1. Epifriedelanol can suppress adriamycin-induced cellular senescence as well as replicative senescence in human fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs), suggests that epifriedelanol can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases.
2. Epifriedelanol exhibits significant inhibition of NF-kappa B, it may be used to treat asthma.
3. Epifriedelanol has antitumor activity.
1. Shikonin is a natural red naphthoquinone pigment; at present, a purified shikonin preparation is widely used in Japan for the production of medicinals, cosmetics, and some food products; in Russia, shikonin enters into the antiinflammatory ointment and cream compositions used for the treatment of burns; shikonin also possesses a broad spectrum of antimicrobial activity.
2. Shikonin exhibits its anti-tumor activity through inhibiting cell growth and promoting apoptosis by negatively regulating PI3K/Akt signaling ,targeting mitochondrial-related signaling pathway.
3. Shikonin can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway.
4. Shikonin can suppress inflammatory reactions, the inhibition of Syk-dependent phosphorylation events might underlie the blocked histamine release from human basophils, thus contributing to the anti-inflammatory effects of shikonin.
1. A composition containing an effective amount of D-xylose, an ester thereof or an oligosaccharide containing D-xylose, in a combination with a cosmetically or pharmaceutically acceptable excipient.
1. Cinnamyl acetate is used as flavor and fragrance ingredient in food and cosmetic industries.
1. Falcarindiol has antimutagenic activity, can suppress the mutagenicity of furylfuramide and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1).
2. Falcarindiol inhibits nitric oxide-mediated neuronal death in lipopolysaccharide-treated organotypic hippocampal cultures, it has neuroprotective activity.
3. Falcarindiol has inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth.
4. Falcarindiol has protective effects against CCl(4) toxicity, in part, the effects might be explained by anti-lipid peroxidation activity associated with the induction of the GSTs including GSTA4.
5. Falcarindiol has antifungal activity.
6. Falcarindiol can strongly inhibit the growth of Micrococcus luteus and Bacillus cereus, with a minimum inhibitory concentration (MIC) value of 50 microg ml(-1), and it shows cytotoxicity against IEC-6 cells,suggests that it could be potentially used in food manufactures and cosmetology as preservative agents and biopesticides, or in medicine as new antibiotics.
7. Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis.