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    2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one
    2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one
    Information
    CAS No. 1809980-25-3 Price $318 / 10mg
    Catalog No.CFN95197Purity>=98%
    Molecular Weight320.4Type of CompoundSesquiterpenoids
    FormulaC18H24O5Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Description: Reference standards.
    2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one Description
    Source: The herbs of Curcuma phaeocaulis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1211 mL 15.6055 mL 31.211 mL 62.422 mL 78.0275 mL
    5 mM 0.6242 mL 3.1211 mL 6.2422 mL 12.4844 mL 15.6055 mL
    10 mM 0.3121 mL 1.5605 mL 3.1211 mL 6.2422 mL 7.8027 mL
    50 mM 0.0624 mL 0.3121 mL 0.6242 mL 1.2484 mL 1.5605 mL
    100 mM 0.0312 mL 0.1561 mL 0.3121 mL 0.6242 mL 0.7803 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Chinese Journal of Medicinal Chemistry, 2015.
    Isolation and identification of terpenoids from Myrrh.[Reference: WebLink]

    METHODS AND RESULTS:
    The chemical constituents from the CHCl3 extract of Commiphora opobalsamum were isolated and purified by various kind of column chromatography on silica gel,Sephadex LH-20 and ODS,and their structures were elucidated by the physico-chemical characters and the spectroscopic analysis. Twelve compounds were obtained and identified as proximadiol( 1),orientalol E( 2),alismol( 3),guaianediol( 4),( 1( 10) E,2R*,4R*,5S*)-2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one( 5),( 1( 10) E,2R*,4R*)-2- methoxy-8,12-epoxygermacra-1( 10),7,11-trien-6-one( 6),myrrhone( 7),dihydropyrocurzerenone( 8),cycloartane-1α,2α,3β,25-tetrol( 9),cycloartan-24-ene-1α,2α,3β-triol( 10),cycloartan-24-ene-1α,3β-diol( 11),and 29-norlanost-8,24-dien-1α,2α,3β-triol( 12),respectively. Compounds 1- 3 were isolated from Commiphora for the first time. All the isolated compounds were evaluated for their cytotoxicity against the PC-3hunman prostate tumor cell line.
    CONCLUSIONS:
    Only compounds 10 and 12 exhibited weak cytoxicity with IC50 values of37. 4 μmol·L~(-1),26. 2 μmol·L~(-1),respectively.