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  • Bioactive Products
    Antiangiogenic Compound Library
    A unique collection of 69 Antiangiogenic natural compound library for Antiangiogenic screening
    Catalog No: B94 Antiangiogenic Compound Library
    Screening Details
    Size: 1mg/well * 69 Compounds
    2mg/well * 69 Compounds
    Catalog No. Information
    CFN99011 Artemisinin

    1. Artemisinin has antimalarial activity.
    2. Artemisinin inhibits tumor necrosis factor-α-induced vascular smooth muscle cell proliferation.
    3. Artemisinin is active against different bacteria and certain fungal species.
    CFN99013 4-Hydroxybenzaldehyde

    1. 4-Hydroxybenzaldehyde shows an inhibitory effect on the GABA transaminase to contribute to an antiepileptic and anticonvulsive activity, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant.
    CFN99130 Theaflavin 3,3'-di-O-gallate

    1. Theaflavin-3,3'-digallate(TF3), an inducer of oxidative stress and apoptosis, shows a concentration and time dependent inhibition of growth, with the tumor cells more sensitive than the fibroblasts.
    2. Theaflavin-3,3'-digallate may exert its anti-inflammatory and cancer chemopreventive actions by suppressing the activation of NFκB through inhibition of IKK activity.
    3. Theaflavin-3,3'-digallate induces epidermal growth factor receptor (EGFR) endocytosis and degradation, it stimulates EGFR ubiquitination and tyrosine kinase activation; indicates that TF-3 mayt exert chemopreventive effects through the downregulation of the EGFR.
    4. Theaflavin-3,3'-digallate and lactic acid combinations can reduce Herpes Simplex Virus(HSV) infectivity.
    5. Theaflavin-3,3'-digallate has anticancer properties, TF3 reduces tumor angiogenesis by downregulating HIF-1αand VEGF; suggests that TF3 might serve as a potential anti-angiogenic agent for cancer treatment.
    CFN99142 Genipin

    1. Genipin is a novel chemical activator of EBV lytic cycle.
    2. Genipin is used for choleretic action for liver diseases control.
    3. Genipin inhibits MMP-1 and MMP-3 release from TNF-a-stimulated human periodontal ligament cells.
    4. Genipin is an excellent natural cross-linker for proteins, collagen, gelatin, and chitosan cross-linking, can be used as a regulating agent for drug delivery, as the raw material for gardenia blue pigment preparation.
    5. Genipin blocks the action of the enzyme uncoupling protein 2. Uncoupling protein-2 (UCP2), is a UCP2 inhibitor.the chemical inhibition of UCP2 with genipin sensitizes multidrug-resistant cancer cells to cytotoxic agents.
    6. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced βcell dysfunction in isolated pancreatic islets in a -dependent manner,it represents that comprise a starting point for the of therapies aimed at treating beta cell dysfunction.
    7. Genipin cross-linked electrospun gelatin mats loaded with vascular endothelial growth factor (VEGF) could be part of a useful strategy to stimulate and induce angiogenesis in tissue engineered applications.
    8. Genipin shows an antithrombotic effect in vivo due to the suppression of platelet aggregation, phospholipase A(2) (PLA(2)) inhibition by geniposide is one possible anti-platelet mechanism.
    9. Genipin induces cyclooxygenase-2 expression via NADPH oxidase, MAPKs, AP-1, and NF-κB in RAW 264.7 cells.
    CFN99179 Rosavin

    1. Rosavin and rhodiola rosea extracts decrease neovascular reaction on cutaneous angiogenesis induced in mice after grafting of syngeneic tumor cells.
    2. Rosavin, extracted from Rhodiola rosea L, has anti-fatigue effects.