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    1-Hydroxyrutaecarpine
    Information
    CAS No. 53600-24-1 Price
    Catalog No.CFN98895Purity>=98%
    Molecular Weight303.3 Type of CompoundAlkaloids
    FormulaC18H13N3O2Physical DescriptionYellow powder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. 1-Hydroxyrutaecarpine exhibits cytotoxicities (ED50 values < 4 microg/mL) against P-388 or HT-29 cell lines in vitro.
    2. 1-Hydroxyrutaecarpine exhibits antiplatelet activity induced by AA and shows an IC50 value of ca.1-2 micrograms/ml.
    3. 1-Hydroxyrutaecarpine displays moderate inhibitory activity on those enzymes(Cathepsins B, L and K) at the concentration of 125 ug/ml.
    1-Hydroxyrutaecarpine Description
    Source: The fruits of Evodia rutaecarpa (Juss.) Benth.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2971 mL 16.4853 mL 32.9707 mL 65.9413 mL 82.4266 mL
    5 mM 0.6594 mL 3.2971 mL 6.5941 mL 13.1883 mL 16.4853 mL
    10 mM 0.3297 mL 1.6485 mL 3.2971 mL 6.5941 mL 8.2427 mL
    50 mM 0.0659 mL 0.3297 mL 0.6594 mL 1.3188 mL 1.6485 mL
    100 mM 0.033 mL 0.1649 mL 0.3297 mL 0.6594 mL 0.8243 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    1-Hydroxyrutaecarpine References Information
    Citation [1]

    Planta Med. 2005 May;71(5):470-5.

    New indolopyridoquinazoline, benzo[c]phenanthridines and cytotoxic constituents from Zanthoxylum integrifoliolum.[Pubmed: 15931588]
    Three new alkaloids, 7,8-dehydro-1-methoxyrutaecarpine, isodecarine, and 8-demethyloxychelerythrine, together with sixteen known compounds, norchelerythrine, oxychelerythrine, decarine, dihydrocherythrinylacetaldehyde, 6-acetonyldihydrochelerythrine, rutaecarpine, 1-Hydroxyrutaecarpine, gamma-fagarine, skimmianine, (-)-matairesinol, (-)-isoarctigenin, (+)-epipinoresinol, d-sesamin, lupeol, canthin-6-one, and arnottianamide have been isolated from the root bark of Zanthoxylum integrifoliolum. The structures of these new compounds were determined through spectral analyses. Among the isolates, 7,8-dehydro-1-methoxyrutaecarpine, norchelerythrine, oxychelerythrine, dihydrocherythrinylacetaldehyde, 6-acetonyldihydrochelerythrine, 1-Hydroxyrutaecarpine, gamma-fagarine, skimmianine, (-)-matairesinol, and canthin-6-one exhibited cytotoxicities (ED50 values < 4 microg/mL) against P-388 or HT-29 cell lines in vitro.
    Citation [2]

    Planta Med. 1996 Apr;62(2):175-6.

    Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum.[Pubmed: 8657756]
    Bioassay-guided fractionation led to the isolation of three indolopyridoquinazoline alkaloids, 1-Hydroxyrutaecarpine, rutaecarpine, and 1-methoxyrutaecarpine as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylum integrifoliolum (Rutaceae). 1-Hydroxyrutaecarpine exhibited antiplatelet activity induced by AA and showed an IC50 value of ca. 1-2 micrograms/ml.
    Citation [3]

    Planta Medica, 2012 , 78 (11) :1094-1094

    The alkaloid 1-hydroxyrutaecarpine inhibits cathepsin activity[Reference: WebLink]
    Cathepsins B, L and K are cysteine proteases involved in various physiological and pathological processes. CatB and L are involved in tumoral processes while catK in cases of bone resorption. In a search for cathepsin inhibitors we have isolated from Metrodorea stipullaris, a number of compounds, among them the alkaloid 1-Hydroxyrutaecarpine which displayed moderate inhibitory activity on those enzymes. The alkaloid showed inhibition of 79% on cathepsin B, 100% on cathepsin L and 87.5% on cathepsin K, at the concentration of 125μg/ml for the three cathepsins. IC50 experiments were run and the values obtained are described in the table below.