1. Glycyrrhetinic acid is a potent inducer of mitochondrial permeability transition and can trigger the pro-apoptotic pathway.
2. Glycyrrhetinic acid and some of its derivatives have anti-inflammatory activities.
3. Glycyrrhizic acid has a low but definite affinity for mineralocorticoid receptors and thus appears to have a direct mineralocorticoid action.
4. Glycyrrhetinic acid has antileukaemic activity.
5. Glycyrrhetinic acid is an AChE activator.
6. Glycyrrhetinic acid inhibits cell proliferation in NSCLC cells, and inhibits cell growth and induces apoptosis in ovarian cancer a2780 cells.
1. The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo.
2. 11 alpha- and 11 beta-Hydroxyprogesterone are potently hypertensinogenic in the rat and that this activity depends on an intact adrenal and at least in part on the activation of mineralocorticoid receptors.
3. 11beta-Hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.