Pyromeconic acid | CAS:496-63-9 | Manufacturer ChemFaces

Pyromeconic acid

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $7.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Pyromeconic acid Description

Source:	The herbs of Erigeron annuus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

J Med Chem. 2016 Jul 14;59(13):6444-54.

Fragment-Based Identification of Influenza Endonuclease Inhibitors.[Pubmed: 27291165 ]

The influenza virus is responsible for millions of cases of severe illness annually. Yearly variance in the effectiveness of vaccination, coupled with emerging drug resistance, necessitates the development of new drugs to treat influenza infections. One attractive target is the RNA-dependent RNA polymerase PA subunit.
METHODS AND RESULTS:
Herein we report the development of inhibitors of influenza PA endonuclease derived from lead compounds identified from a metal-binding pharmacophore (MBP) library screen. Pyromeconic acid and derivatives thereof were found to be potent inhibitors of endonuclease. Guided by modeling and previously reported structural data, several sublibraries of molecules were elaborated from the MBP hits. Structure-activity relationships were established, and more potent molecules were designed and synthesized using fragment growth and fragment merging strategies.
CONCLUSIONS:
This approach ultimately resulted in the development of a lead compound with an IC50 value of 14 nM, which displayed an EC50 value of 2.1 μM against H1N1 influenza virus in MDCK cells.

Structure Identification:

Biosci Biotechnol Biochem. 1995 May;59(5):886-90.

Pyromeconic acid and its glucosidic derivatives from leaves of Erigeron annuus, and the siderophile activity of pyromeconic acid.[Pubmed: 7787303]

3'-O-Caffeylerigeroside (Pyromeconic acid 3-O-beta-D-glucoside 3'-O-caffeyl ester) was obtained from the leaves of Erigeron annuus as a new Pyromeconic acid derivative, and its structure was elucidated. Together with the gamma-pyrone derivative, Pyromeconic acid (3-hydroxy-4H-pyran-4-one) and its beta-glucoside (erigeroside) were also isolated from the aerial parts of E. annuus. The siderophile activity of Pyromeconic acid was also studied.

Product Name	Pyromeconic acid
Price:	$30 / 20mg
CAS No.:	496-63-9
Catalog No.:	CFN96870
Molecular Formula:	C₅H₄O₃
Molecular Weight:	112.08 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Erigeron annuus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Phenols Compound Library Antifection Inhibitor Library

Description:	Pyromeconic acid and derivatives thereof are potent inhibitors of endonuclease, it shows siderophile activity.
Targets:	Antifection

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	8.9222 mL	44.611 mL	89.222 mL	178.444 mL	223.055 mL
5 mM	1.7844 mL	8.9222 mL	17.8444 mL	35.6888 mL	44.611 mL
10 mM	0.8922 mL	4.4611 mL	8.9222 mL	17.8444 mL	22.3055 mL
50 mM	0.1784 mL	0.8922 mL	1.7844 mL	3.5689 mL	4.4611 mL
100 mM	0.0892 mL	0.4461 mL	0.8922 mL	1.7844 mL	2.2305 mL

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CFN92369	5,7-Dihydroxychromone 7-rutinoside	52538-46-2	486.4	C₂₁H₂₆O₁₃
CFN89191	3,5,7-Trihydroxychromone	31721-95-6	194.14	C₉H₆O₅
CFN92552	Eriosematin A	175448-02-9	246.3	C₁₄H₁₄O₄
CFN92835	Eriosemation	162616-72-0	314.4	C₁₉H₂₂O₄
CFN97949	Maltol	118-71-8	126.1	C₆H₆O₃
CFN95641	5-Hydroxymaltol 3-O-beta-D-glucoside	N/A	304.3	C₁₂H₁₆O₉
CFN94478	Kojic acid	501-30-4	142.11	C₆H₆O₄
CFN94111	Chelidonic acid	99-32-1	184.10	C₇H₄O₆
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