1. Theobromine may have therapeutic potential for diabetic nephropathy, by reducing kidney ECM accumulation in diabetic.
2. Theobromine independently increased serum HDL-cholesterol concentrations by 0.16 mmol/L.
3. Theobromine at normal intake ranges may contribute to the positive effects of chocolate, but at higher intakes, effects become negative.
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome,liver and kidney functions by reduction of pro-inflammatory cytokines and LPS.
2. Atractylenolide-I significantly sensitizes the response of MyD88(+) EOC cells to paclitaxel by blocking MD-2-mediated TLR4/MyD88 signaling.
1. Benzoylecgonine causes oxidative stress.
2. Benzoylecgonine and oxytocin increase myometrial contractility, while atosiban and ritodrine induce myometrial relaxation.
3. Benzoylecgonine, validated methodologies from matrices other than blood that can be obtained in the autopsy room would be useful to the forensic toxicologist in the evaluation of a specific forensic case.
1. Theaflavin-3-gallate and theaflavin-3'-gallate, act as prooxidants and induce oxidative stress, with carcinoma cells more sensitive than normal fibroblasts.
1. Alpha-pinene inhibits early root growth and causes oxidative damage in root tissue through enhanced generation of ROS, as indicated by increased lipid peroxidation, disruption of membrane integrity and elevated antioxidant enzyme levels.
2. Alpha-pinene inhibits the nuclear translocation of NF-kappa B induced by LPS in THP-1 cells, and this effect is partly due to the upregulation of I kappa B alpha expression.