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  • Bioactive Products
    Anti-Atherosclerotic Compound Library
    A unique collection of 50 Anti-Atherosclerotic natural compounds for Anti-Atherosclerotic research
    Catalog No: Bb133 Anti-Atherosclerotic Compound Library
    Screening Details
    Size: 1mg/well * 50 Compounds
    2mg/well * 50 Compounds
    Catalog No. Information
    CFN99024 Piceatannol

    1. Piceatannol has antitumor activity.
    2. Piceatannol has the potential to control obesity.
    3. Piceatannol has antioxidant, and anti-inflammatory activities.
    4. Piceatannol inhibits effector T cell functions by suppressing TcR signaling.
    CFN99106 Glycitein

    1. Gycitein has weak estrogenic activity.
    2. Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression.
    3. Glycitein, daidzein and glenistein, with their inhibitory effects on natural and PDGF-BB-induced SMC proliferation, may be useful in attenuating such proliferation, a basic mechanism involved in atherosclerotic vascular change, thereby preventing atherosclerotic cardiovascular diseases.
    4. Glycitein has antioxidant effects, may suppress Abeta toxicity through combined antioxidative activity and inhibition of Abeta deposition, thus may have therapeutic potential for prevention of Abeta associated neurodegenerative disorders.
    5. Glycitein has inhibitory effects on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase.
    6. Glycitein, the most potent activator of ERK1/2, decreases RWPE-1 cell proliferation by 40% ; it induces ERK1/2 activation was dependent, in part, on tyrosine kinase activity associated with vascular endothelial growth factor receptor (VEGFR).
    CFN99434 Tormentic acid

    1. Tormentic acid has anti-allodynic action, can inhibit markedly the neuropathic allodynia induced by partial ligation of the sciatic nerve.
    2. Tormentic acid has anti-inflammatory activity, it potently inhibits the production of nitric oxide (NO) in RAW 264.7 cells, also suppresses the LPS-stimulated degradation and phosphorylation of inhibitor of kappa B-α (IκB-α), suggests that the anti-inflammatory activity of TA is associated with the down-regulation of iNOS, COX-2, and TNF-α through the negative regulation of the NF-κB pathway in RAW 264.7 cells.
    3. Tormentic acid has anticancer, anti-atherogenic properties and minimal toxicity in vivo, it also can reduce vascular smooth muscle cell proliferation and survival.
    4. Tormentic acid has protective effect against lipopolysaccharide/D-galactosamine induced fulminant hepatic failure in mice.
    CFN99458 Ergosterol peroxide glucoside

    1. Ergosterol peroxide exhibits inhibitory effects on human breast adenocarcinoma MCF-7 cells, it inhibits the growth of MCF-7 cells by inducing cell apoptosis.
    2. Ergosterol peroxide exhibits hACAT-1 and Lp-PLA2 inhibitory effects, with inhibitory values of 51.6 +/- 0.9 and 51.7 +/- 1.2%, at a treatment concentration of 0.23 mM; suggests that it could as an anti-atherosclerosis agent.
    3. Ergosterol peroxide shows very strong anticomplementary activity on the classical pathway, the IC(50) values being 5.0 muM.
    4. Ergosterol peroxide can suppress inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells, it appears to suppress cell growth and STAT1 mediated inflammatory responses by altering the redox state in HT29 cells.
    5. Ergosterol peroxide has anti-melanogenic activity.
    6. Ergosterol peroxide has amoebicidal activity (IC50 =4.23nM), it produces a strong cytotoxic effect against amoebic growth.
    7. Ergosterol peroxide has osteoclastogenesis inhibitory effect, it shows an inhibitory effect in a dose-dependent manner and an inhibition rate of up to 62% with low cytotoxicity, even at a concentration as low as 1.0 microg/mL.
    8. Ergosterol peroxide has antibacterial activity against Mycobacterium tuberculosis and has antiviral action.
    9. Ergosterol peroxide has anti-oxdiant activity.
    CFN99539 Danshensu

    1. Danshensu has antioxidant activity, can enhance HO-1 expression to suppress 6-OHDA-induced oxidative damage via PI3K/Akt/Nrf2 signaling pathways.
    2. Danshensu has neuroprotective activity, can reduce 6-OHDA-induced dopaminergic neuronal loss in zebrafish.
    3. Danshensu has anxiolytic-like properties, in part, through dopaminergic neurotransmitter signaling.
    4. Danshensu has cardioprotective effect, can treat cardiovascular diseases.
    5. Chronic treatment with danshensu can prevent/attenuate the formation of atherosclerosis, the potential mechanisms include inhibited expression of representative proinflammatory cytokines and adhesion molecules in arterial endothelia, and changes in homocysteine and circulating molecules that control vascular contraction/relaxation via endothelial cells (eg, endothelin and NO).