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    Benzoylecgonine
    Benzoylecgonine
    Information
    CAS No. 519-09-5 Price
    Catalog No.CFN00191Purity>=98%
    Molecular Weight289.33Type of CompoundAlkaloids
    FormulaC16H19NO4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Benzoylecgonine causes oxidative stress.
    2. Benzoylecgonine and oxytocin increase myometrial contractility, while atosiban and ritodrine induce myometrial relaxation.
    3. Benzoylecgonine, validated methodologies from matrices other than blood that can be obtained in the autopsy room would be useful to the forensic toxicologist in the evaluation of a specific forensic case.
    Benzoylecgonine Description
    Source: The herbs of Erythroxylum coca
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4563 mL 17.2813 mL 34.5626 mL 69.1252 mL 86.4065 mL
    5 mM 0.6913 mL 3.4563 mL 6.9125 mL 13.825 mL 17.2813 mL
    10 mM 0.3456 mL 1.7281 mL 3.4563 mL 6.9125 mL 8.6407 mL
    50 mM 0.0691 mL 0.3456 mL 0.6913 mL 1.3825 mL 1.7281 mL
    100 mM 0.0346 mL 0.1728 mL 0.3456 mL 0.6913 mL 0.8641 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Benzoylecgonine References Information
    Citation [1]

    J Forensic Leg Med. 2014 Mar;23:37-43.

    Determination of cocaine and its major metabolite benzoylecgonine in several matrices obtained from deceased individuals with presumed drug consumption prior to death.[Pubmed: 24661704]
    In particular, when femoral blood is unavailable for analysis for the presence of systemic exposure to cocaine and its principal metabolite, Benzoylecgonine, validated methodologies from matrices other than blood that can be obtained in the autopsy room would be useful to the forensic toxicologist in the evaluation of a specific forensic case. To address this issue, we implemented and compared in our study the systematic evaluation of extraction, chromatographic separation, and quantification of cocaine and Benzoylecgonine in different biological matrices (right and left cardiac blood, femoral arterial and venous blood, urine, vitreous humor, cerebrospinal fluid, brain accumbens nucleus, brain ventral tegmental area, and liver). The methods were applied to evaluate a thanatological case using all the study matrices, showing unequal postmortem distribution of cocaine and Benzoylecgonine throughout the different matrices tested.
    Citation [2]

    Am J Forensic Med Pathol. 2015 Jun;36(2):84-7.

    The effect of chronic renal failure on the benzoylecgonine blood level: a case report.[Pubmed: 25881815]
    This report describes a case of a man who died in jail, after less than 48 hours of being incarcerated, wherein postmortem toxicology testing revealed a blood Benzoylecgonine level of 0.25 mg/L with no cocaine detected, suggesting possible recent cocaine use in jail. Autopsy and investigation revealed severe underlying cardiovascular disease and dialysis-dependent CRF, thus accounting for the elevated Benzoylecgonine levels and allaying concerns that the man obtained and used cocaine in jail.
    Citation [3]

    Analyst. 2015 May 15.

    Rapid detection of cocaine, benzoylecgonine and methylecgonine in fingerprints using surface mass spectrometry.[Pubmed: 25977942]
    Gas chromatography mass spectrometry (GC-MS) was used to test the oral fluid of patients for the presence of cocaine and Benzoylecgonine. The corresponding fingerprints were analysed using Desorption Electrospray Ionization (DESI) which operates under ambient conditions and Ion Mobility Tandem Mass Spectrometry Matrix Assisted Laser Desorption Ionization (MALDI-IMS-MS/MS) and Secondary Ion Mass Spectrometry (SIMS). The detection of cocaine, Benzoylecgonine (BZE) and methylecgonine (EME) in latent fingerprints using both DESI and MALDI showed good correlation with oral fluid testing.
    Citation [4]

    Drug Test Anal. 2013 Aug;5(8):646-56.

    A redox proteomic investigation of oxidative stress caused by benzoylecgonine in the freshwater bivalve Dreissena polymorpha.[Pubmed: 22991338]
    One of the most abundant drugs found in rivers and wastewaters is Benzoylecgonine (BE), the main metabolite of cocaine. We applied a redox proteomics approach to evaluate changes in the proteome of Dreissena polymorpha exposed to two different concentrations of Benzoylecgonine (0.5 and 1 µg/l).This yielded de novo protein sequences suitable for database searching. These preliminary results and protein identifications obtained suggest that Benzoylecgonine causes oxidative stress. Oxidative modifications were detected in differing classes of proteins such as those of the cytoskeleton, energetic metabolism and stress response.
    Citation [5]

    Clin Exp Obstet Gynecol. 2012;39(1):36-42.

    The effects of benzoylecgonine, oxytocin, ritodrine and atosiban on the contractility of myometrium. An experimental study.[Pubmed: 22675953]
    PURPOSE: To investigate the response of pregnant and non pregnant rat myometrium to Benzoylecgonine, a cocaine metabolite, and oxytocin and to investigate the efficiency of ritodrine and atosiban to overcome the effects of Benzoylecgonine and oxytocin. METHODS: Isolation of rat myometrial tissue and recording of contractile activity with isotonic muscle transducer. RESULTS: Benzoylecgonine and oxytocin increase myometrial contractility, while atosiban and ritodrine induce myometrial relaxation. Atosiban was able to revoke the action of oxytocin but not the action of Benzoylecgonine. Ritodrine was able to induce muscle relaxation in both oxytocin and Benzoylecgonine administration.