Homovanillic acid is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain. Abnormalities in white matter were associated with low CSF Homovanillic acid.
Herbacetin, a novel Met inhibitor with a potential utility in cancer therapeutics, suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation. Herbacetin exerts an anti-inflammatory effect through suppression of LPS-induced JNK and NF-κB signaling pathways and diminished production of proinflammatory cytokines and mediators. Herbacetin also has a strong ability to scavenge free radical and inhibit oxidative protein damage.
4-Dimethylaminocinnamaldehyde is a photometric reagent for primary aromatic amines. The 4-(dimethylamino)cinnamaldehyde assay is currently used to quantify proanthocyanidin (PAC) content in cranberry products.
1. 3,4-Dihydroxyphenylglycol has antioxidant activity.
2. Plasma 3,4-dihydroxyphenylglycol and 3-methoxy-4-hydroxyphenylglycol are insensitive indicators of alpha 2-adrenoceptor mediated regulation of norepinephrine release in healthy human volunteers.
3. 3,4-Dihydroxyphenylglycol and hydroxytyrosyl acetate show a strong reactive oxygen species (ROS)-scavenging activity, reducing significantly nitrite levels with a significant decrease on iNOS expression, their phenolic derivatives could play an important role in the anti-inflammatory effect of extra virgin olive oil.
Tricine can clearly visualize tumors, may as melanoma imaging agents. Using the combination of tricine and a phosphine ligand, HYNIC-derivatized peptides or other small molecules can be labeled with 99mTc in high specific activity and with high stability for potential use as radiopharmaceuticals.