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    3,4-Dimethoxycinnamic acid
    Information
    CAS No. 2316-26-9 Price $30 / 20mg
    Catalog No.CFN98194Purity>=98%
    Molecular Weight208.21Type of CompoundPhenylpropanoids
    FormulaC11H12O4Physical DescriptionWhite powder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 3,4-Dimethoxycinnamic acid is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.
    In vitro:
    Mol Nutr Food Res. 2012 Sep;56(9):1413-23.
    Absorption of dimethoxycinnamic acid derivatives in vitro and pharmacokinetic profile in human plasma following coffee consumption.[Pubmed: 22865606 ]
    This study reports the 24 h human plasma pharmacokinetics of 3,4-Dimethoxycinnamic acid (dimethoxycinnamic acid) after consumption of coffee, and the membrane transport characteristics of certain dimethoxycinnamic acid derivatives, as present in coffee.
    METHODS AND RESULTS:
    For the first time, we show that 3,4-Dimethoxycinnamic acid appears in plasma as the free aglycone. The time to reach the C(max) value of approximately 0.5 μM was rapid, T(max) = 30 min, and showed an additional peak at 2-4 h for several subjects. In contrast, smaller amounts of dimethoxy-3,4-Dimethoxycinnamic acid (C(max) ∼ 0.1 μM) peaked between 8 and 12 h after coffee intake. In the cell model, 3,4-Dimethoxycinnamic acid was preferentially transported in the free form by passive diffusion, and a small amount of dimethoxycinnamoylquinic acid hydrolysis was observed.
    CONCLUSIONS:
    These findings show that 3,4-Dimethoxycinnamic acid, previously identified in plasma after coffee consumption, was rapidly absorbed in the free form most likely by passive diffusion in the upper gastrointestinal tract.
    3,4-Dimethoxycinnamic acid Description
    Source: The leaves of Phyllostachys heterocycla
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.8028 mL 24.0142 mL 48.0284 mL 96.0569 mL 120.0711 mL
    5 mM 0.9606 mL 4.8028 mL 9.6057 mL 19.2114 mL 24.0142 mL
    10 mM 0.4803 mL 2.4014 mL 4.8028 mL 9.6057 mL 12.0071 mL
    50 mM 0.0961 mL 0.4803 mL 0.9606 mL 1.9211 mL 2.4014 mL
    100 mM 0.048 mL 0.2401 mL 0.4803 mL 0.9606 mL 1.2007 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.