that our informations can give some inspirations and help to your research.
    3.The collections of unique natural products, which include antioxidants, anti-inflammatory, antibacterial, anticancer, and ect. Can be used for high throughput screening (HTS) and high content screening (HCS), is to help you carry out new drug screening, the emergence of new indications and other professional tools.
    4.Structurally diverse, medicinally active, and cell permeable, NMR and HPLC validated to ensure high purity.
    5. ChemFaces offers customized bioactive screening libraries , whereby you choose the specific compounds you want in the library, the quantities, plate map, concentration, and format (dry/solid or DMSO solution).
    Natural Products
    Catalog No. Information
    CFN99050 Phyllanthin

    Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.
    CFN99185 Demethoxycurcumin

    Demethoxycurcumin is a potential additive natural product in combination with chemotherapeutic agents in drug-resistant cancers, which has anti-acanthamoebic, anti-proliferative, antimetastatic, anti-inflammatory, antioxidant activities. It inhibited P-glycoprotein-mediated ATP hydrolysis under concentrations of <1 μM and efficiently inhibited 200 μM verapamil-stimulated ATPase activity.
    CFN99518 Muscone

    Muscone, a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk. Muscone has neuroprotective, anti-fibrotic, anti-inflammatory and anti-apoptotic effects, it can protect PC12 cells against glutamate -induced apoptosis by attenuating ROS generation and Ca2+ influx, via NR1 and CaMKII-depended ASK-1/JNK/p38 signaling pathways. Muscone can permeate the BBB model, and it is associated with the inhibition of P-gp and MMP-9 expression, is the important mechanisms for treating cerebral vascular diseases.
    CFN99527 Pseudolaric Acid B

    Pseudolaric Acid B has dual antiangiogenic, anti-fungal, anti-fertility, anti-inflammatory, immunomodulatory and pro-apoptosis effects. Pseudolaric Acid B reversed the multidrug resistance of gastric neoplasm to chemotherapy drugs by downregulating the Cox-2/PKC-α/P-gp/mdr1 signaling pathway, it suppressed T lymphocyte activation through inhibition of NF-κB and p38 signaling pathways.
    CFN99491 Hispidulin

    Hispidulin has anti-oxidative, anti-inflammatory, anti-cancer, antiepileptic, neuroprotective, anti-osteoporotic and bone resorption attenuating effects, it targets the VEGF receptor 2-mediated PI3K/Akt/mTOR signaling pathway in endothelial cells, leading to the suppression of pancreatic tumor growth and angiogenesis. Hispidulin can ameliorate high glucose-mediated endothelial dysfunction via inhibiting PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling, it has potential application in the prevention and treatment of diabetic vascular complications. Hispidulin can inhibit platelet aggregation by elevating cAMP levels by a mechanism different from that of theophylline or PGE1.
    CFN99575 Licochalcone A

    Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, antileishmanial, anticancer, anti-inflammatory, antibacterial and antiviral activities. It could be a promising strategy in treating osteoporotic weight-bearing bones fractures with defects, and be a useful compound for the development of antibacterial agents for the preservation of foods containing high concentrations of salts and proteases, in which cationic peptides might be less effective.
    CFN99580 Liensinine

    Liensinine is a human ether-a-go-go-related gene (hERG) inhibitor and a novel autophagy/mitophagy inhibitor, which can antagonize the ventricular arrhythmias. It exerts remarkable effect against thrombosis and possesses strong effect against platelet aggregation and coagulation.
    CFN99586 Mulberroside A

    Mulberroside A, the major active anti-tyrosinase compound in the root bark extract of Morus alba L. (Moraceae), is widely employed as an active ingredient in whitening cosmetics. Mulberroside A has neuroprotective, analgesic, anti-inflammatory, antiapoptotic, uricosuric, nephroprotective, hypoglycemic, and antidiabetic effects.It also can protect mice against ethanol-induced hepatic damage.
    CFN99705 Forsythoside A

    Forsythoside A possesses strong antibacterial, antiinflammatory, antioxidant and antiviral effects. it has the potential to prevent IBV infection in vitro, it can promote the expression of IFN-α and Mx1 significantly.Forsythoside A has inductive effects on the activities of CYP1A2 and CYP2C11, without affecting CYP2D1 and CYP3A1/2 activities.
    CFN99734 Biochanin A

    Biochanin A, an O-methylated natural isoflavonoid classified as phytoestrogen, is a naturally occurring fatty acid amide hydrolase (FAAH) inhibitor, which inhibits FAAH with IC50s of 1.8, 1.4 and 2.4 μM for mouse, rat, and human FAAH, respectively. Biochanin A has hypoglycemic, antilipemic,anti-tumorigenesis, anti-oxidation, and anti-inflammatory properties, it also has neuroprotective effects in cerebral ischemia/reperfusion by inhibiting inflammatory response and the inactivation of p38 signaling pathway. Biochanin A could inhibit Methicillin-resistant Staphylococcus aureus efflux system through reducing pathogen' s expression of nor A and norA protein.